INT147809

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Context Info
Confidence 0.71
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.69
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SLC6A4) endosome (SLC6A4) plasma membrane (SLC6A4)
Anatomy Link Frequency
platelet 1
intestine 1
SLC6A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 34 99.18 Very High Very High Very High
Catechol-O-methyltransferase 9 98.64 Very High Very High Very High
Inflammation 2 98.36 Very High Very High Very High
tolerance 10 91.60 High High
Serotonin 43 88.64 High High
metalloproteinase 2 86.96 High High
depression 15 69.76 Quite High
Neurotransmitter 7 62.56 Quite High
antagonist 4 60.08 Quite High
Central nervous system 4 49.00 Quite Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 65 99.16 Very High Very High Very High
INFLAMMATION 2 98.36 Very High Very High Very High
Stress 22 95.44 Very High Very High Very High
Eczema 18 94.40 High High
Enteropathy 1 92.40 High High
Fatigue 13 90.00 High High
Chronic Fatigue Syndrome 40 86.36 High High
Depression 16 69.76 Quite High
Disease Susceptibility 5 54.24 Quite High
Pain 12 42.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Current studies were designed to characterize the function, expression, distribution, and membrane localization of SERT in the native human intestine.
Localization (localization) of SERT in intestine
1) Confidence 0.71 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17991706 Disease Relevance 0.09 Pain Relevance 0.12
The relationship between nicotine and cotinine was r = 0.616, P < 0.001.

5-HTTLPR and family relations in association with smoking

Localization (relations) of 5-HTTLPR associated with nicotine addiction and nicotine
2) Confidence 0.66 Published 2009 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2852756 Disease Relevance 0.51 Pain Relevance 0.23
Consistent with this suggestion was the correlation analysis in the present study: the lower the density and rate of SERT on platelet membranes, the higher the severity of FM symptoms.
Localization (rate) of SERT in platelet
3) Confidence 0.60 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779383 Disease Relevance 0.16 Pain Relevance 0.10
As shown in Table 2[18], there were ten candidate genes including COMT, corticotropin releasing hormone receptor 1 (CRHR1), corticotropin releasing hormone receptor 2 (CRHR2), MAOA, MAOB, NR3C1, POMC, solute carrier family 6 member 4 (SLC6A4), tyrosine hydroxylase (TH), and TPH2 genes.
Localization (releasing) of SLC6A4 associated with catechol-o-methyltransferase
4) Confidence 0.51 Published 2009 Journal J Transl Med Section Body Doc Link PMC2765429 Disease Relevance 0.49 Pain Relevance 0.13
In addition, pharmacological treatment targeting the serotonergic receptors and SERT might be a possible treatment strategy.



Localization (targeting) of SERT
5) Confidence 0.43 Published 2008 Journal Journal of the European Academy of Dermatology and Venereology Section Body Doc Link PMC2229631 Disease Relevance 0.43 Pain Relevance 0.15

General Comments

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