INT147810

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Context Info
Confidence 0.03
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.13
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
bone marrow 1
TP53TG3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 106 97.60 Very High Very High Very High
cytokine 42 81.12 Quite High
Inflammatory response 19 35.00 Quite Low
palliative 1 25.00 Low Low
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 9 99.98 Very High Very High Very High
Apoptosis 24 99.84 Very High Very High Very High
Cancer 178 98.50 Very High Very High Very High
INFLAMMATION 138 97.60 Very High Very High Very High
Adenocarcinoma 6 90.96 High High
Breast Cancer 26 86.72 High High
Infection 16 76.48 Quite High
Hepatitis B Virus Infection 2 76.08 Quite High
Atherosclerosis 27 69.44 Quite High
Cardiovascular Disease 6 67.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
3) Alterations of the p53 gene induced by NO derived radicals promoting clonal expansion of aberrant or mutated cells [92].
Positive_regulation (induced) of p53 gene
1) Confidence 0.03 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1166571 Disease Relevance 1.37 Pain Relevance 0.34
Tumor protein 53-induced nuclear protein 1 (TP53INP1) is a pro-apoptotic stress-induced p53 target gene.
Positive_regulation (induced) of target gene associated with stress, cancer and apoptosis
2) Confidence 0.01 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.96 Pain Relevance 0
Other prognostic and predictive factors have been studied in an effort to explain this phenomenon, some of which are more relevant than others: HER-2/neu gene amplification and protein expression, expression of other members of the epithelial growth factor receptor family, S phase fraction, DNA ploidy, p53 gene mutations, cyclin E, p27 dysregulation, the presence of tumor cells in the circulation or bone marrow, and perineural and lymphovascular space invasion.
Positive_regulation (mutations) of p53 gene in bone marrow associated with cancer
3) Confidence 0.01 Published 2007 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 17993229 Disease Relevance 0.80 Pain Relevance 0

General Comments

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