INT147880

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Context Info
Confidence 0.33
First Reported 2007
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 13.99
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SRGN) extracellular region (SRGN) Golgi apparatus (SRGN)
Anatomy Link Frequency
lens 3
plasma 2
eyes 1
retina 1
superior 1
SRGN (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 173 83.80 Quite High
antagonist 64 81.72 Quite High
Pain 11 81.72 Quite High
diabetic neuropathy 2 79.40 Quite High
Dopamine 80 75.04 Quite High
Inflammation 24 71.56 Quite High
Serotonin 8 58.72 Quite High
depression 16 52.36 Quite High
Onset of action 25 5.00 Very Low Very Low Very Low
Central nervous system 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoglycemia 748 99.68 Very High Very High Very High
Myopia 552 99.56 Very High Very High Very High
Disease 87 99.40 Very High Very High Very High
Cardiovascular Disease 218 99.18 Very High Very High Very High
Diabetes Mellitus 1432 98.98 Very High Very High Very High
Death 19 98.74 Very High Very High Very High
Diabetes Complications 20 98.20 Very High Very High Very High
Hypertension 2 97.00 Very High Very High Very High
Neuropathic Pain 14 96.96 Very High Very High Very High
Hyperglycemia 100 96.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These were used for comparing the changes in the PPG signal components with IBP pressure changes.
Regulation (changes) of PPG
1) Confidence 0.33 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2852789 Disease Relevance 0.13 Pain Relevance 0
Thus, attaining glycemic control, and reducing CVD risk, may be difficult without adequate control of PPG levels.
Neg (without) Regulation (control) of PPG associated with cardiovascular disease
2) Confidence 0.30 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515417 Disease Relevance 1.99 Pain Relevance 0
Effective treatment should target both basal and PPG levels.
Regulation (target) of PPG
3) Confidence 0.26 Published 2008 Journal Osteopath Med Prim Care Section Body Doc Link PMC2276216 Disease Relevance 0.20 Pain Relevance 0
Improvements in PPG control may also have the potential to reduce other diabetes complications, but this has yet to be proven in prospective, randomized controlled trials.
Regulation (control) of PPG associated with diabetes complications
4) Confidence 0.23 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350128 Disease Relevance 0.34 Pain Relevance 0
In patients with type 2 diabetes, several studies have shown that biphasic insulin aspart 70/30 twice daily at breakfast and dinner is more effective in controlling PPG than other insulin regimens.
Regulation (controlling) of PPG associated with diabetes mellitus
5) Confidence 0.23 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350128 Disease Relevance 0.35 Pain Relevance 0
Effective treatment, therefore, should encompass the means to control both basal and PPG excursions.
Regulation (control) of PPG
6) Confidence 0.23 Published 2008 Journal Osteopath Med Prim Care Section Body Doc Link PMC2276216 Disease Relevance 1.06 Pain Relevance 0
Sensitivities of the PPG method were found to be 98.0 % for both sides.
Regulation (Sensitivities) of PPG
7) Confidence 0.23 Published 2007 Journal Conf Proc IEEE Eng Med Biol Soc Section Abstract Doc Link 18002429 Disease Relevance 0.59 Pain Relevance 0.16
With regard to the values of the PPG components, transmission current during systole (ITsys) and transmission current during diastole (ITdia) were detected from the foot and peak of the DC signal, respectively.
Regulation (values) of PPG in foot
8) Confidence 0.20 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2852789 Disease Relevance 0.12 Pain Relevance 0
In this study we did not find significant effects of the experimental manipulations in one eye on ZENK or PPG transcript levels in the contralateral eyes of treated animals at any point within the time-course investigated.
Neg (not) Regulation (effects) of PPG in eyes
9) Confidence 0.17 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2855734 Disease Relevance 0.52 Pain Relevance 0.28
In general, changes in both ZENK and PPG transcript levels correlated well with the refractive changes observed during negative-lens compensation.
Regulation (changes) of PPG in lens
10) Confidence 0.17 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2855734 Disease Relevance 0.51 Pain Relevance 0.03
PPG RNA transcript levels in the retina were not significantly affected by 1h of form-deprivation (t-test; p=0.61; Figure 4).
Neg (not) Regulation (affected) of PPG RNA transcript in retina
11) Confidence 0.17 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2855734 Disease Relevance 0.27 Pain Relevance 0
HbA1c reductions can be of a greater magnitude with premixed insulin analogs than with basal analogs (Table 2), largely because PPG can be better controlled with premixed human insulins than with basal insulin alone.
Regulation (controlled) of PPG
12) Confidence 0.13 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515417 Disease Relevance 0.49 Pain Relevance 0
Using this strategy, PPG excursions may be controlled by a combination of OADs and the recovered beta-cell secretory capacity that basal insulin supplementation may afford.
Spec (may) Regulation (controlled) of PPG
13) Confidence 0.13 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515417 Disease Relevance 0.52 Pain Relevance 0
It follows that in order to achieve HbA1c treatment goals, PPG control must be targeted as well, particularly in more advanced disease.
Regulation (control) of PPG associated with disease
14) Confidence 0.13 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515417 Disease Relevance 0.34 Pain Relevance 0
A single injection of biphasic insulin aspart delivers both insulin coverage for a meal (prandial insulin) and more long-lasting insulin coverage (basal insulin), thus targeting PPG, while also maintaining control of fasting plasma glucose.
Regulation (targeting) of PPG in plasma
15) Confidence 0.12 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350128 Disease Relevance 0.34 Pain Relevance 0
Conventional basal-bolus therapy, consisting of three daily injections of rapid- or short-acting insulin at every meal and one or two additional basal insulin injections, target both PPG and fasting plasma glucose; however they are not always practical as they require multiple daily injections.
Regulation (target) of PPG in plasma
16) Confidence 0.10 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350128 Disease Relevance 0.42 Pain Relevance 0
Thus, compared to biphasic human insulin, biphasic insulin aspart twice daily significantly improved PPG control in patients with type 1 and type 2 diabetes.
Regulation (control) of PPG associated with diabetes mellitus
17) Confidence 0.10 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350128 Disease Relevance 0.79 Pain Relevance 0
Another study involving both type 1 and type 2 diabetics showed that biphasic insulin aspart twice daily significantly improves PPG control while achieving similar HbA1c levels compared to biphasic human insulin twice daily.
Regulation (control) of PPG associated with diabetes mellitus
18) Confidence 0.10 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350128 Disease Relevance 0.73 Pain Relevance 0
As large epidemiologic studies suggest that PPG levels correlate better with adverse cardiovascular outcomes and death, one potential advantage of biphasic insulin aspart is better PPG control.
Regulation (control) of PPG associated with death
19) Confidence 0.10 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350128 Disease Relevance 0.33 Pain Relevance 0
Changes in ZENK transcript expression were followed by a slower but similar change in retinal PPG transcript levels during both FDM and LIM.
Regulation (change) of PPG associated with myopia
20) Confidence 0.08 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2855734 Disease Relevance 0.52 Pain Relevance 0.03

General Comments

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