INT147896

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Context Info
Confidence 0.58
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.01
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gap43)
Anatomy Link Frequency
sensory neurons 2
neurons 1
neurite 1
Gap43 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 6 100.00 Very High Very High Very High
bDMF 213 98.20 Very High Very High Very High
induced neuropathy 2 98.04 Very High Very High Very High
Inflammation 20 96.32 Very High Very High Very High
Kinase C 3 95.40 Very High Very High Very High
Neuropeptide 2 95.28 Very High Very High Very High
ischemia 100 90.68 High High
Pain 7 86.40 High High
Central nervous system 12 82.80 Quite High
backache 4 80.80 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 7 98.04 Very High Very High Very High
INFLAMMATION 33 96.32 Very High Very High Very High
Cv Unclassified Under Development 92 90.68 High High
Injury 37 84.12 Quite High
Pain 10 77.52 Quite High
Spinal Cord Injury 37 76.12 Quite High
Sciatic Neuropathy 32 53.84 Quite High
Brain Hemorrhage 6 50.00 Quite Low
Nervous System Injury 9 46.96 Quite Low
Low Back Pain 4 44.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PLF is strongly related to the downregulation of GAP43 and CGRP expression.
Negative_regulation (downregulation) of Gene_expression (expression) of GAP43 associated with calcitonin gene-related peptide
1) Confidence 0.58 Published 2010 Journal Eur Spine J Section Abstract Doc Link 20012755 Disease Relevance 0.17 Pain Relevance 0.68
This study was aimed at understanding the cellular and molecular mechanisms involved in oxaliplatin-induced neuropathy, and showed that adult rat DRG neurons treated with oxaliplatin in vitro, undergo dose-dependent loss of neurite length, density, Gap43 expression, and neuronal number (Figures 1, 2, 3).
Negative_regulation (loss) of in neurons Gene_expression (expression) of Gap43 in neurite associated with induced neuropathy and neuropathic pain
2) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC3003244 Disease Relevance 0.10 Pain Relevance 0.13
Expression of PKC substrate proteins, GAP-43 and neurogranin, is downregulated by cAMP signaling and alterations in synaptic activity.
Negative_regulation (downregulated) of Gene_expression (Expression) of GAP-43
3) Confidence 0.42 Published 2007 Journal Eur. J. Neurosci. Section Title Doc Link 18005072 Disease Relevance 0 Pain Relevance 0.18
The neutralization of endogenous BDNF with BDNF antibodies in vivo dramatically blocked the enhanced regeneration of sensory neurons and reduced the expression of GAP-43 in sensory neurons.
Negative_regulation (reduced) of Gene_expression (expression) of GAP-43 in sensory neurons associated with bdmf
4) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2246162 Disease Relevance 0.34 Pain Relevance 0.75
After 3-AB treatment, our results indicated that the expression of GAP-43 was significantly reduced in both P1 and P2 punches as compared to vehicle treated group of animals.
Negative_regulation (reduced) of Gene_expression (expression) of GAP-43
5) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779656 Disease Relevance 0.23 Pain Relevance 0.11
The expression of GAP-43 was found significantly repressed in P1 at 30 d (?
Negative_regulation (repressed) of Gene_expression (expression) of GAP-43
6) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779656 Disease Relevance 0.17 Pain Relevance 0.08

General Comments

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