INT147899

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Context Info
Confidence 0.30
First Reported 2007
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 2.07
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lpl) extracellular region (Lpl) plasma membrane (Lpl)
lipid metabolic process (Lpl)
Anatomy Link Frequency
liver 1
Lpl (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 38 99.38 Very High Very High Very High
tolerance 4 97.88 Very High Very High Very High
Opioid 2 97.66 Very High Very High Very High
Antinociceptive 4 97.48 Very High Very High Very High
Morphine 6 96.84 Very High Very High Very High
opioid receptor 2 95.00 High High
mu opioid receptor 10 93.40 High High
Intracerebroventricular 2 81.16 Quite High
agonist 72 67.40 Quite High
Inflammation 32 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 3 97.20 Very High Very High Very High
Obesity 419 96.16 Very High Very High Very High
Disease 23 94.84 High High
Atherosclerotic Plaque 28 89.84 High High
Atherosclerosis 89 87.24 High High
Systemic Lupus Erythematosus 1 86.28 High High
Hematological Disease 6 72.20 Quite High
Disorder Of Lipid Metabolism 11 58.16 Quite High
Autoimmune Disease 2 50.32 Quite High
Cancer 20 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that, in addition to the classical phenotypes, mutations of Kit induced juvenile steatosis, associated with the downregulation of the three genes, VldlR, Lpin1 and Lpl, controlling lipid metabolism in the post-natal liver.
Lpl Binding (associated) of in liver
1) Confidence 0.30 Published 2007 Journal BMC Dev Biol Section Abstract Doc Link PMC1940254 Disease Relevance 0.07 Pain Relevance 0
To determine whether the PI3K pathway was also involved in the cytokine-mediated reduction of Sp1/Sp3 binding to its recognition sequence in the LPL gene, the effect of pre-treatment of the cells with three different concentrations of the PI3K inhibitor LY294002 on the IFN-?
LPL gene Binding (binding) of associated with cytokine
2) Confidence 0.22 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.05
-mediated reduction of Sp1/Sp3 binding to the LPL gene.
LPL gene Binding (binding) of
3) Confidence 0.22 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.04
been formulated is that these antibodies might bind to LPL molecules on the surface
LPL Spec (might) Binding (bind) of
4) Confidence 0.08 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.78 Pain Relevance 0.03
Opioid-induced phosphorylation of PhLPl was impaired by inhibiting the activity of CaMKII and, in these circumstances, the association of PhLPl with Gbetagamma dimers and 14-3-3 proteins was diminished.
PhLPl Binding (association) of associated with opioid
5) Confidence 0.07 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18006024 Disease Relevance 0 Pain Relevance 0.77
It seems that CaMKII phosphorylation of PhLPl stabilizes the PhLPl.Gbetagamma complex by promoting its binding to 14-3-3 proteins.
PhLPl Binding (binding) of
6) Confidence 0.07 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18006024 Disease Relevance 0 Pain Relevance 0.76
at the LPL gene promoter is attenuated upon complex formation of ligand-bound PPAR?
LPL Binding (ligand) of
7) Confidence 0.05 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.38 Pain Relevance 0.09
at the LPL gene promoter is attenuated upon complex formation of ligand-bound PPAR?
LPL Binding (formation) of
8) Confidence 0.05 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.38 Pain Relevance 0.09
binding to the LPL promoter later in adipogenesis.
LPL Binding (binding) of
9) Confidence 0.05 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.44 Pain Relevance 0

General Comments

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