INT147900

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Context Info
Confidence 0.16
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lpl) extracellular region (Lpl) plasma membrane (Lpl)
lipid metabolic process (Lpl)
Anatomy Link Frequency
neural 1
Lpl (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 4 99.82 Very High Very High Very High
opioid receptor 4 99.32 Very High Very High Very High
tolerance 8 98.64 Very High Very High Very High
mu opioid receptor 20 98.40 Very High Very High Very High
Antinociceptive 8 98.24 Very High Very High Very High
Morphine 12 97.60 Very High Very High Very High
Intracerebroventricular 4 89.16 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It seems that CaMKII phosphorylation of PhLPl stabilizes the PhLPl.Gbetagamma complex by promoting its binding to 14-3-3 proteins.
Phosphorylation (phosphorylation) of PhLPl
1) Confidence 0.16 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18006024 Disease Relevance 0 Pain Relevance 0.76
Opioid-induced phosphorylation of PhLPl was impaired by inhibiting the activity of CaMKII and, in these circumstances, the association of PhLPl with Gbetagamma dimers and 14-3-3 proteins was diminished.
Phosphorylation (phosphorylation) of PhLPl associated with opioid
2) Confidence 0.16 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18006024 Disease Relevance 0 Pain Relevance 0.74
Additionally, neural PhLPl is subject to serine phosphorylation, which augments upon the activation of Mu-opioid receptors (MORs), as does its association with Gbetagamma subunits and 14-3-3 proteins.
Phosphorylation (phosphorylation) of PhLPl in neural associated with mu opioid receptor
3) Confidence 0.10 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18006024 Disease Relevance 0 Pain Relevance 0.50
Moreover, activated Ca2+/calmodulin-dependent protein kinase II (CaMKII) accumulated in the MOR environment and phosphorylated PhLPl was seen to co-precipitate with these opioid receptors.
Phosphorylation (phosphorylated) of PhLPl associated with opioid receptor
4) Confidence 0.10 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18006024 Disease Relevance 0 Pain Relevance 0.73

General Comments

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