INT147907

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 6.48
Pain Relevance 3.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lpl) extracellular region (Lpl) plasma membrane (Lpl)
lipid metabolic process (Lpl)
Anatomy Link Frequency
liver 2
adipocytes 1
Lpl (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 3 98.44 Very High Very High Very High
tolerance 63 97.64 Very High Very High Very High
Antinociceptive 6 97.24 Very High Very High Very High
Morphine 9 96.60 Very High Very High Very High
mu opioid receptor 15 96.48 Very High Very High Very High
Opioid 3 95.44 Very High Very High Very High
Intracerebroventricular 3 93.24 High High
cytokine 48 90.36 High High
alcohol 24 83.76 Quite High
Inflammation 184 81.04 Quite High
Disease Link Frequency Relevance Heat
Repression 6 99.80 Very High Very High Very High
Obesity 343 99.60 Very High Very High Very High
Disorder Of Lipid Metabolism 584 99.42 Very High Very High Very High
Retinoblastoma 1 94.56 High High
INFLAMMATION 203 81.04 Quite High
Atherosclerosis 153 79.16 Quite High
Vasculitis 3 78.08 Quite High
Weight Gain 46 75.20 Quite High
Disease 39 74.76 Quite High
Insulin Resistance 104 73.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The PI3K/mTOR pathway has previously been implicated in the insulin-mediated increase in LPL activity in adipocytes [37], and our studies extend this to transcriptional inhibition through Sp1/Sp3.
Positive_regulation (increase) of LPL in adipocytes associated with obesity
1) Confidence 0.29 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.39 Pain Relevance 0.05
target genes involved in triglycerides (TG) synthesis such as lipoprotein lipase (Lpl), phosphoenolpyruvate carboxykinase (PEPCK) and CD36 was significantly upregulated in ?
Positive_regulation (upregulated) of Lpl
2) Confidence 0.27 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0 Pain Relevance 0
target genes involved in triglycerides (TG) synthesis such as lipoprotein lipase (Lpl), phosphoenolpyruvate carboxykinase (PEPCK) and CD36 was significantly upregulated in ?
Positive_regulation (upregulated) of lipoprotein lipase
3) Confidence 0.27 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0 Pain Relevance 0
Gut bacteria also suppress the expression and release of fasting induced adipose factor (Fiaf) from small intestine, resulting in increased activity of lipoprotein-lipase (LPL) in adipocytes and enhanced storage of liver-derived triglycerides [12], [13].
Positive_regulation (increased) of lipoprotein-lipase in liver associated with obesity
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922379 Disease Relevance 1.29 Pain Relevance 0.19
The expression level of PEPCK and Lpl was significantly increased in both wt and ?
Positive_regulation (increased) of Lpl
5) Confidence 0.25 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.16 Pain Relevance 0
Gut bacteria also suppress the expression and release of fasting induced adipose factor (Fiaf) from small intestine, resulting in increased activity of lipoprotein-lipase (LPL) in adipocytes and enhanced storage of liver-derived triglycerides [12], [13].
Positive_regulation (activity) of lipoprotein-lipase in liver associated with obesity
6) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922379 Disease Relevance 1.24 Pain Relevance 0.17
The mechanisms, by which exercise and reduced weight increase HDL-C likely involves enchanced lipoprotein lipase (LL) activity, increased RCT, and increased levels of pre-?
Positive_regulation (increased) of lipoprotein lipase associated with disorder of lipid metabolism
7) Confidence 0.15 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.01 Pain Relevance 0.04
The mechanisms, by which exercise and reduced weight increase HDL-C likely involves enchanced lipoprotein lipase (LL) activity, increased RCT, and increased levels of pre-?
Positive_regulation (increased) of lipoprotein lipase associated with disorder of lipid metabolism
8) Confidence 0.10 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.02 Pain Relevance 0.04
It seems that CaMKII phosphorylation of PhLPl stabilizes the PhLPl.Gbetagamma complex by promoting its binding to 14-3-3 proteins.
Positive_regulation (stabilizes) of PhLPl
9) Confidence 0.10 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18006024 Disease Relevance 0 Pain Relevance 0.76
Moreover, activated Ca2+/calmodulin-dependent protein kinase II (CaMKII) accumulated in the MOR environment and phosphorylated PhLPl was seen to co-precipitate with these opioid receptors.
Positive_regulation (activated) of PhLPl associated with opioid receptor
10) Confidence 0.08 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18006024 Disease Relevance 0 Pain Relevance 0.74
Moreover, activated Ca2+/calmodulin-dependent protein kinase II (CaMKII) accumulated in the MOR environment and phosphorylated PhLPl was seen to co-precipitate with these opioid receptors.
Positive_regulation (accumulated) of PhLPl associated with opioid receptor
11) Confidence 0.08 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18006024 Disease Relevance 0 Pain Relevance 0.73
at the LPL gene promoter is attenuated upon complex formation of ligand-bound PPAR?
Positive_regulation (attenuated) of LPL
12) Confidence 0.07 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.38 Pain Relevance 0.09
The effects that PPAR alpha exerts on triglyceride-rich lipoproteins is due to their stimulation of lipoprotein lipase and repression of apolipoprotein CIII expression, while the effects on high-density lipoproteins depend upon the regulation of apolipoproteins AI and AII.
Positive_regulation (stimulation) of lipoprotein lipase associated with repression and disorder of lipid metabolism
13) Confidence 0.02 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 1.00 Pain Relevance 0.32

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