INT147909

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Context Info
Confidence 0.58
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 21
Total Number 23
Disease Relevance 9.35
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lpl) extracellular region (Lpl) plasma membrane (Lpl)
lipid metabolic process (Lpl)
Anatomy Link Frequency
macrophages 2
face 2
plasma 1
brain 1
fat 1
Lpl (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 120 99.72 Very High Very High Very High
cytokine 78 98.46 Very High Very High Very High
Inflammation 55 96.36 Very High Very High Very High
Bile 5 95.60 Very High Very High Very High
Inflammatory response 17 92.08 High High
abdominal pain 2 79.12 Quite High
tolerance 56 75.00 Quite High
Morphine 3 75.00 Quite High
Antinociceptive 2 75.00 Quite High
ischemia 5 71.44 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 133 99.88 Very High Very High Very High
Disorder Of Lipid Metabolism 628 99.70 Very High Very High Very High
Obesity 531 98.96 Very High Very High Very High
Diabetes Mellitus 75 97.84 Very High Very High Very High
Atherosclerosis 173 97.44 Very High Very High Very High
Vasculitis 1 96.36 Very High Very High Very High
Cytomegalovirus Infection 20 96.32 Very High Very High Very High
Disease 73 95.36 Very High Very High Very High
INFLAMMATION 73 92.08 High High
Lipodystrophy 2 91.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The LPL gene encodes lipoprotein lipase (EC 3.1.1.34) [35], an enzyme that hydrolyzes chylomicrons and very low-density lipoproteins (VLDL) into free fatty acids.
Gene_expression (encodes) of lipoprotein lipase associated with disorder of lipid metabolism
1) Confidence 0.58 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2978158 Disease Relevance 0.76 Pain Relevance 0.08
The LPL gene encodes lipoprotein lipase (EC 3.1.1.34) [35], an enzyme that hydrolyzes chylomicrons and very low-density lipoproteins (VLDL) into free fatty acids.
Gene_expression (encodes) of LPL gene associated with disorder of lipid metabolism
2) Confidence 0.58 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2978158 Disease Relevance 0.76 Pain Relevance 0.08
Sequencing of genomic DNA from the affected proband demonstrated no mutations in the coding regions of the LPL gene (data not shown), but did reveal 2 novel missense mutations in the ALMS1 gene – a G?
Gene_expression (regions) of LPL
3) Confidence 0.49 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266715 Disease Relevance 0.10 Pain Relevance 0
on the expression of LPL mRNA, protein and enzymatic activity [13].
Gene_expression (expression) of LPL mRNA
4) Confidence 0.45 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.05
on LPL gene expression is conserved in a range of macrophage sources, including primary cultures, along with other cellular systems (e.g. renal mesangial cells) [7–9,21], the human monocytic U937 cell line was employed for all transfection experiments.
Gene_expression (expression) of LPL gene in mesangial cells
5) Confidence 0.45 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.03
Transfection of U937 cells with an LPL promoter-luciferase DNA construct (? 
Gene_expression (Transfection) of LPL promoter
6) Confidence 0.39 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.30 Pain Relevance 0
target genes Lpl, PEPCK, CD36, and adiponectin was markedly decreased in adipose tissue from PPAR?
Gene_expression (genes) of Lpl in adipose tissue associated with obesity
7) Confidence 0.37 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.33 Pain Relevance 0.03
target genes (Lpl, PEPCK, CD36 and adiponectin) in gonadal fat isolated from these mice revealed no significant differences in the expression level between vehicle and DPN-treated rodents indicating ligand independency (Figure 4C).
Gene_expression (expression) of Lpl in fat
8) Confidence 0.37 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.06 Pain Relevance 0
The concentrations of these two cytokines used corresponded to those that produced a marked synergism at the level of LPL mRNA expression and enzymatic activity [13].


Gene_expression (expression) of LPL mRNA associated with cytokine
9) Confidence 0.35 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.18 Pain Relevance 0.14
-mediated suppression of LPL mRNA expression, protein levels and enzymatic activity has been observed in a range of macrophage sources from different species, including human monocyte-derived macrophages [7–9].
Gene_expression (expression) of LPL mRNA in macrophage
10) Confidence 0.35 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.46 Pain Relevance 0.03
The expression level of PEPCK and Lpl was significantly increased in both wt and ?
Gene_expression (expression) of Lpl
11) Confidence 0.33 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.16 Pain Relevance 0
To decipher the molecular basis of Kit-dependent steatosis, we determined the expression profiles of key genes involved in lipid hepatic metabolism: such as apoliproteins (Apoa1, ApoB), lipoprotein receptors (LdlR, VldlR, Scarb1, Lrp1), lipase (Lipc, LipH, Lpl) and others implicated in hepatic lipidogenesis (Scap, Srebf1, Srebf2), lipid secretion (Pltp, Mttp, Abca1), bile acid synthesis (Cyp8b1, Cyp7a1), lipid transport (Slc10a1, Abcb11, Abcb1a, Abcc2) and a lipodystrophy gene, Lipin 1 (Lpin1), encoding a phosphatidate phosphatase enzyme with transcription activity [26-28].
Spec (determined) Gene_expression (expression) of Lpl in bile associated with bile and lipodystrophy
12) Confidence 0.22 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.16 Pain Relevance 0.05
The long isoform of the phosducin-like protein (PhLPl) is widely expressed in the brain and it is thought to influence G-protein signalling by regulating the activity of Gbetagamma dimers.
Gene_expression (expressed) of PhLPl in brain
13) Confidence 0.15 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18006024 Disease Relevance 0 Pain Relevance 0.33
agonists enhance gene expression of SR BI, Apo AI, Apo AII, LPL, and ABCA1 (Toth 2005).
Gene_expression (expression) of LPL associated with agonist
14) Confidence 0.13 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.63 Pain Relevance 0.26
Clee et al. [28] have shown that, in double transgenic mice overexpressing LPL and CETP, HDL cholesterol levels were significantly influenced by the LPL activity while no such correlation was observed in the absence of CETP expression.
Gene_expression (overexpressing) of LPL associated with targeted disruption and disorder of lipid metabolism
15) Confidence 0.12 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31329 Disease Relevance 0.99 Pain Relevance 0
Others also have shown that FC transfer to HDL is a slow process: FC increases in the HDL fraction only 5 to 8 h after a fat meal [19] or only after 2 h incubation of HDL with VLDL and purified rat heart LPL [36].
Gene_expression (purified) of LPL in heart associated with disorder of lipid metabolism
16) Confidence 0.12 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31329 Disease Relevance 0.92 Pain Relevance 0
Nevertheless, expression of LPL remains robust in fully developed adipocytes [2, 18, 19], indicating that other factors sustain LPL expression in the face of reduced PPAR?
Gene_expression (expression) of LPL in face associated with obesity
17) Confidence 0.11 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.44 Pain Relevance 0
This could also explain the positive correlation between the lipoprotein lipase activity and HDL concentration in human plasma [20,21,22] but not in mice with genetically modified expression of LPL [23,24,28].
Gene_expression (expression) of LPL in plasma associated with disorder of lipid metabolism
18) Confidence 0.10 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31329 Disease Relevance 0.48 Pain Relevance 0
However, changes in the HDL-cholesterol concentration have not been observed in mice overexpressing LPL [23] or in LPL heterozygous knockout mice [24].
Gene_expression (overexpressing) of LPL associated with targeted disruption and disorder of lipid metabolism
19) Confidence 0.10 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31329 Disease Relevance 1.29 Pain Relevance 0
molecules such as apoE and lipoprotein lipase expressed on macrophages [94].
Gene_expression (expressed) of lipoprotein lipase in macrophages
20) Confidence 0.10 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.28 Pain Relevance 0

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