INT147960

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Context Info
Confidence 0.28
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 4.40
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GCLC) small molecule metabolic process (GCLC) cellular nitrogen compound metabolic process (GCLC)
ligase activity (GCLC) cytoplasm (GCLC)
Anatomy Link Frequency
Hepa-1c1c7 1
Murphy 1
GCLC (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 5 98.56 Very High Very High Very High
cva 2 88.24 High High
corticosteroid 38 80.88 Quite High
withdrawal 3 76.80 Quite High
Glutamate 4 76.20 Quite High
abdominal pain 1 73.24 Quite High
antagonist 8 50.00 Quite Low
Central nervous system 1 48.76 Quite Low
Inflammation 18 5.00 Very Low Very Low Very Low
aspirin 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 10 99.52 Very High Very High Very High
Asthma 78 99.46 Very High Very High Very High
Anaemia 5 96.64 Very High Very High Very High
Hemolytic Anemia 15 95.92 Very High Very High Very High
Syndrome 189 92.68 High High
Status Asthmaticus 1 90.84 High High
Hemorrhage 3 89.92 High High
Renal Failure 1 88.84 High High
Cv General 3 Under Development 2 88.24 High High
Myocardial Infarction 4 87.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GCS deficiency is a very rare autosomal recessive disorder reported so far in only 8 unrelated probands with severe haemolytic anaemia.
Negative_regulation (deficiency) of GCS associated with hemolytic anemia
1) Confidence 0.28 Published 2007 Journal Haematologica Section Abstract Doc Link 18024385 Disease Relevance 0.46 Pain Relevance 0.09
A previously undescribed mutation of hereditary gamma-glutamylcysteine synthetase (GCS) deficiency was found in a 5 year old boy of Moroccan origin.
Negative_regulation (deficiency) of GCS
2) Confidence 0.28 Published 2007 Journal Haematologica Section Abstract Doc Link 18024385 Disease Relevance 0.33 Pain Relevance 0
We report here the fourth case of GCS deficiency presenting neuropathy, giving further support to the eventual relationship between this enzymopathy and neurological damage.
Negative_regulation (deficiency) of GCS associated with neuropathic pain
3) Confidence 0.25 Published 2007 Journal Haematologica Section Abstract Doc Link 18024385 Disease Relevance 0.55 Pain Relevance 0.10
Accordingly, the measurement of de novo GSH synthetic enzymes was undertaken, and severe GCS deficiency was found in the propositus.
Negative_regulation (deficiency) of GCS
4) Confidence 0.25 Published 2007 Journal Haematologica Section Abstract Doc Link 18024385 Disease Relevance 0.32 Pain Relevance 0
Both parents and his sister presented GCS activity ranging from 69% to 90% of normal.
Negative_regulation (presented) of GCS
5) Confidence 0.25 Published 2007 Journal Haematologica Section Abstract Doc Link 18024385 Disease Relevance 0.42 Pain Relevance 0
In addition, GCLM (the light regulatory subunit of gamma-glutamylcysteine synthetase) was downregulated by curcumin with maximal downregulation by the low concentration of curcumin after 12 hours (1.8-fold) and by the high concentration of curcumin after 24 hours (1.9-fold).
Negative_regulation (downregulated) of gamma-glutamylcysteine synthetase
6) Confidence 0.17 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.14 Pain Relevance 0.04
Furthermore, the basal protein level of GCLC was decreased by 39 and 41% in cells transfected with si-SQSTM1 m3 and m4, respectively (Fig. 4B).
Negative_regulation (decreased) of GCLC
7) Confidence 0.13 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0.05 Pain Relevance 0
In keeping with its role as the rate-limiting enzyme in the synthesis of GSH, the functional significance of the decrease in basal mRNA and protein level of GCLC through depletion of SQSTM1 was demonstrated by the 17 and 16% decrease in the basal level of GSH in cells transfected with si-SQSTM1 m3 and m4, respectively (Fig. 4C).
Negative_regulation (decrease) of GCLC
8) Confidence 0.13 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0.07 Pain Relevance 0
In Hepa-1c1c7 cells transfected with si-SQSTM1 m3 and m4, the basal mRNA level of three Nrf2-regulated genes, heme oxygenase 1, GCLC, and NAD(P)H:quinone oxidoreductase 1, was reduced significantly, between 37 and 61% compared with si-CON-transfected cells (Fig. 4A).
Negative_regulation (reduced) of GCLC in Hepa-1c1c7
9) Confidence 0.07 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0 Pain Relevance 0
It has been noted to develop in steroid-dependent asthmatic patients where their oral GCS dose was reduced as they were successfully being treated with the LTRA (ie, Wechsler et al 1998; Kinoshita et al 1999; Michael and Murphy 2003).
Negative_regulation (reduced) of GCS in Murphy associated with asthma
10) Confidence 0.01 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661620 Disease Relevance 2.04 Pain Relevance 0.23

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