INT147970

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.88
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Smpd1) hydrolase activity, acting on glycosyl bonds (Smpd1) lysosome (Smpd1)
Anatomy Link Frequency
ASM 2
Smpd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 24 78.56 Quite High
Inflammatory response 2 66.84 Quite High
fluoxetine 2 35.44 Quite Low
Nortriptyline 2 32.80 Quite Low
Arthritis 1 25.56 Quite Low
rheumatoid arthritis 1 24.56 Low Low
Crohn's disease 1 23.68 Low Low
cytokine 18 11.72 Low Low
metalloproteinase 1 10.64 Low Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 31 95.68 Very High Very High Very High
INFLAMMATION 25 78.56 Quite High
Targeted Disruption 1 70.60 Quite High
Pneumonia 2 69.52 Quite High
Necrosis 3 50.00 Quite Low
Cancer 3 50.00 Quite Low
Hypersensitivity 4 43.92 Quite Low
Disease 5 28.04 Quite Low
Seronegative Spondarthritis 1 25.56 Quite Low
Rheumatoid Arthritis 1 24.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some organic weak bases induce a detachment from inner lysosomal membranes and subsequent inactivation of acid sphingomyelinase (ASM) and thus work as functional ASM inhibitors.
Positive_regulation (induce) of Positive_regulation (inactivation) of ASM
1) Confidence 0.43 Published 2008 Journal J. Med. Chem. Section Abstract Doc Link 18027916 Disease Relevance 0 Pain Relevance 0
Some organic weak bases induce a detachment from inner lysosomal membranes and subsequent inactivation of acid sphingomyelinase (ASM) and thus work as functional ASM inhibitors.
Positive_regulation (induce) of Positive_regulation (inactivation) of sphingomyelinase
2) Confidence 0.37 Published 2008 Journal J. Med. Chem. Section Abstract Doc Link 18027916 Disease Relevance 0 Pain Relevance 0
activation of ASM and contribute to the development of AHR.
Positive_regulation (contribute) of Positive_regulation (activation) of ASM in ASM
3) Confidence 0.23 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 0.88 Pain Relevance 0.15

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox