INT147971

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Smpd1) hydrolase activity, acting on glycosyl bonds (Smpd1) lysosome (Smpd1)
Smpd1 (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 2 76.16 Quite High
Nortriptyline 2 73.52 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The experimental data supported the requirement of an additional factor, which is necessary for functional inhibition of ASM.
Positive_regulation (necessary) of Negative_regulation (inhibition) of ASM
1) Confidence 0.43 Published 2008 Journal J. Med. Chem. Section Abstract Doc Link 18027916 Disease Relevance 0 Pain Relevance 0.11
Some organic weak bases induce a detachment from inner lysosomal membranes and subsequent inactivation of acid sphingomyelinase (ASM) and thus work as functional ASM inhibitors.
Positive_regulation (induce) of Negative_regulation (inactivation) of ASM
2) Confidence 0.40 Published 2008 Journal J. Med. Chem. Section Abstract Doc Link 18027916 Disease Relevance 0 Pain Relevance 0

General Comments

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