INT148

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Context Info
Confidence 0.70
First Reported 1975
Last Reported 2011
Negated 5
Speculated 4
Reported most in Abstract
Documents 182
Total Number 188
Disease Relevance 47.44
Pain Relevance 79.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gnrhr) signal transducer activity (Gnrhr)
Anatomy Link Frequency
plasma 46
blood 6
pituitary 4
thyroid 3
anterior pituitary 2
Gnrhr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 324 100.00 Very High Very High Very High
Morphine 145 100.00 Very High Very High Very High
agonist 79 100.00 Very High Very High Very High
Catecholamine 75 100.00 Very High Very High Very High
Somatostatin 73 100.00 Very High Very High Very High
noradrenaline 13 100.00 Very High Very High Very High
substance P 7 100.00 Very High Very High Very High
Delta opioid receptors 1 99.92 Very High Very High Very High
opiate 53 99.82 Very High Very High Very High
Sumatriptan 17 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 194 100.00 Very High Very High Very High
Burns 95 100.00 Very High Very High Very High
Syndrome 13 100.00 Very High Very High Very High
Acromegaly 10 100.00 Very High Very High Very High
Growth Hormone Deficiency 7 100.00 Very High Very High Very High
Hyperinsulinism 11 99.96 Very High Very High Very High
Hypoglycemia 86 99.92 Very High Very High Very High
Cancer 92 99.90 Very High Very High Very High
Reprotox - General 1 6 99.90 Very High Very High Very High
Thyroid Disease 1 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IP administration of various doses of clonidine produces significant increases in growth hormone levels in the Wistar rats but not in the Fawn-Hooded (FH) rats, a rat strain suggested to be a genetic model of depression.
Positive_regulation (increases) of growth hormone associated with depression, sprains and strains and clonidine
1) Confidence 0.70 Published 1994 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8029274 Disease Relevance 0.27 Pain Relevance 0.43
Administration of the dopaminergic agonists bromocriptine and L-dopa or the alpha-adrenergic receptor blocker phenoxybenzamine elevated GnRH-R acutely from average basal values of 240 +/- 22 and 254 +/- 21 fmol/mg protein to maximal values of 374 +/- 49, 441 +/- 67 and 461 +/- 75 fmol/mg, respectively, whereas the alpha-adrenergic agonist clonidine transiently decreased GnRH-R to 186 +/- 19 fmol/mg.
Positive_regulation (elevated) of GnRH-R associated with agonist and clonidine
2) Confidence 0.69 Published 1985 Journal Endocrinology Section Abstract Doc Link 2857637 Disease Relevance 0 Pain Relevance 0.97
In the latter model, this fall can be reproduced by administration of the opioid antagonist naloxone, whereas the opioid agonist morphine acutely increases GnRH-R.
Positive_regulation (increases) of GnRH-R associated with mu agonist, antagonist, narcan, opioid and morphine
3) Confidence 0.69 Published 1985 Journal Endocrinology Section Abstract Doc Link 2857637 Disease Relevance 0 Pain Relevance 0.78
Two other 5-HT1C/5-HT2 antagonists, ritanserin and mianserin, also attenuated (47%) clonidine-induced increases in growth hormone levels.
Positive_regulation (increases) of growth hormone associated with antagonist and clonidine
4) Confidence 0.69 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1356149 Disease Relevance 0.30 Pain Relevance 1.30
On the other hand, clonidine administration failed to increase growth hormone levels in the Fawn-Hooded rat strain.
Neg (failed) Positive_regulation (increase) of growth hormone associated with sprains and strains and clonidine
5) Confidence 0.69 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1356149 Disease Relevance 0.35 Pain Relevance 1.21
Pretreatment with the 5-hydroxytryptamine3 (5-HT3) receptor antagonist, MDL-72222, the 5-HT1A/5-HT2 antagonist, spiperone, and the mixed beta adrenergic/5-HT1B antagonists, l-propranolol and CGP361A, did not attenuate clonidine-induced increases in growth hormone levels.
Positive_regulation (increases) of growth hormone associated with antagonist and clonidine
6) Confidence 0.69 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1356149 Disease Relevance 0.15 Pain Relevance 1.09
Administration of various doses of clonidine increased plasma growth hormone levels.
Positive_regulation (increased) of plasma growth hormone in plasma associated with clonidine
7) Confidence 0.69 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1356149 Disease Relevance 0.15 Pain Relevance 0.61
Pretreatment with NMDA receptor antagonists including (+/-)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP/NMDA site), ifenprodril (polyamine site), and dizocilpine maleate (MK-801) or phencyclidine (PCP) (channel blockers) did not have any significant effect on clonidine-induced increases in growth hormone levels.
Positive_regulation (increases) of growth hormone associated with nmda receptor antagonist and clonidine
8) Confidence 0.69 Published 1995 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 7740072 Disease Relevance 0 Pain Relevance 0.71
Intraperitoneal administration of clonidine (50 micrograms/kg) produced increases in growth hormone levels in male Wistar rats.
Positive_regulation (increases) of growth hormone associated with clonidine
9) Confidence 0.69 Published 1995 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 7740072 Disease Relevance 0 Pain Relevance 0.51
The NMDA receptor complex modulates clonidine-induced increases in growth hormone levels in rats.
Positive_regulation (increases) of growth hormone associated with nmda receptor and clonidine
10) Confidence 0.69 Published 1995 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 7740072 Disease Relevance 0 Pain Relevance 0.70
In contrast, pretreatment with 5,7-dichlorokynurenic acid and 6,7-dinitroquinoxaline-2,3-dione (DNQX) (NMDA receptor-associated glycine site antagonists) significantly attenuated clonidine-induced increases in growth hormone levels.
Positive_regulation (increases) of growth hormone associated with glycine site antagonist, nmda receptor and clonidine
11) Confidence 0.69 Published 1995 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 7740072 Disease Relevance 0 Pain Relevance 0.75
After L-dopa administration, five children had low growth hormone secretion (M = 3.7 ng/ml, SD = 2.12 at 30 min) and three children had elevated growth hormone levels (> 30 ng/ml).
Positive_regulation (elevated) of growth hormone
12) Confidence 0.67 Published 1993 Journal Res Dev Disabil Section Abstract Doc Link 8210606 Disease Relevance 0.17 Pain Relevance 0.26
Dexmedetomidine dose-dependently increased plasma growth hormone and prolactin levels and decreased thyrotropin levels.
Positive_regulation (increased) of plasma growth hormone in plasma
13) Confidence 0.66 Published 1996 Journal Pharmacol. Toxicol. Section Abstract Doc Link 8882345 Disease Relevance 0 Pain Relevance 1.07
Serum prolactin and growth hormone levels were significantly elevated after i.v. injection of DAMME (14 micrograms kg-1) while a significant and considerably more prolonged increase occurred following i.c.v. administration of 20 micrograms of the analogue.
Positive_regulation (elevated) of growth hormone
14) Confidence 0.66 Published 1983 Journal Horm. Metab. Res. Section Abstract Doc Link 6141131 Disease Relevance 0 Pain Relevance 0.14
Chronic hydrocortisone treatment produced significant decreases in ACTH levels as well as a significant attenuation of clonidine-induced increases in growth hormone levels.
Positive_regulation (increases) of growth hormone associated with clonidine
15) Confidence 0.66 Published 1994 Journal Neuroendocrinology Section Abstract Doc Link 8145893 Disease Relevance 0 Pain Relevance 0.71
Similarly, chronic treatment with 5-HT uptake-inhibiting antidepressants such as fluoxetine, clomipramine and imipramine also significantly attenuated clonidine-induced increases in growth hormone levels.
Positive_regulation (increases) of growth hormone associated with antidepressant, clonidine and fluoxetine
16) Confidence 0.66 Published 1994 Journal Neuroendocrinology Section Abstract Doc Link 8145893 Disease Relevance 0 Pain Relevance 0.81
On the other hand, chronic treatment with clorgyline (monoamine oxidase type A-inhibiting antidepressant) and 5-HT agonists, such as m-chlorophenylpiperazine, 1-(2,5-dimethoxy-4- iodophenyl)-2-aminopropane and 8-hydroxy-2-(di-n-propylamino)tetralin, did not have any significant effect on clonidine-induced increases in growth hormone levels.
Positive_regulation (increases) of growth hormone associated with antidepressant, agonist, clonidine and monoamine
17) Confidence 0.66 Published 1994 Journal Neuroendocrinology Section Abstract Doc Link 8145893 Disease Relevance 0 Pain Relevance 0.80
Administration of various doses of clonidine increased plasma growth hormone levels in male Wistar rats.
Positive_regulation (increased) of plasma growth hormone in plasma associated with clonidine
18) Confidence 0.66 Published 1994 Journal Neuroendocrinology Section Abstract Doc Link 8145893 Disease Relevance 0 Pain Relevance 0.58
After the 6-h lag time, tolerance manifested to the thermal, locomotor depressant and hormonal (stimulation of growth hormone and prolactin secretion) effects of morphine.
Positive_regulation (stimulation) of growth hormone associated with tolerance and morphine
19) Confidence 0.64 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8846813 Disease Relevance 0 Pain Relevance 1.04
Intravenous administration of L-dopa produced a prompt, statistically significant increase in plasma growth hormone concentration.
Positive_regulation (increase) of plasma growth hormone in plasma
20) Confidence 0.62 Published 1976 Journal Neuroscience Section Abstract Doc Link 11370235 Disease Relevance 0 Pain Relevance 0.26

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