INT148026

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.54
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
DRG 1
Pik3cg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 5 98.46 Very High Very High Very High
substance P 10 98.12 Very High Very High Very High
qutenza 11 97.78 Very High Very High Very High
antagonist 5 88.48 High High
agonist 5 86.92 High High
cytokine 20 81.60 Quite High
Inflammation 13 77.68 Quite High
neuropeptide release 1 76.00 Quite High
vanilloid receptor subtype 1 2 75.00 Quite High
Root ganglion neuron 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 6 98.46 Very High Very High Very High
INFLAMMATION 13 77.68 Quite High
Adhesions 4 62.48 Quite High
Cardiovascular Disease 2 53.80 Quite High
Hyperplasia 5 52.96 Quite High
Death 7 39.28 Quite Low
Hyperglycemia 3 31.56 Quite Low
Cancer 4 31.44 Quite Low
Necrosis 1 30.96 Quite Low
Diabetes Mellitus 14 30.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This in turn triggers a cascade of intracellular signalling pathways such as signal transducers and activators of transcription (STAT) 5, Ras-Raf-MAP kinase, and mTOR/P13-K/p70 S6 kinase activation.
Positive_regulation (activation) of P13-K
1) Confidence 0.45 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.20 Pain Relevance 0.22
In summary, the activation of TRPV1 by capsaicin modulates the SP release from DRG neurons via two different mechanisms, one requiring extracellular Ca2+, the activation of PI3K and the IP3-dependent intracellular Ca2+ release, and the other which is independent of extracellular Ca2+ but involves the activation of MEK.
Positive_regulation (activation) of PI3K in DRG associated with dorsal root ganglion, qutenza and substance p
2) Confidence 0.38 Published 2008 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 18034335 Disease Relevance 0.23 Pain Relevance 1.07
Namely, it has been known that insulin receptor signaling results in activation of PI3K and a variety of downstream effectors, including Akt, mTOR, and P70S6K, after insulin binds to insulin receptors located on the cell membrane.
Positive_regulation (activation) of PI3K
3) Confidence 0.27 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.11 Pain Relevance 0.04
BDNF-mediated MEK/ERK activation is universally required for gene induction while PI3K, CAMK and NOS activation co-regulate induction on a gene-specific basis
Positive_regulation (activation) of PI3K
4) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669182 Disease Relevance 0 Pain Relevance 0.13

General Comments

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