INT148070

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Context Info
Confidence 0.08
First Reported 2006
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 9.46
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
cartilage 4
chondrocytes 3
plasma 1
osteoblasts 1
lumen 1
Ppi-rs (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 180 99.52 Very High Very High Very High
nMDA receptor antagonist 1 99.52 Very High Very High Very High
Dopamine 3 98.44 Very High Very High Very High
depression 30 90.52 High High
cytokine 37 89.16 High High
agonist 1 77.64 Quite High
dopamine receptor 1 77.32 Quite High
Enkephalin 1 72.32 Quite High
bradykinin 1 71.20 Quite High
Eae 21 39.32 Quite Low
Disease Link Frequency Relevance Heat
Osteoarthritis 180 99.52 Very High Very High Very High
Calcification 552 99.40 Very High Very High Very High
Aging 156 99.32 Very High Very High Very High
Chondrocalcinosis 36 99.14 Very High Very High Very High
Disease 98 96.16 Very High Very High Very High
Parkinson's Disease 12 95.88 Very High Very High Very High
Syndrome 12 92.40 High High
Depression 30 90.52 High High
Metabolic Disorder 12 88.68 High High
Targeted Disruption 27 87.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of these mice with apomorphine, the dopamine releaser, amphetamine or the NMDA receptor antagonist, MK-801, significantly disrupted PPI.
Positive_regulation (disrupted) of PPI associated with nmda receptor antagonist and dopamine
1) Confidence 0.08 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18037452 Disease Relevance 0.29 Pain Relevance 0.28
We refuted this work [52], and in so doing, we demonstrated that increased expression of one of 2 CILP isoforms (CILP-1) in aging cartilage interferes with the regulatory effects of IGF-I on PPi metabolism, thereby promoting increased extracellular PPi and cartilage calcification.


Positive_regulation (increased) of PPi in cartilage associated with calcification and aging
2) Confidence 0.07 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.82 Pain Relevance 0.07
NPP1 not only directly induces elevated PPi but also matrix calcification by chondrocytes in vitro.
Positive_regulation (elevated) of PPi in chondrocytes associated with calcification
3) Confidence 0.07 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.64 Pain Relevance 0.27
Correspondingly, we have observed that direct expression of NPP2 did not increase extracellular PPi in chondrocytes, under conditions in which NPP2 did stimulate both alkaline phosphatase and increased calcification [12].
Neg (not) Positive_regulation (increase) of PPi in chondrocytes associated with calcification
4) Confidence 0.05 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.21 Pain Relevance 0
We refuted this work [52], and in so doing, we demonstrated that increased expression of one of 2 CILP isoforms (CILP-1) in aging cartilage interferes with the regulatory effects of IGF-I on PPi metabolism, thereby promoting increased extracellular PPi and cartilage calcification.


Positive_regulation (increased) of PPi in cartilage associated with calcification and aging
5) Confidence 0.05 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.82 Pain Relevance 0.07
In cells such as osteoblasts and chondrocytes that normally express NPP1 relatively robustly, NPP1 and NPP3 increase intracellular PPi, suspected to be in large part in the lumen of the ER and Golgi [12, 16, 31].
Positive_regulation (increase) of PPi in lumen
6) Confidence 0.05 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.32 Pain Relevance 0.05
Furthermore, the marked depletion of extracellular PPi and of osteopontin, the rapid, extensive calcification by both NPP1-/- and ank/ank osteoblasts in culture are corrected by soluble NPP1, reinforcing a central role of NPP1 in skeletal PPi and Pi metabolism and osteopontin expression [18], a notion strongly supported by in vivo studies [21, 33].
Positive_regulation (role) of PPi in osteoblasts associated with calcification
7) Confidence 0.05 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.42 Pain Relevance 0.05
Significantly increased NPP activity and extracellular PPi develop concurrent with the ATPdepleted state [48].
Positive_regulation (increased) of PPi
8) Confidence 0.05 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.53 Pain Relevance 0.09
In idiopathic chondrocalcinosis of aging and in OA, there are substantial increases in joint fluid PPi derived largely from cartilage.
Positive_regulation (increases) of PPi in cartilage associated with chondrocalcinosis, aging and osteoarthritis
9) Confidence 0.05 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.70 Pain Relevance 0.28
induces both NPP1 expression and elevation of extracellular PPi [12, 31, 43].
Positive_regulation (elevation) of PPi
10) Confidence 0.05 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.61 Pain Relevance 0.13
to increase cartilage NPP activity and extracellular PPi levels directly correlates with donor age [12, 31, 44].
Positive_regulation (increase) of PPi in cartilage
11) Confidence 0.05 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.59 Pain Relevance 0.13
-stimulated cellular program for chondrocyte extracellular PPi elevation includes substantial increases in ATP generation [45] and stimulation of NPP1 movement to the plasma membrane [12, 31].
Positive_regulation (elevation) of PPi in plasma
12) Confidence 0.05 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.66 Pain Relevance 0.12
expression and responsiveness, which drives PPi generation and release mediated via NPP1 and ANK, and diminished responsiveness to IGF-I, which normally suppresses elevation of chondrocyte extracellular PPi.
Positive_regulation (elevation) of PPi in chondrocyte
13) Confidence 0.05 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.76 Pain Relevance 0.11
The percentage PPI induced by each prepulse intensity was calculated as [1-(startle amplitude on prepulse trial)/(startle amplitude on pulse alone)] × 100%.
Positive_regulation (induced) of PPI
14) Confidence 0.04 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.06 Pain Relevance 0

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