INT148071

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Context Info
Confidence 0.74
First Reported 2007
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 42
Total Number 53
Disease Relevance 44.90
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agt) extracellular matrix organization (Agt)
Anatomy Link Frequency
liver 7
blood 3
Hepatocytes 2
fat 2
cleavage 1
Agt (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 37 99.98 Very High Very High Very High
bradykinin 45 99.96 Very High Very High Very High
substance P 8 99.92 Very High Very High Very High
Inflammation 168 99.80 Very High Very High Very High
Enkephalin 8 99.76 Very High Very High Very High
Neuropeptide 4 99.66 Very High Very High Very High
antagonist 105 98.88 Very High Very High Very High
palliative 13 98.76 Very High Very High Very High
Dopamine 13 93.92 High High
nMDA receptor antagonist 1 90.88 High High
Disease Link Frequency Relevance Heat
Cancer 978 99.88 Very High Very High Very High
Colon Cancer 1019 99.84 Very High Very High Very High
INFLAMMATION 170 99.80 Very High Very High Very High
Cognitive Disorder 186 99.78 Very High Very High Very High
Metastasis 973 99.76 Very High Very High Very High
Obesity 79 99.68 Very High Very High Very High
Coronary Artery Disease 150 99.48 Very High Very High Very High
Pre-eclampsia 506 99.34 Very High Very High Very High
Targeted Disruption 90 99.32 Very High Very High Very High
Metabolic Syndrome 105 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The neuropeptide angiotensin II (ANGII) and its cognate receptor AT1, are both expressed by SCN cells, but unlike other SCN neurochemicals, very little is known about the cellular actions of ANGII within this circadian clock.
Gene_expression (expressed) of ANGII associated with neuropeptide
1) Confidence 0.74 Published 2008 Journal Neuroscience Section Abstract Doc Link 18479832 Disease Relevance 0 Pain Relevance 0.12
We examined the difference for the main characteristics between the 5-HT2A, 5-HTT, AGT, ACE, and AT1R genotypes in the 205 patients without sarcomeric mutations.
Gene_expression (genotypes) of AGT
2) Confidence 0.65 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 0.57 Pain Relevance 0
The genotyping of the 5-HT2A, 5-HTT, AGT, ACE, and AT1R polymorphisms showed a significantly higher frequency of carriers of the AT1R C allele (AC+CC genotypes) in the HCM patients without sarcomeric gene mutations compared to the healthy controls (p = 0.015; OR = 1.56; 95% CI = 1.09-2.23) (Table 2).
Gene_expression (genotyping) of AGT associated with hypertrophic cardiomyopathy
3) Confidence 0.65 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 0.81 Pain Relevance 0
Likewise, both hyperglycemia and insulin activate the RAS by increasing expression of angiotensinogen, Ang II, and regulation and activity of the angiotensin type 1 (AT1) receptor.
Gene_expression (expression) of angiotensinogen associated with hyperglycemia
4) Confidence 0.62 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 1.09 Pain Relevance 0.04
Likewise, both hyperglycemia and insulin activate the RAS by increasing expression of angiotensinogen, Ang II, and regulation and activity of the angiotensin type 1 (AT1) receptor.
Gene_expression (expression) of Ang II associated with hyperglycemia
5) Confidence 0.62 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 1.09 Pain Relevance 0.04
It is likely that increased APA and P-LAP activity in maternal sera before, and immediately after, the appearance of preeclampsia is in response to the increased production of AngII/AVP from the fetus.
Gene_expression (production) of AngII associated with pre-eclampsia
6) Confidence 0.62 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.63 Pain Relevance 0.09
Taken together, these findings present a treatment dilemma since the increased synthesis of AngII by the fetus significantly contributes to preeclampsia; while vasoconstriction of the fetoplacental circulation may be of primary importance in preeclampsia [70].
Gene_expression (synthesis) of AngII associated with increased venous pressure under development and pre-eclampsia
7) Confidence 0.62 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 1.04 Pain Relevance 0
The renin-angiotensin system (RAS) is recognized as an important contributor to hypertension [22], and the majority of research concerned with this system has focused on the synthesis of AngII and its interaction with angiotensin receptors [23].
Gene_expression (synthesis) of AngII associated with hypertension
8) Confidence 0.62 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.56 Pain Relevance 0.03
The gradient of AngII between umbilical venous and arterial blood suggests the active involvement of placental angiotensin-converting enzyme (ACE) (EC 3.4.15.1) in AngII production in the fetoplacental unit.
Gene_expression (production) of AngII in blood
9) Confidence 0.62 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.53 Pain Relevance 0
The antihypertensive effects of APA and candesartan were maintained by increasing the dose with advancing gestation, suggesting that AngII synthesis increases over time in pregnant SHRs.
Gene_expression (synthesis) of AngII
10) Confidence 0.62 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.30 Pain Relevance 0
The levels of AngII in umbilical venous blood was found to be higher than those in umbilical arterial blood in normal pregnancy and preeclampsia, and the levels in both umbilical and maternal venous blood in cases of severe preeclampsia were also much higher than those measured during normal pregnancy.
Gene_expression (levels) of AngII in blood associated with pre-eclampsia
11) Confidence 0.62 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.69 Pain Relevance 0
Kingdom and colleagues [2] investigated the relation between umbilical arterial oxygen partial pressure and AngII levels in the umbilical vein during human delivery.
Gene_expression (levels) of AngII in umbilical vein
12) Confidence 0.62 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.58 Pain Relevance 0
ANG II, the main circulating effector hormone of the renin-angiotensin system, is produced by enzymatic cleavage of angiotensinogen.
Gene_expression (produced) of ANG II in cleavage
13) Confidence 0.60 Published 2010 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 19939975 Disease Relevance 0.14 Pain Relevance 0.09
While they block the AT1 receptor and negative many of the ill effects of Ang II, there is a paucity of information about the long term effects of elevated Ang II levels on the AT2 receptors.
Gene_expression (levels) of Ang II
14) Confidence 0.54 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.39 Pain Relevance 0.13
KO mice on both P-LAP and APA showed that OT and AngII sensitivity is regulated by both aminopeptidases.

8.

Gene_expression (sensitivity) of AngII
15) Confidence 0.53 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.23 Pain Relevance 0
As expected, APA E360Q did not show any hydrolytic activity against the fluorogenic synthetic substrate Glu-MCA or AngII (data not shown).
Gene_expression (synthetic) of AngII
16) Confidence 0.53 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.14 Pain Relevance 0.03
We used multi-electrode, multiunit, extracellular electrophysiology, coupled with whole-cell voltage and current clamp techniques to investigate the actions of ANGII in mouse SCN slices.
Spec (investigate) Gene_expression (actions) of ANGII
17) Confidence 0.50 Published 2008 Journal Neuroscience Section Abstract Doc Link 18479832 Disease Relevance 0 Pain Relevance 0.19
The activation of the renal renin angiotensin system (RAS), characterized by elevated ACE expression and increased local angiotensin (Ang) II production, has been found in many human kidney diseases [3].
Gene_expression (production) of angiotensin in kidney associated with renal disease
18) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672164 Disease Relevance 0.88 Pain Relevance 0.17
Although increased circulating levels of AngII in APA KO mice result in hypertension, it may not stimulate the synthesis of growth factor-?
Gene_expression (levels) of AngII associated with hypertension
19) Confidence 0.48 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.53 Pain Relevance 0
It is well known that the fetus produces bioactive peptides such as angiotensin II (AngII), vasopressin (AVP), and oxytocin (OT), that are highly vasoactive and uterotonic, respectively [1–4].
Gene_expression (produces) of AngII
20) Confidence 0.48 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.17 Pain Relevance 0

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