INT148072

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 13
Disease Relevance 9.41
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Agtr1a) signal transduction (Agtr1a) Golgi apparatus (Agtr1a)
plasma membrane (Agtr1a) cytoplasm (Agtr1a) signal transducer activity (Agtr1a)
Anatomy Link Frequency
brain 2
blood vessels 1
Agtr1a (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 2 99.02 Very High Very High Very High
Dopamine 2 94.32 High High
long-term potentiation 1 93.04 High High
nMDA receptor antagonist 2 91.28 High High
Hippocampus 1 87.12 High High
agonist 3 86.24 High High
dopamine receptor 2 85.92 High High
antagonist 68 81.20 Quite High
Inflammation 38 65.60 Quite High
fibrosis 3 60.48 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 189 100.00 Very High Very High Very High
Apoptosis 141 98.80 Very High Very High Very High
Cancer 756 98.48 Very High Very High Very High
Targeted Disruption 9 98.28 Very High Very High Very High
Disease 22 78.64 Quite High
Schizophrenia 4 78.48 Quite High
Pressure And Volume Under Development 9 77.76 Quite High
Malignant Neoplastic Disease 27 77.44 Quite High
Metastasis 9 77.00 Quite High
Ureteral Obstruction 42 73.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We used renin-enhancer knockout (REKO) mice, which display reduced renin activity, and neuron-specific enolase (NSE)-AT1A mice, which selectively over-express angiotensin AT1A receptors in the brain.
Gene_expression (express) of AT1A in brain associated with targeted disruption
1) Confidence 0.75 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18037452 Disease Relevance 0.32 Pain Relevance 0.27
We used renin-enhancer knockout (REKO) mice, which display reduced renin activity, and neuron-specific enolase (NSE)-AT1A mice, which selectively over-express angiotensin AT1A receptors in the brain.
Gene_expression (over-express) of AT1A in brain associated with targeted disruption
2) Confidence 0.65 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18037452 Disease Relevance 0.33 Pain Relevance 0.26
First suggestions that the Mas gene codes for an Ang II-sensitive receptor [12] have been corrected by findings that alterations in intracellular Ca2+-concentrations in Mas-transfected cells after Ang II treatment could only be confirmed in cells expressing the Ang II receptor AT1 endogenously [13], [14].
Gene_expression (expressing) of AT1
3) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672164 Disease Relevance 0.70 Pain Relevance 0.26
The neuropeptide angiotensin II (ANGII) and its cognate receptor AT1, are both expressed by SCN cells, but unlike other SCN neurochemicals, very little is known about the cellular actions of ANGII within this circadian clock.
Gene_expression (expressed) of AT1 associated with neuropeptide
4) Confidence 0.52 Published 2008 Journal Neuroscience Section Abstract Doc Link 18479832 Disease Relevance 0 Pain Relevance 0.12
The AT1 receptor is widely expressed in a variety of adult tissues.
Gene_expression (expressed) of AT1
5) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 1.29 Pain Relevance 0
While AT1 receptor over-expression has been implicated in many types of cancers including pancreatic cáncer [11,12,38,39], the specific role of the AT2 receptor in carcinogenesis has not been rigorously elucidated.
Gene_expression (over) of AT1 associated with cancer
6) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.38 Pain Relevance 0.07
In support of this speculation, Fujimoto et al. [39] have reported AT1 receptor over-expression in human pancreatic cancer tissues and AT1 receptor-mediated growth regulation in pancreatic cancer cells.
Gene_expression (expression) of AT1 associated with pancreatic cancer
7) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 1.20 Pain Relevance 0
In support of this speculation, Fujimoto et al. [39] have reported AT1 receptor over-expression in human pancreatic cancer tissues and AT1 receptor-mediated growth regulation in pancreatic cancer cells.
Gene_expression (over) of AT1 associated with pancreatic cancer
8) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 1.19 Pain Relevance 0
In support of this speculation, Fujimoto et al. [39] have reported AT1 receptor over-expression in human pancreatic cancer tissues and AT1 receptor-mediated growth regulation in pancreatic cancer cells.
Gene_expression (-) of AT1 associated with pancreatic cancer
9) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 1.19 Pain Relevance 0
The major isoform, the AT1 receptor, is expressed in a wide variety of tissues, and its signaling functions in a variety of pathophysiological reactions, including constriction of blood vessels, induction of cell proliferation and expression of proto-oncogenes such as c-fos, c-myc and c-jun [46].
Gene_expression (expressed) of AT1 in blood vessels
10) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.86 Pain Relevance 0
In support of this speculation, Fujimoto et al. [39] have reported AT1 receptor over-expression in human pancreatic cancer tissues and AT1 receptor-mediated growth regulation in pancreatic cancer cells.
Gene_expression (expression) of AT1 associated with pancreatic cancer
11) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 1.19 Pain Relevance 0
While AT1 receptor over-expression has been implicated in many types of cancers including pancreatic cáncer [11,12,38,39], the specific role of the AT2 receptor in carcinogenesis has not been rigorously elucidated.
Gene_expression (-) of AT1 associated with cancer
12) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.38 Pain Relevance 0.07
While AT1 receptor over-expression has been implicated in many types of cancers including pancreatic cáncer [11,12,38,39], the specific role of the AT2 receptor in carcinogenesis has not been rigorously elucidated.
Gene_expression (expression) of AT1 associated with cancer
13) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.38 Pain Relevance 0.07

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