INT148074

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.42
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agt) extracellular matrix organization (Agt)
Anatomy Link Frequency
liver 1
brains 1
smooth muscle cells 1
Agt (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 16 100.00 Very High Very High Very High
antagonist 14 99.02 Very High Very High Very High
palliative 1 91.16 High High
bradykinin 21 86.88 High High
substance P 4 86.56 High High
chemokine 2 85.00 Quite High
Eae 4 84.60 Quite High
Onset of action 2 80.04 Quite High
Inflammation 44 79.48 Quite High
dopamine receptor 1 66.32 Quite High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 92 99.84 Very High Very High Very High
Coronary Heart Disease 36 99.52 Very High Very High Very High
Hypertrophic Cardiomyopathy 42 99.08 Very High Very High Very High
Hyperglycemia 12 98.26 Very High Very High Very High
Schizophrenia 2 97.84 Very High Very High Very High
Cancer 61 97.80 Very High Very High Very High
Insulin Resistance 17 97.04 Very High Very High Very High
Increased Venous Pressure Under Development 55 96.16 Very High Very High Very High
Coronary Stenosis 1 95.32 Very High Very High Very High
Left Ventricular Hypertrophy 19 94.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Likewise, both hyperglycemia and insulin activate the RAS by increasing expression of angiotensinogen, Ang II, and regulation and activity of the angiotensin type 1 (AT1) receptor.
Regulation (regulation) of angiotensin associated with hyperglycemia
1) Confidence 0.49 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 1.08 Pain Relevance 0.04
While they block the AT1 receptor and negative many of the ill effects of Ang II, there is a paucity of information about the long term effects of elevated Ang II levels on the AT2 receptors.
Regulation (effects) of Ang II
2) Confidence 0.22 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.39 Pain Relevance 0.13
Regulation of the renin–angiotensin system in coronary atherosclerosis: A review of the literature

Activation of the renin–angiotensin system (RAS) is significant in the pathogenesis of cardiovascular disease and specifically coronary atherosclerosis.

Regulation (Regulation) of angiotensin system associated with coronary artery disease and cardiovascular disease
3) Confidence 0.19 Published 2007 Journal Vascular Health and Risk Management Section Title Doc Link PMC2350139 Disease Relevance 0.59 Pain Relevance 0
Changes in the levels of angiotensin-converting enzyme (ACE) have been found in brains of schizophrenia patients, suggesting a possible involvement of angiotensin in the illness.
Regulation (Changes) of angiotensin in brains associated with schizophrenia
4) Confidence 0.14 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18037452 Disease Relevance 0.25 Pain Relevance 0.07
Considering the role of the serotonin and angiotensin systems in cardiac hypertrophy, we hypothesized that DNA variants in the 5-HT2A, 5-HTT, AGT, ACE, and AT1R genes could influence the risk for LVH.
Regulation (role) of angiotensin associated with left ventricular hypertrophy, coronary heart disease and serotonin
5) Confidence 0.12 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 1.40 Pain Relevance 0.08
If it is a competitive substrate, it would be difficult to explain the observed effects of the AT4 receptor antagonist divalinal, which is known to not only block the effects of angiotensin IV, but also have detrimental effects on learning and memory: does divalinal enhance IRAP activity?
Regulation (effects) of angiotensin IV associated with antagonist
6) Confidence 0.11 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604899 Disease Relevance 0.16 Pain Relevance 0.17
This was not the first demonstration of an effect of angiotensin IV on learning and memory.
Regulation (effect) of angiotensin IV
7) Confidence 0.11 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604899 Disease Relevance 0.24 Pain Relevance 0.04
AT II binds to and regulates vascular smooth muscle cells tone via specific angiotensin receptors (Studdy et al 1983).
Regulation (regulates) of angiotensin in smooth muscle cells
8) Confidence 0.05 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 0.39 Pain Relevance 0.09
Experimental animal models show a stimulatory effect of the key RAS peptide angiotensin (ANG) II through the ANG II type 1 receptor (AT1R) on tumour growth, while blockade this pathway inhibits tumour growth[6,7], including in a mouse model of CRC liver metastases [8].
Regulation (effect) of angiotensin in liver associated with cancer, colon cancer and metastasis
9) Confidence 0.02 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 0.93 Pain Relevance 0.09

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