INT148085

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Context Info
Confidence 0.32
First Reported 2002
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 10.22
Pain Relevance 3.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL10) extracellular space (CXCL10) extracellular region (CXCL10)
cell-cell signaling (CXCL10)
Anatomy Link Frequency
epithelial cells 2
monocyte 1
fibroblasts 1
eosinophils 1
lung 1
CXCL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 273 100.00 Very High Very High Very High
chemokine 226 99.76 Very High Very High Very High
Inflammation 231 99.20 Very High Very High Very High
Inflammatory response 8 99.08 Very High Very High Very High
Arthritis 146 92.68 High High
agonist 9 85.76 High High
antagonist 55 82.64 Quite High
pulpitis 2 73.28 Quite High
Sicca syndrome 3 61.76 Quite High
psoriasis 8 55.40 Quite High
Disease Link Frequency Relevance Heat
Infection 99 99.68 Very High Very High Very High
INFLAMMATION 251 99.20 Very High Very High Very High
Granuloma 12 99.10 Very High Very High Very High
Pulmonary Disease 122 98.76 Very High Very High Very High
Eye Disease 196 96.28 Very High Very High Very High
Bacterial Infection 7 95.52 Very High Very High Very High
Arthropathy 6 94.84 High High
Syndrome 14 93.64 High High
Cancer 28 93.28 High High
Necrosis 22 93.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cytokine IP-10 (CXCL10) was found to be present in the highest concentration of all tested cytokines.
CXCL10 Binding (found) of associated with cytokine
1) Confidence 0.32 Published 2010 Journal Respir Res Section Body Doc Link PMC2923116 Disease Relevance 0.10 Pain Relevance 0.27
Cytokine IP-10 (CXCL10) was found to be present in the highest concentration of all tested cytokines.
IP-10 Binding (found) of associated with cytokine
2) Confidence 0.32 Published 2010 Journal Respir Res Section Body Doc Link PMC2923116 Disease Relevance 0.10 Pain Relevance 0.27
Abbreviations: CXCL10, CXC chemokine ligand 10; CXCR3, CXC chemokine receptor 3; IFN, interferon; FBS, fetal bovine serum; LTA, lipoteichoic acid; PGN, peptidoglycan; IL, interleukin; TNF, tumor necrosis factor; PBS, phosphate-buffered saline; ELISA, enzyme-linked immunosorbent assay; CCL, C-C chemokine ligand; TLR, Toll-like receptor; NOD, nucleotide oligomerization domain; HDPF, human dental pulp fibroblasts.
CXCL10 Binding (Abbreviations) of in fibroblasts associated with chemokine, necrosis and cancer
3) Confidence 0.32 Published 2007 Journal J. Dent. Res. Section Abstract Doc Link 18037659 Disease Relevance 0.47 Pain Relevance 0.50
Coexpression and interaction of CXCL10 and CD26 in mesenchymal cells by synergising inflammatory cytokines: CXCL8 and CXCL10 are discriminative markers for autoimmune arthropathies

Leukocyte infiltration during acute and chronic inflammation is regulated by exogenous and endogenous factors, including cytokines, chemokines and proteases.

CXCL10 Binding (interaction) of in mesenchymal cells associated with chemokine, inflammation, arthropathy and cytokine
4) Confidence 0.31 Published 2006 Journal Arthritis Res Ther Section Title Doc Link PMC1779382 Disease Relevance 0.54 Pain Relevance 0.38
These findings are particularly interesting in view of the angiogenic and antiangiogenic activities of CXCL8 and CXCL10, respectively.
CXCL10 Binding (activities) of
5) Confidence 0.31 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0 Pain Relevance 0.13
Human conjunctival epithelial cells in vitro secrete significantly increased amounts of IP-10/CXCL10 when stimulated by TNF-?
IP-10 Binding (amounts) of in epithelial cells
6) Confidence 0.28 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 1.39 Pain Relevance 0.28
Human conjunctival epithelial cells in vitro secrete significantly increased amounts of IP-10/CXCL10 when stimulated by TNF-?
CXCL10 Binding (amounts) of in epithelial cells
7) Confidence 0.28 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 1.39 Pain Relevance 0.28
IP-10/ CXCL10 binds to cells through the CXCR3 receptor, which is preferentially expressed in Th1 cells as well as in eosinophils.
CXCL10 Binding (binds) of in eosinophils
8) Confidence 0.27 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 1.83 Pain Relevance 0.40
, ligands for CCR5, and CXCL10 (also known as IFN?
CXCL10 Binding (ligands) of
9) Confidence 0.26 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.96 Pain Relevance 0.67
, TRAIL, CXCL10, and OSM) that we found prominently expressed in HMB-PP-stimulated monocyte-??
CXCL10 Binding (found) of in monocyte
10) Confidence 0.18 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0.61 Pain Relevance 0.03
Specific inhibitors of CXCL10/CXCR3 interaction might therefore be useful for COPD treatment.
CXCL10 Binding (interaction) of associated with pulmonary disease
11) Confidence 0.13 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 1.09 Pain Relevance 0.35
The genes for complement C3 and IP-10 (IFN-induced protein of 10 kDa), a non-ELR CXC chemokine, were among the genes upregulated by IL-4 in the monkey lung.
IP-10 Binding (complement) of in lung associated with chemokine
12) Confidence 0.12 Published 2002 Journal Genome Biol Section Body Doc Link PMC115222 Disease Relevance 0 Pain Relevance 0.05
DCs infection with DEN-2 and endogenous IP-10 neutralizing experiments
IP-10 Binding (endogenous) of associated with infection
13) Confidence 0.08 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 0.34 Pain Relevance 0.04
The maintenance of the granuloma may be through the IL-12, and resolution is associated with the cytokine IL-10, which suppresses the inflammatory response (Moller et al 1996).
cytokine IL-10 Binding (associated) of associated with inflammatory response, granuloma and cytokine
14) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643111 Disease Relevance 1.40 Pain Relevance 0.15

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