INT148087

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Context Info
Confidence 0.17
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.13
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (RTEL1) helicase activity (RTEL1) DNA binding (RTEL1)
Anatomy Link Frequency
B-cell 1
submandibular lymph node 1
RTEL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 16 86.16 High High
Arthritis 26 83.52 Quite High
Inflammation 8 57.80 Quite High
cINOD 2 50.00 Quite Low
alcohol 2 27.48 Quite Low
cytokine 8 25.00 Low Low
backache 2 22.68 Low Low
COX2 1 10.00 Low Low
Antihistamine 10 5.00 Very Low Very Low Very Low
positron emission tomography 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hodgkin's Disease 247 100.00 Very High Very High Very High
Lymphatic System Cancer 184 100.00 Very High Very High Very High
Recurrence 6 98.44 Very High Very High Very High
Disease 40 97.52 Very High Very High Very High
Cancer 124 88.80 High High
Arthralgia 2 86.40 High High
Arthritis 25 83.52 Quite High
Pressure And Volume Under Development 5 80.00 Quite High
Pain 14 79.48 Quite High
Severe Combined Immunodeficiency 9 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alternatively, it may be a chance finding or simply indicate that a 25–45 year latency period is typical of pesticide-induced NHL.
Positive_regulation (induced) of NHL associated with hodgkin's disease
1) Confidence 0.17 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247516 Disease Relevance 0.40 Pain Relevance 0
This increase in risk of NHL was more pronounced when exposure started in 1950–1969 than when it first occurred before or after this period.
Positive_regulation (increase) of NHL associated with hodgkin's disease
2) Confidence 0.17 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247516 Disease Relevance 0.29 Pain Relevance 0
For all products combined, there was a linear increase in risk of NHL with increasing cumulative number of uses (p = 0.004).
Positive_regulation (increase) of NHL associated with hodgkin's disease
3) Confidence 0.12 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247516 Disease Relevance 0.29 Pain Relevance 0
When both farming and other types of jobs associated with pesticide exposure were combined, there was a progressive increase in risk of NHL with increasing duration of such work (p = 0.005).
Positive_regulation (increase) of NHL associated with hodgkin's disease
4) Confidence 0.12 Published 2004 Journal Environ Health Perspect Section Abstract Doc Link PMC1247516 Disease Relevance 0.69 Pain Relevance 0
For instance, occupational exposure to pesticides is often accompanied by exposure to other possible hazardous substances, such as solvents, fuels, and dusts (Maroni and Fait 1993; Morrison et al. 1992), that have been associated with increased NHL risk (Mao et al. 2000; Rego 1998).
Positive_regulation (increased) of NHL associated with hodgkin's disease
5) Confidence 0.12 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247516 Disease Relevance 0.38 Pain Relevance 0
After these three courses of R-CHOP, the effect on the NHL was evaluated and disclosed that the intra-abdominal NHL-mass was somewhat reduced, and the remnant of the submandibular lymph node had disappeared.
Positive_regulation (effect) of NHL in submandibular lymph node associated with hodgkin's disease
6) Confidence 0.07 Published 2007 Journal Clin Rheumatol Section Body Doc Link PMC2262146 Disease Relevance 1.12 Pain Relevance 0.41
Although multimodality treatment can induce high rate of remission in many subtypes of non-Hodgkin's lymphoma (NHL), significant proportions of patients relapse with incurable disease.
Positive_regulation (induce) of NHL associated with lymphatic system cancer, disease and recurrence
7) Confidence 0.03 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2886845 Disease Relevance 1.10 Pain Relevance 0
For patients who have received prior ASCT, dose-reduced 131I-TST is a viable option with a chance for response and even long-term control.

131I-TST in the frontline management of B-cell NHL

Positive_regulation (management) of NHL in B-cell associated with lymphatic system cancer
8) Confidence 0.03 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886324 Disease Relevance 0.73 Pain Relevance 0
IL1 haplotype 5 was associated with a statistically significant 43% increased risk for B-NHL among non-regular users of NSAIDs, but a 70% decreased risk for regular users (p-value for interaction < 0.001).
Positive_regulation (increased) of B-NHL
9) Confidence 0.00 Published 2008 Journal Cancer Causes Control Section Body Doc Link 18038187 Disease Relevance 0.12 Pain Relevance 0

General Comments

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