INT148107

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Context Info
Confidence 0.17
First Reported 2006
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 4.56
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (CDIPT) endoplasmic reticulum (CDIPT) plasma membrane (CDIPT)
Anatomy Link Frequency
plasma 1
arms 1
CDIPT (Homo sapiens)
Pain Link Frequency Relevance Heat
Acute pain 2 92.80 High High
opiate 4 91.84 High High
cocaine 2 87.08 High High
carbamazepine 4 86.24 High High
Potency 9 83.16 Quite High
Bioavailability 6 81.60 Quite High
antagonist 9 76.00 Quite High
headache 20 34.72 Quite Low
Pain 12 29.76 Quite Low
Opioid 2 11.20 Low Low
Disease Link Frequency Relevance Heat
Sprains And Strains 23 99.80 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 587 99.66 Very High Very High Very High
Reprotox - General 2 63 99.38 Very High Very High Very High
Hepatitis 10 98.56 Very High Very High Very High
Pancreatitis 4 98.12 Very High Very High Very High
Hyperlipidemia 12 97.24 Very High Very High Very High
Hemorrhage 2 96.92 Very High Very High Very High
Coagulation Disorder 1 96.44 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

6 95.48 Very High Very High Very High
Emergencies 6 95.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Drug-drug interactions with PIs and other coadministered agents for human immunodeficiency virus (HIV) positive population have been discussed in light of efflux transporters and metabolizing enzymes.
PIs Binding (interactions) of associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.17 Published 2006 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18040809 Disease Relevance 0.20 Pain Relevance 0.13
A number of clinical reports on drug interaction between PIs and other classes (macrolide antibiotics, azole antifungals, cholesterol lowering statins, cardiovascular medicines, and immunomodulators) are discussed in this article.
PIs Binding (interaction) of
2) Confidence 0.17 Published 2006 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18040809 Disease Relevance 0.07 Pain Relevance 0.14
Patients at least 16 years of age were enrolled into the studies if they were infected with a CCR5- tropic HIV strain and were receiving at least one NRTI, or one NNRTI, or a fusion inhibitor, two PIs, and had documented resistance to at least three of the aforementioned classes.16 When administered with an optimized background therapy (OBT), more patients in the combined once-daily or twice-daily maraviroc arms achieved an undetectable viral load (<50 copies/mL), than patients receiving placebo (43%, 46%, and 17%, respectively, P < 0.001).16
PIs Binding (receiving) of in arms associated with acquired immune deficiency syndrome or hiv infection and sprains and strains
3) Confidence 0.12 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2952481 Disease Relevance 0.60 Pain Relevance 0.11
Prior cases of antipsychotic-induced priapism have been reported; however, this is the first reported case of priapism associated with a likely drug interaction between antipsychotics and protease inhibitors (PIs).


PIs Spec (likely) Binding (interaction) of associated with reprotox - general 2
4) Confidence 0.08 Published 2010 Journal Int J Emerg Med Section Body Doc Link PMC2885261 Disease Relevance 1.18 Pain Relevance 0.13
In addition, PIs have been associated with serum transaminase elevation, hepatitis, pancreatitis, and spontaneous bleeding in hemophiliacs.
PIs Binding (associated) of associated with coagulation disorder, pancreatitis, hemorrhage and hepatitis
5) Confidence 0.07 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2701488 Disease Relevance 1.11 Pain Relevance 0
Both PIs were significantly less bound in umbilical cord than maternal plasma, indicating that the low cord-mother ratios of total drug were influenced by differential protein binding and the nature of this binding protein (alpha1-acid glycoprotein, human serum albumin).
PIs Binding (bound) of in plasma
6) Confidence 0.07 Published 2009 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2778444 Disease Relevance 0.10 Pain Relevance 0
Quetiapine binds to CYP3A4 and 2D6 as a substrate; the PIs inhibit and also bind to 3A4 and 2D6 creating a larger amount of active quetiapine in the serum.
PIs Binding (bind) of
7) Confidence 0.06 Published 2010 Journal Int J Emerg Med Section Body Doc Link PMC2885261 Disease Relevance 0.36 Pain Relevance 0
Of note, I50L is only selected under ATV pressure and it causes higher susceptibility to other PIs such as amprenavir, darunavir, indinavir, lopinavir (LPV), nelfinavir (NFV) and saquinavir (SQV).6 The prevalence of I50L in large HIV drug resistance mutation databases is generally very low.7
PIs Binding (indinavir) of associated with acquired immune deficiency syndrome or hiv infection
8) Confidence 0.05 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697529 Disease Relevance 0.29 Pain Relevance 0.03
Alternative statins with limited to no clinically significant drug interactions with PIs include Fluvastatin, Pravastatin, and low-dose Atorvastatin.
PIs Neg (no) Binding (interactions) of
9) Confidence 0.03 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682378 Disease Relevance 0.56 Pain Relevance 0

General Comments

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