INT148118

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.78
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2RX1) transport (P2RX1) plasma membrane (P2RX1)
protein complex (P2RX1)
P2RX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 8 99.50 Very High Very High Very High
Pain 8 96.16 Very High Very High Very High
Calcium channel 2 87.12 High High
member 8 2 85.52 High High
Hyperalgesia 1 82.80 Quite High
allodynia 1 81.44 Quite High
Brush evoked pain 1 69.76 Quite High
Inflammation 1 59.04 Quite High
Neuropathic pain 1 57.68 Quite High
Somatostatin 6 48.92 Quite Low
Disease Link Frequency Relevance Heat
Pain 5 96.16 Very High Very High Very High
Injury 1 93.60 High High
Nociception 3 92.16 High High
Hyperalgesia 1 82.80 Quite High
Neuropathic Pain 3 81.44 Quite High
Nervous System Injury 1 67.52 Quite High
INFLAMMATION 1 59.04 Quite High
Shock 4 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P2X1-eGFP receptor fluorescence recovered with a time constant of ?
Positive_regulation (recovered) of Gene_expression (recovered) of P2X1
1) Confidence 0.48 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0
The increase in time constant of recovery of P2X1 FRAP following phorbol ester treatment is consistent with a decrease in the time required for recovery from desensitisation (Ase et al. 2005).
Positive_regulation (recovery) of Gene_expression (recovery) of P2X1 FRAP
2) Confidence 0.48 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0.13
for the equivalent P2X1 receptor region reduced the effects of cholesterol depletion by ?
Positive_regulation (equivalent) of Gene_expression (region) of P2X1 receptor
3) Confidence 0.47 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0
To characterize further the contribution of the amino terminus of the P2X1 receptor to cholesterol sensitivity, two additional chimeras were generated, P2X1-2a?
Positive_regulation (generated) of Gene_expression (generated) of P2X1-2a
4) Confidence 0.47 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0
Evidence from a variety of experimental strategies, including genetic disruption studies and the development of selective antagonists, has indicated that the activation of P2X receptor subtypes, including P2X(3), P2X(2/3), P2X(4) and P2X(7), and P2Y (e.g., P2Y(2)) receptors, can modulate pain.
Positive_regulation (activation) of Gene_expression (subtypes) of P2X receptor associated with pain and antagonist
5) Confidence 0.03 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18042830 Disease Relevance 0.78 Pain Relevance 0.70

General Comments

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