INT148121

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Context Info
Confidence 0.65
First Reported 2004
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 35
Total Number 44
Disease Relevance 29.07
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (KRT8) structural molecule activity (KRT8) nucleus (KRT8)
cytoskeleton organization (KRT8) cytoplasm (KRT8)
Anatomy Link Frequency
epithelial cells 6
lumen 2
liver 1
cleavage 1
oral cavity 1
KRT8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 24 94.36 High High
Inflammation 204 93.36 High High
Pain 5 92.96 High High
aspirin 134 91.88 High High
chemokine 3 89.72 High High
endometriosis 33 76.92 Quite High
Paracetamol 3 71.24 Quite High
agonist 4 47.88 Quite Low
anesthesia 1 10.00 Low Low
medulla 168 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 2199 100.00 Very High Very High Very High
Renal Cancer 193 99.98 Very High Very High Very High
Plasmacytoma 2 99.98 Very High Very High Very High
Malignant Neoplastic Disease 286 99.96 Very High Very High Very High
Mesothelioma 96 99.72 Very High Very High Very High
Breast Cancer 268 99.68 Very High Very High Very High
Carcinoma 534 99.64 Very High Very High Very High
Cleidocranial Dysplasia 146 99.64 Very High Very High Very High
Skin Cancer 696 99.52 Very High Very High Very High
Adamantinoma 80 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AFS: American Fertility Society; CK 7: cytokeratin 7; CK 8/18: cytokeratin 8/18; CD68: cluster of differentiation 68

Competing interests

Gene_expression (/) of CK 8
1) Confidence 0.65 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2789082 Disease Relevance 0.59 Pain Relevance 0.14
It should be noted that K8 and K18 are not strictly epithelium-specific since expression of K8 and K18 may occur in rare mesenchymal cells (more frequently in fetal stages) such as certain smooth muscle cells and fibroblastic reticulum cells of lymph nodes as well as various mesenchymal tumors including rhabdo- and leiomyosarcomas (Huitfeldt and Brandtzaeg 1985; Franke and Moll 1987; van Muijen et al. 1987; Jahn and Franke 1989; Knapp and Franke 1989; Knapp et al. 1989; Jahn et al. 1993; Gould et al. 1995; Kuruc and Franke 1988; Langbein et al. 1989), where they are co-expressed with other intermediate filament types, notably vimentin and desmin.
Gene_expression (expression) of K8 in epithelium associated with leiomyosarcoma and cancer
2) Confidence 0.45 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.18 Pain Relevance 0
While highly specialized parenchymatous epithelial cells in their normal state, such as proximal tubular cells of the kidney, only express K8 and K18, this may change in reactive conditions.
Gene_expression (express) of K8 in epithelial cells
3) Confidence 0.45 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.44 Pain Relevance 0.05
In regard to malignant tumors, K8 and K18 are expressed in most carcinomas except for some differentiated squamous cell carcinomas.
Neg (except) Gene_expression (expressed) of K8 associated with malignant neoplastic disease, carcinoma and skin cancer
4) Confidence 0.45 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.52 Pain Relevance 0.13
Like other adenocarcinomas, most breast carcinomas constitutively express K8, K18 and K19 (Altmannsberger et al. 1986; Malzahn et al. 1998).
Gene_expression (express) of K8 associated with adenocarcinoma and breast cancer
5) Confidence 0.45 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.90 Pain Relevance 0
In a large tissue microarray study, reduced expression of K8 and K20 was found to be associated with shorter patients’ survival, possibly on the basis of epithelial-mesenchymal transition (Knösel et al. 2006).
Gene_expression (expression) of K8
6) Confidence 0.45 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.79 Pain Relevance 0
Thus, conventional (clear cell) RCCs express a simple keratin pattern of mainly K8/K18 together with variable, mostly minor expression of K19.
Gene_expression (express) of K8 associated with renal cancer
7) Confidence 0.40 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.77 Pain Relevance 0
K8, K18, K19, and K7 are expressed in all cell layers.
Gene_expression (expressed) of K8
8) Confidence 0.40 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.03 Pain Relevance 0
Even in non-keratinizing stratified squamous epithelia, K8 and K18 may be focally expressed in the basal cell layer, together with K19 and the constitutive stratified-epithelial keratins (Bosch et al. 1988; Moll 1993).
Gene_expression (expressed) of K8 in basal cell
9) Confidence 0.40 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.11 Pain Relevance 0
Neuroendocrine tumors, a large and heterogeneous tumor group, are generally characterized by the expression of keratins typical of simple epithelia (notably K8, K18, and—more variably—K19) and the complete lack of keratins K5/K14 typically found in stratified epithelia.
Gene_expression (expression) of K8 associated with neuroendocrine cancer and cancer
10) Confidence 0.40 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.49 Pain Relevance 0
At the moment, the panel of keratins introduced into routine diagnosis as histopathological tumor markers is distinctly small, essentially consisting of K5, K7, K8/K18, K19, and K20.
Gene_expression (consisting) of K8 associated with cancer
11) Confidence 0.39 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.66 Pain Relevance 0
Chromophobe RCCs, on the other hand, typically express K7 (but little K19) in addition to K8/K18 (Thoenes et al. 1988).
Gene_expression (express) of K8 associated with renal cancer
12) Confidence 0.39 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.94 Pain Relevance 0
Furthermore, K8/K18 occur—together with other keratins—in various pseudostratified (e.g. respiratory) and complex (e.g. glandular) epithelia and in the urothelium; in these composite epithelial tissues, K8 and K18 are often most prominent in the lumen-lining cells.
Gene_expression (/) of K8 in lumen
13) Confidence 0.39 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0 Pain Relevance 0
Furthermore, K8/K18 occur—together with other keratins—in various pseudostratified (e.g. respiratory) and complex (e.g. glandular) epithelia and in the urothelium; in these composite epithelial tissues, K8 and K18 are often most prominent in the lumen-lining cells.
Gene_expression (occur) of K8 in lumen
14) Confidence 0.39 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0 Pain Relevance 0
In contrast, the papillary subtype of RCC is characterized by strong K19 expression as well as K7 expression in addition to the basic pair K8/K18.
Gene_expression (expression) of K8
15) Confidence 0.39 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.92 Pain Relevance 0
Furthermore, since keratins also exhibit characteristic expression patterns in human tumors, several of them (notably K5, K7, K8/K18, K19, and K20) have great importance in immunohistochemical tumor diagnosis of carcinomas, in particular of unclear metastases and in precise classification and subtyping.
Gene_expression (expression) of K8 associated with cancer, carcinoma and metastasis
16) Confidence 0.39 Published 2008 Journal Histochem Cell Biol Section Abstract Doc Link PMC2386534 Disease Relevance 0.84 Pain Relevance 0
Recently it has been demonstrated that in squamous cell carcinomas of the oral cavity the expression of K8 and K18 is an independent prognostic marker and indicates a decreased overall and progression-free survival (Fillies et al. 2006).
Gene_expression (expression) of K8 in oral cavity associated with skin cancer
17) Confidence 0.35 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.92 Pain Relevance 0
K8/K18: primary keratins of simple epithelial cells
Gene_expression (/) of K8 in epithelial cells
18) Confidence 0.34 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.99 Pain Relevance 0
In contrast to most adenocarcinomas, epithelial mesotheliomas consistently express keratinocyte-type keratins, notably K5, in addition to keratins K8, K18, K19, and K7 typical for simple epithelia (Moll et al. 1989; Ordonez 1998; Chu and Weiss 2002a; Yaziji et al. 2006).
Gene_expression (express) of K8 in keratinocyte associated with adenocarcinoma and mesothelioma
19) Confidence 0.34 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.44 Pain Relevance 0
In some studies, however, a high level of K8 or K18 immunostaining, as detected by certain monoclonal antibodies, has been correlated with favorable prognosis and reduced or absent staining was associated with unfavorable outcome (Takei et al. 1995; Schaller et al. 1996; Woelfle et al. 2004).
Gene_expression (immunostaining) of K8
20) Confidence 0.34 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.92 Pain Relevance 0

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