INT148151

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Context Info
Confidence 0.28
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.40
Pain Relevance 3.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il18) extracellular region (Il18) cytoplasm (Il18)
Anatomy Link Frequency
astrocytes 2
macrophages 1
Plasma 1
dendritic cells 1
skin 1
Il18 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 103 100.00 Very High Very High Very High
antagonist 6 99.16 Very High Very High Very High
Angina 9 99.00 Very High Very High Very High
Neuropathic pain 8 98.80 Very High Very High Very High
allodynia 19 98.28 Very High Very High Very High
Inflammation 160 91.64 High High
Hyperalgesia 154 86.40 High High
substance P 3 77.08 Quite High
reflex sympathetic dystrophy 2 75.00 Quite High
tolerance 12 69.36 Quite High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 6 99.00 Very High Very High Very High
Neuropathic Pain 27 98.80 Very High Very High Very High
Increased Venous Pressure Under Development 5 97.68 Very High Very High Very High
Diabetes Mellitus 25 95.48 Very High Very High Very High
Mucocutaneous Lymph Node Syndrome 2 94.36 High High
INFLAMMATION 197 91.64 High High
Coronary Artery Disease 11 87.60 High High
Hyperalgesia 154 86.40 High High
Nervous System Injury 10 83.52 Quite High
Acute Coronary Syndrome 1 83.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using this model we observed that: (1) inflammasome components and products NALP1, caspase-1, IL-1beta and IL-18 were present in low levels in normal skin, but expression of all these was strongly up-regulated after fracture, (2) NALP1, caspase-1 and IL-1beta were co-expressed in keratinocytes, and the number of NALP1, caspase-1, and IL-1beta positive cells dramatically increased at 4 weeks post-fracture, (3) LY303870, an NK1 receptor antagonist, effectively blocked fracture-induced up-regulation of activated inflammasome components and cytokines, (4) IL-1beta and IL-18 intraplantar injection induced mechanical allodynia in normal rats, and (5) both a selective caspase-1 inhibitor and an IL-1 receptor antagonist attenuated fracture-induced hindpaw mechanical allodynia.
Regulation (regulation) of IL-18 in skin associated with allodynia, antagonist and cytokine
1) Confidence 0.28 Published 2009 Journal Pain Section Abstract Doc Link 19853379 Disease Relevance 0.87 Pain Relevance 0.73
Plasma concentrations of IL-18 and high-sensitivity C-reactive protein (hs-CRP) were measured in 166 consecutive patients admitted for coronary arteriography.
Regulation (concentrations) of IL-18 in Plasma
2) Confidence 0.26 Published 2007 Journal Heart Vessels Section Abstract Doc Link 18043993 Disease Relevance 0.98 Pain Relevance 0.44
Recent studies suggest that IL-18, a member of the IL-1 cytokine family, is released from microglia and acts on the IL-18 receptor on astrocytes [79].
Regulation (acts) of IL-18 in astrocytes associated with cytokine
3) Confidence 0.10 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 1.08 Pain Relevance 0.98
Recent studies suggest that IL-18, a member of the IL-1 cytokine family, is released from microglia and acts on the IL-18 receptor on astrocytes [79].
Regulation (acts) of IL-18 in astrocytes associated with cytokine
4) Confidence 0.10 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 1.09 Pain Relevance 1.00
We found, however, no associations between abnormal glucose regulation and the levels of IL-18, MMP-9, TIMP-1, and adiponectin.
Regulation (regulation) of IL-18
5) Confidence 0.05 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940874 Disease Relevance 1.26 Pain Relevance 0.17
, IL-6, IL-18 [22,23], could be affected in macrophages and dendritic cells by the influence of GCs [12,24].
Regulation (affected) of IL-18 in dendritic cells
6) Confidence 0.04 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0.06 Pain Relevance 0.09
, IL-6, IL-18 [22,23], could be affected in macrophages and dendritic cells by the influence of GCs [12,24].
Regulation (affected) of IL-18 in macrophages
7) Confidence 0.01 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0.06 Pain Relevance 0.09

General Comments

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