INT148152

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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 4.44
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il18) extracellular region (Il18) cytoplasm (Il18)
Anatomy Link Frequency
coronary artery 3
astrocyte 1
microglia 1
Il18 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 4 99.68 Very High Very High Very High
Angina 18 98.12 Very High Very High Very High
Brush evoked pain 6 97.40 Very High Very High Very High
intrathecal 2 93.96 High High
Neuropathic pain 4 85.84 High High
Dorsal horn 2 80.48 Quite High
spinal dorsal horn 2 74.64 Quite High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 30 100.00 Very High Very High Very High
Nervous System Injury 8 98.88 Very High Very High Very High
Increased Venous Pressure Under Development 6 98.60 Very High Very High Very High
Cv General 3 Under Development 18 98.12 Very High Very High Very High
Neuropathic Pain 10 97.40 Very High Very High Very High
Diabetes Mellitus 3 97.04 Very High Very High Very High
Injury 2 87.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the association between IL-18 and the extent of coronary artery atherosclerosis in patients with unstable angina remains unclear.
IL-18 Binding (association) of in coronary artery associated with angina and increased venous pressure under development
1) Confidence 0.46 Published 2007 Journal Heart Vessels Section Abstract Doc Link 18043993 Disease Relevance 0.90 Pain Relevance 0.44
By multiple regression analyses, the association between coronary artery disease severity score and IL-18 remained significant (beta = 0.733, P = 0.017) when controlling for age, diabetes mellitus and left ventricular ejection fraction.
IL-18 Binding (association) of in coronary artery associated with coronary artery disease and diabetes mellitus
2) Confidence 0.46 Published 2007 Journal Heart Vessels Section Abstract Doc Link 18043993 Disease Relevance 1.14 Pain Relevance 0.31
Plasma IL-18 level is associated with the extent of coronary artery disease in unstable angina patients, suggesting the link between IL-18 and coronary artery atherosclerosis in these patients.
IL-18 Binding (associated) of in coronary artery associated with angina, coronary artery disease and increased venous pressure under development
3) Confidence 0.34 Published 2007 Journal Heart Vessels Section Abstract Doc Link 18043993 Disease Relevance 0.89 Pain Relevance 0.17
Our results indicate that IL-18-mediated microglia/astrocyte interactions in the spinal cord have a substantial role in the generation of tactile allodynia.
IL-18 Binding (interactions) of in astrocyte associated with brush evoked pain and spinal cord
4) Confidence 0.19 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 19036970 Disease Relevance 0.75 Pain Relevance 0.63
Our results indicate that IL-18-mediated microglia/astrocyte interactions in the spinal cord have a substantial role in the generation of tactile allodynia.
IL-18 Binding (interactions) of in microglia associated with brush evoked pain and spinal cord
5) Confidence 0.06 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 19036970 Disease Relevance 0.75 Pain Relevance 0.63

General Comments

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