INT148172

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.55
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) transport (Kcnd2) mitochondrion (Mapk1)
protein complex (Mapk1) transmembrane transport (Kcnd2) cytoplasm (Mapk1)
Anatomy Link Frequency
neurons 2
Mapk1 (Mus musculus)
Kcnd2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 3 98.48 Very High Very High Very High
Dorsal horn neuron 4 98.00 Very High Very High Very High
central sensitization 2 96.16 Very High Very High Very High
Neuronal excitability 2 95.12 Very High Very High Very High
Dorsal horn 2 94.24 High High
Glutamate receptor 2 76.60 Quite High
potassium channel 1 34.96 Quite Low
IPN 1 25.00 Low Low
nociceptor 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Injury 1 98.24 Very High Very High Very High
Hypersensitivity 1 97.44 Very High Very High Very High
Nociception 5 81.48 Quite High
Targeted Disruption 1 53.44 Quite High
Inflammatory Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we demonstrate that ERK-mediated phosphorylation of Kv4.2 is downstream of mGlu5 activation in spinal cord dorsal horn neurons.
ERK-mediated Positive_regulation (mediated) of Phosphorylation (phosphorylation) of Kv4.2 in neurons associated with dorsal horn neuron and spinal cord
1) Confidence 0.49 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18045912 Disease Relevance 0.55 Pain Relevance 0.57

General Comments

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