INT148173

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.45
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Grm5, Mapk1) signal transduction (Grm5, Mapk1) nucleoplasm (Mapk1)
mitochondrion (Mapk1) protein complex (Mapk1) signal transducer activity (Grm5)
Anatomy Link Frequency
dorsal horn 3
Grm5 (Mus musculus)
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 1 98.56 Very High Very High Very High
Dorsal horn neuron 4 97.68 Very High Very High Very High
central sensitization 2 88.80 High High
IPN 1 85.12 High High
Neuronal excitability 2 78.36 Quite High
Spinal cord 3 75.00 Quite High
Glutamate receptor 2 75.00 Quite High
Dorsal horn 2 63.96 Quite High
nociceptor 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 1 94.68 High High
Nociception 5 91.32 High High
Injury 1 67.96 Quite High
Hypersensitivity 1 67.16 Quite High
Inflammatory Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Altogether, our results indicate that activation of mGlu5 leads to ERK-mediated phosphorylation and modulation of Kv4.2-containing potassium channels in dorsal horn neurons.
Positive_regulation (activation) of mGlu5 in dorsal horn Positive_regulation (leads) of Phosphorylation (phosphorylation) of ERK-mediated in dorsal horn associated with potassium channel and dorsal horn neuron
1) Confidence 0.01 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18045912 Disease Relevance 0.45 Pain Relevance 0.65

General Comments

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