INT148191

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Context Info
Confidence 0.61
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.22
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Link Frequency
neurons 2
Penk (Mus musculus)
Pain Link Frequency Relevance Heat
Endogenous opioid 3 100.00 Very High Very High Very High
agonist 5 99.98 Very High Very High Very High
Antinociceptive 2 99.78 Very High Very High Very High
Nicotine 14 99.32 Very High Very High Very High
narcan 3 98.68 Very High Very High Very High
Spinal cord 4 97.00 Very High Very High Very High
Hyperalgesia 2 91.56 High High
Inflammation 7 91.04 High High
Enkephalin 3 90.40 High High
Dorsal horn 1 88.44 High High
Disease Link Frequency Relevance Heat
Nociception 4 96.22 Very High Very High Very High
Hyperalgesia 2 91.56 High High
INFLAMMATION 4 91.04 High High
Inflammatory Pain 3 77.64 Quite High
Ganglion Cysts 1 74.44 Quite High
Arthritis 1 69.92 Quite High
Increased Venous Pressure Under Development 1 69.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that nicotine has an antinociceptive effect by promoting the release of Met-ENK, but not dynorphins and endorphins, from activated opioidergic neurons in spinal cord.
Positive_regulation (promoting) of Localization (release) of Met-ENK in neurons associated with nicotine, antinociceptive and spinal cord
1) Confidence 0.61 Published 2008 Journal Brain Res. Section Abstract Doc Link 18048009 Disease Relevance 0.07 Pain Relevance 1.19
The anti-nociceptive effects of PAR(1) agonist were mediated by endogenous opioids, as this effect was inhibited by local injection of naloxone methiodide, and because intraplantar injection of PAR(1) agonist increased mRNA expression of the endogenous opioid precursor proenkephalin.
Positive_regulation (increased) of Localization (expression) of opioid precursor proenkephalin associated with nociception, narcan, endogenous opioid and agonist
2) Confidence 0.05 Published 2009 Journal Pain Section Abstract Doc Link 19674841 Disease Relevance 1.14 Pain Relevance 1.29

General Comments

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