INT148207

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Context Info
Confidence 0.77
First Reported 2003
Last Reported 2010
Negated 2
Speculated 4
Reported most in Body
Documents 53
Total Number 57
Disease Relevance 29.13
Pain Relevance 12.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (CTLA4) plasma membrane (CTLA4)
Anatomy Link Frequency
T cell 17
cytotoxic T lymphocyte 10
regulatory T cells 2
synovial fluid 1
regulatory T-cells 1
CTLA4 (Homo sapiens)
Pain Link Frequency Relevance Heat
abatacept 953 100.00 Very High Very High Very High
cytokine 533 100.00 Very High Very High Very High
chemokine 51 100.00 Very High Very High Very High
rheumatoid arthritis 753 99.84 Very High Very High Very High
spinal inflammation 31 99.56 Very High Very High Very High
Inflammation 611 97.36 Very High Very High Very High
Arthritis 237 96.04 Very High Very High Very High
Inflammatory response 18 95.04 Very High Very High Very High
tolerance 162 94.96 High High
psoriasis 122 94.90 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 762 99.84 Very High Very High Very High
Adhesions 41 99.72 Very High Very High Very High
Low Back Pain 31 99.56 Very High Very High Very High
Leukemia 21 99.52 Very High Very High Very High
Cancer 796 99.10 Very High Very High Very High
Biliary Liver Cirrhosis 246 99.04 Very High Very High Very High
Skin Cancer 375 98.98 Very High Very High Very High
Solid Tumor 17 98.96 Very High Very High Very High
Apoptosis 150 98.74 Very High Very High Very High
Necrosis 65 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies performed during the past 2 years have provided a deeper understanding into the role of CTLA-4, which is expressed on regulatory T cells, in preventing autoimmunity, and also provide mechanistic insight into protein-based therapeutics such as abatacept for rheumatic diseases.
Gene_expression (expressed) of CTLA-4 in regulatory T cells associated with autoimmune disease, abatacept and rheumatic diseases
1) Confidence 0.77 Published 2009 Journal Nat Rev Rheumatol Section Abstract Doc Link 19412189 Disease Relevance 0.34 Pain Relevance 0.09
Endogenous down-regulation of CD28-mediated T cell co-stimulation occurs through T cell expression of cytotoxic T lymphocyte antigen 4 (CTLA-4).
Gene_expression (expression) of CTLA-4 in T cell
2) Confidence 0.75 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2569144 Disease Relevance 0.53 Pain Relevance 0.51
In addressing the potential mechanism of action of abatacept in RA patients, it is of interest to examine whether levels of CD28, CTLA4 and CD80/86 vary among cells in the circulation and in different inflammatory compartments.
Spec (whether) Gene_expression (levels) of CTLA4 associated with inflammation, rheumatoid arthritis and abatacept
3) Confidence 0.64 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833979 Disease Relevance 0.98 Pain Relevance 0.56
Among RA patients more cells with surface expression of CTLA4 were found in synovial fluid than in peripheral blood [50].


Gene_expression (expression) of CTLA4 in synovial fluid associated with rheumatoid arthritis
4) Confidence 0.64 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833979 Disease Relevance 0.59 Pain Relevance 0.36
Significantly less AS patients carried the CTLA-4 high-expressing -318 T allele (P = 0.040).
Gene_expression (expressing) of CTLA-4 associated with spinal inflammation
5) Confidence 0.62 Published 2010 Journal Tissue Antigens Section Abstract Doc Link 20030788 Disease Relevance 0.80 Pain Relevance 0.93
Of these, 62 (2.8%) patients demonstrated an anti-abatacept or anti-CTLA-4 response, determined using either Assay A or B.
Gene_expression (response) of anti-CTLA-4
6) Confidence 0.58 Published 2007 Journal J. Rheumatol. Section Body Doc Link 18050376 Disease Relevance 0.14 Pain Relevance 0
CD28 is constitutively expressed on T-cells, whereas CTLA-4 expression is rapidly upregulated following T-cell activation.
Gene_expression (expression) of CTLA-4 in T-cell
7) Confidence 0.58 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0 Pain Relevance 0
The B7/CD28/CTLA-4 pathway
Gene_expression (pathway) of CTLA-4
8) Confidence 0.58 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0 Pain Relevance 0
CTLA4-Ig ( abatacept) was the first molecule to be developed by fusion of the extra-cellular domain of CTLA4 with the constant region fragment (Fc?)
Gene_expression (domain) of CTLA4 associated with abatacept
9) Confidence 0.57 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998809 Disease Relevance 0.08 Pain Relevance 0.24
CTLA4-Ig ( abatacept) was the first molecule to be developed by fusion of the extra-cellular domain of CTLA4 with the constant region fragment (Fc?)
Gene_expression (domain) of CTLA4-Ig associated with abatacept
10) Confidence 0.57 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998809 Disease Relevance 0.08 Pain Relevance 0.25
Possible effects of CTLA4–Ig on protective immune responses
Gene_expression (effects) of CTLA4
11) Confidence 0.56 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833979 Disease Relevance 0.22 Pain Relevance 0.41
Identical results were obtained for T cell adhesion using either CTLA-4 blocking mAb or CTLA-4Ig (abatacept), indicating CTLA-4 as the T cell ligand for these CD86-mediated effects.
Neg (blocking) Gene_expression (blocking) of CTLA-4Ig in T cell associated with abatacept and adhesions
12) Confidence 0.56 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18941200 Disease Relevance 0.53 Pain Relevance 0.16
Identical results were obtained for T cell adhesion using either CTLA-4 blocking mAb or CTLA-4Ig (abatacept), indicating CTLA-4 as the T cell ligand for these CD86-mediated effects.
Neg (blocking) Gene_expression (blocking) of CTLA-4 in T cell associated with abatacept and adhesions
13) Confidence 0.56 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18941200 Disease Relevance 0.53 Pain Relevance 0.16
A CTLA4-Ig fusion protein was initially applied in rodent models of transplantation [14], in which graft survival was prolonged.
Gene_expression (applied) of CTLA4-Ig
14) Confidence 0.54 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582812 Disease Relevance 0.86 Pain Relevance 0.28
Two patients produced antibodies against the CTLA4-T portion (not the whole molecule), which were transient in one and there was no follow up in the second.
Gene_expression (produced) of CTLA4
15) Confidence 0.54 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582812 Disease Relevance 0.36 Pain Relevance 0.60
This review concentrates on the outcomes of CTLA4-directed therapies in RA.


Gene_expression (therapies) of CTLA4-directed associated with rheumatoid arthritis
16) Confidence 0.54 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582812 Disease Relevance 0.19 Pain Relevance 0.19
CTLA4 is a homolog to CD28 and is expressed by activated T cells.
Gene_expression (expressed) of CTLA4 in T cells
17) Confidence 0.54 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.85 Pain Relevance 0.27
Apart from their constitutive expression of CD25, Treg cells are characterized phenotypically by surface expression of CTLA4 [66] and glucocorticoid induced TNF receptor family related protein [67], as well as by the expression of the transcription factor Foxp3 [68].
Gene_expression (expression) of CTLA4
18) Confidence 0.54 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.34 Pain Relevance 0.08
This study investigated the genotypic distribution of proinflammatory cytokines and T-cell negative regulator cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) in healthy subjects and AS patients.
Spec (investigated) Gene_expression (distribution) of CTLA-4 in cytotoxic T lymphocyte associated with spinal inflammation and cytokine
19) Confidence 0.54 Published 2010 Journal Tissue Antigens Section Abstract Doc Link 20030788 Disease Relevance 0.67 Pain Relevance 0.73
B7/CTLA-4 interactions and regulatory T-cells
Gene_expression (/) of CTLA-4 in regulatory T-cells
20) Confidence 0.51 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0.06 Pain Relevance 0.18

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