INT148212

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 5.47
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (C3) extracellular space (C3) extracellular region (C3)
Anatomy Link Frequency
nerve 2
lungs 2
C3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Thermal hyperalgesia 3 95.96 Very High Very High Very High
allodynia 3 94.52 High High
Sciatic nerve 2 84.64 Quite High
Inflammation 5 80.24 Quite High
Neuropathic pain 6 78.16 Quite High
Peripheral nerve injury 2 75.20 Quite High
Pain 1 56.52 Quite High
neuralgia 2 25.00 Low Low
Hyperesthesia 1 25.00 Low Low
anesthesia 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 15 99.92 Very High Very High Very High
Cirrhosis 291 99.20 Very High Very High Very High
Sprains And Strains 93 96.64 Very High Very High Very High
Hyperalgesia 3 95.96 Very High Very High Very High
Bacterial Meningitis 129 95.92 Very High Very High Very High
Neuropathic Pain 9 94.52 High High
Infection 51 93.48 High High
Hepatotoxicity 3 86.08 High High
INFLAMMATION 5 80.24 Quite High
Pneumococcal Infection 42 77.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Complement inhibition using systemic injections of soluble complement receptor 1 (AVANT Immunotherapeutics, Inc., Needham, USA) into rats markedly suppressed C3 deposition and T-cell and macrophage recruitment to the injured nerve, and produced significant alleviation of thermal hyperalgesia and mechanical allodynia.
Negative_regulation (suppressed) of Gene_expression (deposition) of C3 in nerve associated with allodynia and thermal hyperalgesia
1) Confidence 0.43 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 18052971 Disease Relevance 1.19 Pain Relevance 1.21
Levels of lysozyme and complement component C3 were both significantly reduced in bronchoalveolar lavage fluid from cirrhotic rats.
Negative_regulation (reduced) of Gene_expression (Levels) of complement component C3 associated with cirrhosis
2) Confidence 0.24 Published 2007 Journal BMC Microbiol Section Abstract Doc Link PMC2140065 Disease Relevance 1.67 Pain Relevance 0
This argument was strengthened by the present study demonstrating both significantly decreased levels of complement component C3 in the alveolar lining fluid of cirrhotic rats and decreased complement deposition on the surface of pneumococci recovered from their lungs after a transtracheal infection.
Negative_regulation (decreased) of Gene_expression (levels) of complement component C3 in lungs associated with bacterial meningitis, cirrhosis and infection
3) Confidence 0.24 Published 2007 Journal BMC Microbiol Section Body Doc Link PMC2140065 Disease Relevance 1.32 Pain Relevance 0
Our laboratory and others have shown that cirrhotic hosts are often hypocomplementemic, with decreased levels of complement component C3 in their serum and ascites fluid [13,46,47].
Negative_regulation (decreased) of Gene_expression (levels) of complement component C3 associated with pressure and volume under development and cirrhosis
4) Confidence 0.24 Published 2007 Journal BMC Microbiol Section Body Doc Link PMC2140065 Disease Relevance 1.29 Pain Relevance 0.03

General Comments

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