INT14822

Context Info Confidence 0.49 First Reported 1985 Last Reported 1991 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 1.35 Pain Relevance 1.94

cell proliferation (MET) signal transduction (MET) plasma membrane (MET)

Anatomy Link Frequency lamina 4 MET (Homo sapiens)

Pain Link Frequency Relevance Heat Enkephalin 9 100.00 opiate 4 100.00 substance P 4 100.00 Opioid 4 100.00 Immobilon 2 93.36 MU agonist 1 72.00 Neurotransmitter 2 53.28

Disease Link Frequency Relevance Heat Hyperplasia 10 94.88 Megacolon 2 79.60 Adenoma 2 79.00 Adenocarcinoma 2 77.56 Disease 2 76.92 Multiple Endocrine Neoplasia 2 70.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Increased reactivity for vasoactive intestinal polypeptide, opioid peptides leu-enkephalin and met-enkephalin, and substance P was present in all cases with transmural involvement; mucosal GN showed normal reactivity for opioid peptides and focal increased staining for substance P (one case) and vasoactive intestinal polypeptide (two cases) in the lamina propria.

Positive_regulation (present) of met Binding (reactivity) of in lamina associated with enkephalin, opioid and substance p

1) Confidence 0.49 Published 1991 Journal Hum. Pathol. Section Abstract Doc Link 1706307 Disease Relevance 0.68 Pain Relevance 0.52

Increased reactivity for vasoactive intestinal polypeptide, opioid peptides leu-enkephalin and met-enkephalin, and substance P was present in all cases with transmural involvement; mucosal GN showed normal reactivity for opioid peptides and focal increased staining for substance P (one case) and vasoactive intestinal polypeptide (two cases) in the lamina propria.

Positive_regulation (Increased) of met Binding (reactivity) of in lamina associated with enkephalin, opioid and substance p

2) Confidence 0.49 Published 1991 Journal Hum. Pathol. Section Abstract Doc Link 1706307 Disease Relevance 0.68 Pain Relevance 0.52

On the other hand, Kd values for 3H-Met-enkephalin and 3H-DHM (mu-opiate receptors) specific binding are enhanced.

Positive_regulation (enhanced) of Met Binding (binding) of associated with opiate and enkephalin

3) Confidence 0.45 Published 1985 Journal Alcohol Section Abstract Doc Link 2990502 Disease Relevance 0 Pain Relevance 0.90

General Comments

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