INT14822

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Context Info
Confidence 0.49
First Reported 1985
Last Reported 1991
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.35
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (MET) signal transduction (MET) plasma membrane (MET)
Anatomy Link Frequency
lamina 4
MET (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 9 100.00 Very High Very High Very High
opiate 4 100.00 Very High Very High Very High
substance P 4 100.00 Very High Very High Very High
Opioid 4 100.00 Very High Very High Very High
Immobilon 2 93.36 High High
MU agonist 1 72.00 Quite High
Neurotransmitter 2 53.28 Quite High
Disease Link Frequency Relevance Heat
Hyperplasia 10 94.88 High High
Megacolon 2 79.60 Quite High
Adenoma 2 79.00 Quite High
Adenocarcinoma 2 77.56 Quite High
Disease 2 76.92 Quite High
Multiple Endocrine Neoplasia 2 70.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased reactivity for vasoactive intestinal polypeptide, opioid peptides leu-enkephalin and met-enkephalin, and substance P was present in all cases with transmural involvement; mucosal GN showed normal reactivity for opioid peptides and focal increased staining for substance P (one case) and vasoactive intestinal polypeptide (two cases) in the lamina propria.
Positive_regulation (present) of met Binding (reactivity) of in lamina associated with enkephalin, opioid and substance p
1) Confidence 0.49 Published 1991 Journal Hum. Pathol. Section Abstract Doc Link 1706307 Disease Relevance 0.68 Pain Relevance 0.52
Increased reactivity for vasoactive intestinal polypeptide, opioid peptides leu-enkephalin and met-enkephalin, and substance P was present in all cases with transmural involvement; mucosal GN showed normal reactivity for opioid peptides and focal increased staining for substance P (one case) and vasoactive intestinal polypeptide (two cases) in the lamina propria.
Positive_regulation (Increased) of met Binding (reactivity) of in lamina associated with enkephalin, opioid and substance p
2) Confidence 0.49 Published 1991 Journal Hum. Pathol. Section Abstract Doc Link 1706307 Disease Relevance 0.68 Pain Relevance 0.52
On the other hand, Kd values for 3H-Met-enkephalin and 3H-DHM (mu-opiate receptors) specific binding are enhanced.
Positive_regulation (enhanced) of Met Binding (binding) of associated with opiate and enkephalin
3) Confidence 0.45 Published 1985 Journal Alcohol Section Abstract Doc Link 2990502 Disease Relevance 0 Pain Relevance 0.90

General Comments

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