INT14823

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Context Info
Confidence 0.75
First Reported 1983
Last Reported 2010
Negated 4
Speculated 4
Reported most in Abstract
Documents 103
Total Number 107
Disease Relevance 51.92
Pain Relevance 32.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (MET) signal transduction (MET) plasma membrane (MET)
Anatomy Link Frequency
hepatocyte 5
HGF 4
blood 3
CSF 2
brain 2
MET (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 124 100.00 Very High Very High Very High
substance P 26 100.00 Very High Very High Very High
narcan 24 100.00 Very High Very High Very High
opiate 11 100.00 Very High Very High Very High
adenocard 7 100.00 Very High Very High Very High
Somatostatin 6 100.00 Very High Very High Very High
Cholecystokinin 5 100.00 Very High Very High Very High
Pain 844 99.98 Very High Very High Very High
Catecholamine 20 99.96 Very High Very High Very High
Opioid 199 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 1862 100.00 Very High Very High Very High
Pain 1010 99.98 Very High Very High Very High
Stomach Cancer 49 99.96 Very High Very High Very High
Hepatocellular Cancer 232 99.88 Very High Very High Very High
Chronic Hepatitis 99 99.84 Very High Very High Very High
Aging 10 99.76 Very High Very High Very High
Carcinoma 151 99.72 Very High Very High Very High
Low Back Pain 48 99.66 Very High Very High Very High
Cholangiocarcinoma 740 99.48 Very High Very High Very High
Adhesions 15 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The organization of the cholinergic fiber system was compared with that of striatal systems expressing immunoreactivity for calbindin D28k, met-enkephalin, substance P, tyrosine hydroxylase, and parvalbumin.
Gene_expression (expressing) of met associated with enkephalin and substance p
1) Confidence 0.75 Published 1997 Journal J. Comp. Neurol. Section Abstract Doc Link 9214537 Disease Relevance 0 Pain Relevance 0.31
The levels of leu-enkephalin (LENK) and met-enkephalin (MENK) were examined in 4.5 ml of cerebrospinal fluid (CSF).
Spec (examined) Gene_expression (levels) of met in CSF associated with enkephalin
2) Confidence 0.75 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9574842 Disease Relevance 0.30 Pain Relevance 0.81
These findings suggest that Met-enk and Leu-enk are locally produced by synovial tissues and may exert an immunological and/or inflammatory role in RA synovitis.
Gene_expression (produced) of Met associated with inflammation, synovitis and rheumatoid arthritis
3) Confidence 0.75 Published 1993 Journal Arerugi Section Abstract Doc Link 8498896 Disease Relevance 0.71 Pain Relevance 0.61
As a result of immunohistological standing (ABC method), Met-enk was detected in vascular endothelial cells and Leu-enk in superficial cells, vascular endothelial cells and interstitial cells.
Gene_expression (detected) of Met in endothelial cells
4) Confidence 0.75 Published 1993 Journal Arerugi Section Abstract Doc Link 8498896 Disease Relevance 0.64 Pain Relevance 0.71
The novel "prohormone thiol protease" (PTP) has been proposed as a candidate proenkephalin processing enzyme for the production of [Met]enkephalin in chromaffin granules (Krieger, T.
Gene_expression (production) of Met associated with enkephalin
5) Confidence 0.75 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7768928 Disease Relevance 0 Pain Relevance 0.46
This response occurred only if a functional, properly processed c-Met receptor was present, which was then rapidly phosphorylated.
Gene_expression (present) of c-Met
6) Confidence 0.75 Published 2005 Journal Cancer Res. Section Abstract Doc Link 16267016 Disease Relevance 0.70 Pain Relevance 0.26
Sequential stainings or staining comparison of contiguous semi-thin sections failed to prove the coexpression of corticoliberin and [Met]enkephalin immunoreactivities in fibres, but indicated that corticoliberin and vasopressin immunoreactivities may be coexpressed in a few fibres.
Gene_expression (coexpression) of Met associated with enkephalin
7) Confidence 0.75 Published 1985 Journal Neuroscience Section Abstract Doc Link 3873629 Disease Relevance 0 Pain Relevance 0.19
Overexpression of HGF/c-Met has been described in different tumors such as breast cancer [128] as well as head and neck cancer [129], also in endometrial carcinoma [130].
Gene_expression (Overexpression) of c-Met in head associated with cancer, breast cancer, endometrial cancer and head & neck cancer
8) Confidence 0.75 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.29 Pain Relevance 0.03
Radioimmunoassays that measure beta-endorphin (BE) and met-enkephalin (MET) having recently become available, we decided to evaluate the possible relation between the blood levels of these two opioids and different hypercapnic and hypoxic ventilatory responses observed in a group of normal subjects.
Gene_expression (measure) of MET in blood associated with hypoxia, enkephalin and opioid
9) Confidence 0.65 Published 1985 Journal Respir Physiol Section Abstract Doc Link 2930889 Disease Relevance 0.51 Pain Relevance 0.59
Measurement of catecholamines, met-enkephalin, somatostatin and substance P-like immunoreactivities in 12 human pheochromocytomas.
Gene_expression (immunoreactivities) of met associated with catecholamine, neuropeptide, somatostatin, enkephalin, pheochromocytoma and substance p
10) Confidence 0.65 Published 1988 Journal J. Endocrinol. Invest. Section Title Doc Link 2452181 Disease Relevance 0.63 Pain Relevance 1.35
The distribution of immunoreactive cholecystokinin, substance P, [Met]enkephalin, [Leu]-enkephalin and dynorphin was determined in the cerebral cortex of the human brain post mortem.
Spec (determined) Gene_expression (distribution) of Met in brain associated with dynorphin, enkephalin, cerebral cortex, cholecystokinin and substance p
11) Confidence 0.65 Published 1988 Journal Neuroscience Section Abstract Doc Link 2472575 Disease Relevance 0 Pain Relevance 0.73
In this study, Met-enkephalin (Met-enk), substance P (SP) and tyrosine hydroxylase (TH) immunostaining was assessed in caudate nucleus biopsies from 15 Parkinson's disease patients who were treated surgically.
Gene_expression (assessed) of Met in caudate nucleus associated with enkephalin, disease and substance p
12) Confidence 0.65 Published 1999 Journal Peptides Section Abstract Doc Link 10422881 Disease Relevance 0.26 Pain Relevance 0.35
In PMNLs obtained from healthy aged male subjects, Met-enk induced in all of the applied concentrations an increased cAMP level and no change in cGMP level, with subsequent decrease of cytotoxicity, i.e. an impaired negative coupling of naloxone sensitive opiate receptors was detected with aging.
Gene_expression (detected) of Met associated with aging, narcan and opiate
13) Confidence 0.65 Published 1987 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 2826349 Disease Relevance 0.10 Pain Relevance 0.43
In the proenkephalin sequence of S. multiplicatus the penultimate opioid is a Met-enkephalin sequence rather than the Leu-enkephalin present in mammalian sequences.
Gene_expression (present) of Met associated with enkephalin and opioid
14) Confidence 0.65 Published 2000 Journal Peptides Section Abstract Doc Link 10793214 Disease Relevance 0 Pain Relevance 0.99
Synthetic (1-39)ACTH, (1-24)ACTH, (18-39)ACTH, alpha-MSH, met-enkephalin and alpha-, beta- and gamma-endorphin were tested for their ability to stimulate steroidogenesis by human fetal adrenal cells in culture.
Gene_expression (Synthetic) of met associated with enkephalin
15) Confidence 0.65 Published 1983 Journal J. Endocrinol. Section Abstract Doc Link 6306129 Disease Relevance 0 Pain Relevance 0.10
Naloxone inhibited the augmentation of NK activity produced by beta-endorphin and met-enkephalin.
Gene_expression (produced) of met associated with narcan and enkephalin
16) Confidence 0.65 Published 1983 Journal J. Immunol. Section Abstract Doc Link 6300232 Disease Relevance 0 Pain Relevance 0.66
Close vicinity of corticoliberin, vasopressin and [Met]enkephalin fibres, in some eminential areas and coexpression of corticoliberin and vasopressin immunoreactivities in some neurons, are morphological correlates of functional relations which were reported.
Gene_expression (fibres) of Met in neurons associated with enkephalin
17) Confidence 0.65 Published 1985 Journal Neuroscience Section Abstract Doc Link 3873629 Disease Relevance 0 Pain Relevance 0.22
Radioimmunoassays that measure beta-endorphin (BE) and met-enkephalin (MET) having recently become available, we decided to evaluate the possible relation between the blood levels of these two opioids and different hypercapnic and hypoxic ventilatory responses observed in a group of normal subjects.
Gene_expression (measure) of met in blood associated with hypoxia, enkephalin and opioid
18) Confidence 0.65 Published 1985 Journal Respir Physiol Section Abstract Doc Link 2930889 Disease Relevance 0.50 Pain Relevance 0.58
A further increase in enzyme activity was found when Met-Enk (10(-4) or 10(-7) M) was added simultaneously with peptidase inhibitors.
Gene_expression (added) of Met
19) Confidence 0.65 Published 1985 Journal Neurosci. Lett. Section Abstract Doc Link 2997669 Disease Relevance 0 Pain Relevance 0.95
Four types of the elongated Met-enkephalins we identified by searching protein databases, (Xl)YGGFMRGY (three frog species and platypus), (Gg)YGGFMRSV (chicken and one fish species), (Hp)YGGFMNGF (shark) and (Mm)YGGFMRSL (mouse and two lungfish species) were chemically synthesized and studied in receptor binding and G-protein activation assays performed on rat brain membranes.
Gene_expression (synthesized) of Met in brain associated with enkephalin
20) Confidence 0.65 Published 2010 Journal Neuroscience Section Abstract Doc Link 19819305 Disease Relevance 0 Pain Relevance 0.55

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