INT148237

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.05
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tbpl1) DNA binding (Tbpl1) cytoplasm (Tbpl1)
Anatomy Link Frequency
tear 1
brain stem 1
Tbpl1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 19 100.00 Very High Very High Very High
c fibre 1 100.00 Very High Very High Very High
Thermal hyperalgesia 2 99.98 Very High Very High Very High
Pain 2 96.16 Very High Very High Very High
nociceptor 4 90.64 High High
imagery 2 89.16 High High
hypoalgesia 1 85.80 High High
long-term potentiation 14 79.12 Quite High
antagonist 3 77.36 Quite High
Hippocampus 21 69.52 Quite High
Disease Link Frequency Relevance Heat
Depression 18 100.00 Very High Very High Very High
Hyperalgesia 2 99.98 Very High Very High Very High
Cough 1 97.40 Very High Very High Very High
Respiratory Failure 1 97.12 Very High Very High Very High
Pain 2 96.16 Very High Very High Very High
Hypersensitivity 1 93.20 High High
Hypoalagesia 1 85.80 High High
Nociception 3 83.32 Quite High
Fatigue 24 76.56 Quite High
INFLAMMATION 2 67.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SCF-induced thermal hyperalgesia required the TRP family cation channel TRPV1.
Positive_regulation (required) of TRP associated with thermal hyperalgesia
1) Confidence 0.49 Published 2007 Journal Neuron Section Abstract Doc Link 18054864 Disease Relevance 0.45 Pain Relevance 0.37
TRPA1, a TRP ion channel expressed in chemosensory C-fibers, is activated by almost all oxidizing and electrophilic chemicals, including chlorine, acrolein, tear gas agents, and methyl isocyanate, the highly noxious chemical released in the Bhopal disaster.
Positive_regulation (activated) of TRP in tear associated with c fibre
2) Confidence 0.45 Published 2010 Journal Proc Am Thorac Soc Section Abstract Doc Link 20601631 Disease Relevance 0.64 Pain Relevance 0.46
In addition, Leathwood and Fernstrom [41] suggested that a 13- to 26- fold elevation in total Trp:LNAA ratio is required to induce a change in the brain stem [5-HT] in monkeys.
Positive_regulation (elevation) of Trp in brain stem
3) Confidence 0.25 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2570654 Disease Relevance 0.14 Pain Relevance 0.17
We found that STD was significantly enhanced in slices of EPO mice compared to control (Figure 3j, k).
Positive_regulation (enhanced) of STD associated with depression
4) Confidence 0.11 Published 2008 Journal BMC Biol Section Body Doc Link PMC2562991 Disease Relevance 0.81 Pain Relevance 0.58

General Comments

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