INT148260

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.68
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR4A2) signal transduction (NR4A2) nucleus (NR4A2)
cytoplasm (NR4A2)
Anatomy Link Frequency
spinal 1
NR4A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
midbrain 7 100.00 Very High Very High Very High
Opioid 2 99.38 Very High Very High Very High
Dopamine 16 99.16 Very High Very High Very High
Ventral tegmentum 4 74.20 Quite High
Spinal cord 6 72.24 Quite High
Nucleus accumbens 1 67.72 Quite High
Kappa opioid receptor 1 45.08 Quite Low
opiate 1 30.00 Quite Low
gABA 8 22.68 Low Low
Central nervous system 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 1 99.66 Very High Very High Very High
Rheumatoid Arthritis 21 99.00 Very High Very High Very High
Opiate Addiction 4 98.18 Very High Very High Very High
Disease 4 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Frailty 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Heroin abuse is characterized by discrete mesolimbic dopamine and opioid abnormalities and exaggerated nuclear receptor-related 1 transcriptional decline with age.
Negative_regulation (decline) of nuclear receptor-related 1 associated with dopamine, congenital anomalies, opiate addiction and opioid
1) Confidence 0.36 Published 2007 Journal J. Neurosci. Section Title Doc Link 18057194 Disease Relevance 0.33 Pain Relevance 0.44
The neural progenitors acquired a spinal positional identity because the RA treatment completely suppressed or significantly downregulated the rostral markers RX, BF1, GBX2 as well as midbrain dopaminergic markers PTX3, PAX2, NURR1, LMX1B, and TH (Figures 4E and 4F).
Negative_regulation (downregulated) of NURR1 in spinal associated with rheumatoid arthritis and midbrain
2) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0.35 Pain Relevance 0.12

General Comments

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