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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.31
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR4A2) signal transduction (NR4A2) nucleus (NR4A2)
cytoplasm (NR4A2)
Anatomy Link Frequency
midbrain 2
NR4A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 1 99.76 Very High Very High Very High
Opioid 2 99.08 Very High Very High Very High
Dopamine 7 98.86 Very High Very High Very High
midbrain 2 98.00 Very High Very High Very High
Ventral tegmentum 4 92.40 High High
Kappa opioid receptor 1 87.16 High High
Nucleus accumbens 1 64.32 Quite High
Disease Link Frequency Relevance Heat
Opiate Addiction 4 83.72 Quite High
Congenital Anomalies 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Altogether the current findings provide direct neurobiological evidence that midbrain reward circuits have the most prominent DA and opioid impairments in human heroin abusers and that abnormal Nurr1 transcription with opiate use may exacerbate limbic dysfunction with age.
Negative_regulation (abnormal) of Transcription (transcription) of Nurr1 in midbrain associated with dopamine, opiate, midbrain and opioid
1) Confidence 0.41 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18057194 Disease Relevance 0.31 Pain Relevance 0.72

General Comments

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