INT148266

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.17
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SNCA) oxidoreductase activity (SNCA) cell death (SNCA)
extracellular region (SNCA) histone binding (SNCA) plasma membrane (SNCA)
Anatomy Link Frequency
substantia nigra 1
spinal cord 1
striatum 1
brain stem 1
SNCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Ventral tegmentum 4 99.68 Very High Very High Very High
Substantia nigra 173 99.30 Very High Very High Very High
Spinal cord 2 99.00 Very High Very High Very High
Dopamine 87 98.38 Very High Very High Very High
midbrain 5 93.84 High High
Kappa opioid receptor 1 92.48 High High
Nucleus accumbens 1 84.00 Quite High
Opioid 2 75.00 Quite High
depression 3 68.80 Quite High
Pain 6 67.84 Quite High
Disease Link Frequency Relevance Heat
Parkinson's Disease 31 99.52 Very High Very High Very High
Opiate Addiction 4 99.28 Very High Very High Very High
Disease 183 97.90 Very High Very High Very High
Cytomegalovirus Infection 9 85.76 High High
Genetic Predisposition To Disease 2 81.84 Quite High
Paralysis 1 75.04 Quite High
Congenital Anomalies 4 75.00 Quite High
Epilepsy 3 71.36 Quite High
Depression 3 68.80 Quite High
Pain 4 67.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was reduced to 1.6-fold in the post-levodopa era with a trend to increase again.14,15 The pathologic hallmark of PD is the loss of dopamine producing neurons in the substantia nigra (SN) accompanied by the intraneuronal accumulation of alpha-synuclein containing Lewy bodies (LB) resulting in dopamine deficiency.16,17 There is much research on the etiology and pathogenesis of PD.
Positive_regulation (accumulation) of alpha-synuclein in substantia nigra associated with parkinson's disease, dopamine, substantia nigra and disease
1) Confidence 0.67 Published 2010 Journal Core Evidence Section Body Doc Link PMC2915499 Disease Relevance 1.07 Pain Relevance 0.23
It is characterised by the presence of severe pars-compacta nigral-cell loss, and accumulation of aggregated alpha-synuclein in specific brain stem, spinal cord, and cortical regions.
Positive_regulation (accumulation) of alpha-synuclein in spinal cord associated with spinal cord
2) Confidence 0.45 Published 2009 Journal Lancet Section Abstract Doc Link 19524782 Disease Relevance 0.45 Pain Relevance 0.19
Transport of viral vector mediated GFP or alpha-synuclein along the nigrostriatal projection was indicated by expression in terminals throughout the striatum.
Positive_regulation (mediated) of alpha-synuclein in striatum
3) Confidence 0.42 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2984491 Disease Relevance 0.08 Pain Relevance 0.34
Three vectors were produced using this design, in the first, the gene for mutated human alpha-synuclein was inserted, this vector is termed AAV1/2-A53T ?
Positive_regulation (mutated) of alpha-synuclein
4) Confidence 0.42 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2984491 Disease Relevance 0.34 Pain Relevance 0
Three vectors were produced using this design, in the first, the gene for mutated human alpha-synuclein was inserted, this vector is termed AAV1/2-A53T ?
Positive_regulation (inserted) of alpha-synuclein
5) Confidence 0.42 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2984491 Disease Relevance 0.35 Pain Relevance 0
TH and alpha-synuclein mRNA levels were, in contrast, elevated in the VTA PN in heroin users with no change of the D2 receptor.
Positive_regulation (elevated) of alpha-synuclein mRNA associated with ventral tegmentum and opiate addiction
6) Confidence 0.40 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18057194 Disease Relevance 0.42 Pain Relevance 0.78
It is characterised by the presence of severe pars-compacta nigral-cell loss, and accumulation of aggregated alpha-synuclein in specific brain stem, spinal cord, and cortical regions.
Positive_regulation (accumulation) of alpha-synuclein in brain stem associated with spinal cord
7) Confidence 0.15 Published 2009 Journal Lancet Section Abstract Doc Link 19524782 Disease Relevance 0.45 Pain Relevance 0.19

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