INT148298

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.36
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcna7) transmembrane transport (Kcna7)
Kcna7 (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 2 83.92 Quite High
Analgesic 3 80.96 Quite High
anticonvulsant 1 75.92 Quite High
hyperexcitability 5 63.52 Quite High
diclofenac 28 54.68 Quite High
Action potential 3 45.36 Quite Low
dorsal root ganglion 18 43.68 Quite Low
cINOD 19 5.00 Very Low Very Low Very Low
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 11 99.66 Very High Very High Very High
Epilepsy 4 98.46 Very High Very High Very High
Deafness 1 96.20 Very High Very High Very High
Disease 5 66.32 Quite High
Ganglion Cysts 18 43.68 Quite Low
Colon Cancer 7 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Syndrome 4 5.00 Very Low Very Low Very Low
Lewis Lung Carcinoma 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutations in Kv7.2 and/or Kv7.3 genes are responsible for an autosomal-dominant epilepsy of the newborn defined as benign familial neonatal seizures (BFNS), whereas defects in the Kv7.4 gene have been found in families affected by a rare form of nonsyndromic autosomal-dominant hearing loss (DFNA2).
Negative_regulation (defects) of Kv7 associated with epilepsy, deafness and convulsion
1) Confidence 0.05 Published 2008 Journal Curr Opin Pharmacol Section Abstract Doc Link 18061539 Disease Relevance 0.36 Pain Relevance 0.19
Except for a moderate inhibition of Kv1.2 and Kv7.1 currents (34% and 23 %, respectively), compound 6 (50 ┬ÁM) did not affect the current amplitude of Kv11.1 (hERG), Kv2.1 and Kv4.3.
Negative_regulation (inhibition) of Kv7
2) Confidence 0.00 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2131780 Disease Relevance 0 Pain Relevance 0.03

General Comments

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