INT148299

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.37
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNQ4) transmembrane transport (KCNQ4) cytoplasm (KCNQ4)
KCNQ4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Analgesic 1 90.08 High High
anticonvulsant 3 85.04 High High
potassium channel 7 79.08 Quite High
hyperexcitability 1 72.64 Quite High
Spinal cord 8 69.72 Quite High
addiction 2 49.08 Quite Low
Action potential 24 41.08 Quite Low
medulla 2 21.16 Low Low
sodium channel 18 11.28 Low Low
unmyelinated 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Deafness 1 100.00 Very High Very High Very High
Convulsion 1 97.24 Very High Very High Very High
Epilepsy 8 96.04 Very High Very High Very High
Disease 2 75.44 Quite High
Helminth Infection 8 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low
Ataxia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutations in Kv7.2 and/or Kv7.3 genes are responsible for an autosomal-dominant epilepsy of the newborn defined as benign familial neonatal seizures (BFNS), whereas defects in the Kv7.4 gene have been found in families affected by a rare form of nonsyndromic autosomal-dominant hearing loss (DFNA2).
Negative_regulation (loss) of DFNA2 associated with epilepsy, deafness and convulsion
1) Confidence 0.11 Published 2008 Journal Curr Opin Pharmacol Section Abstract Doc Link 18061539 Disease Relevance 0.37 Pain Relevance 0.21
Therefore, these motifs either evolved in an earlier KCNQ common ancestor gene, but were lost subsequently by evolution of KCNQ1, KCNQ4 and KCNQ5, or appeared first in a gene ancestral only to KCNQ2 and KCNQ3.
Negative_regulation (evolution) of KCNQ4
2) Confidence 0.09 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2597720 Disease Relevance 0 Pain Relevance 0.03
Phylogenetic analysis revealed these cloned cDNAs (GenBank FJ461777 and FJ461776) to be likely orthologues of KCNQ4 and KCNQ5 (Figure 2C, Supplementary Figure 6).
Spec (likely) Negative_regulation (orthologues) of KCNQ4
3) Confidence 0.09 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2597720 Disease Relevance 0 Pain Relevance 0

General Comments

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