INT148301

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 23
Total Number 30
Disease Relevance 14.24
Pain Relevance 13.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2ry12) plasma membrane (P2ry12) signal transducer activity (P2ry12)
Anatomy Link Frequency
microglial cells 9
megakaryoblasts 2
Platelet 2
neurons 2
macrophage 1
P2ry12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cannabinoid 16 100.00 Very High Very High Very High
Central nervous system 234 99.96 Very High Very High Very High
medulla 109 99.90 Very High Very High Very High
Inflammation 457 99.68 Very High Very High Very High
Nicotine 2 99.66 Very High Very High Very High
Neuropathic pain 125 99.42 Very High Very High Very High
trigeminal ganglion 312 99.28 Very High Very High Very High
Hyperalgesia 36 98.24 Very High Very High Very High
Pain 153 97.84 Very High Very High Very High
midbrain 3 97.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 505 99.68 Very High Very High Very High
Nicotine Addiction 32 99.68 Very High Very High Very High
Neuropathic Pain 343 99.42 Very High Very High Very High
Ganglion Cysts 352 99.28 Very High Very High Very High
Nociception 50 99.04 Very High Very High Very High
Hypersensitivity 39 98.78 Very High Very High Very High
Injury 125 98.56 Very High Very High Very High
Hyperalgesia 51 98.24 Very High Very High Very High
Pain 234 97.84 Very High Very High Very High
Temporomandibular Joint Syndrome 336 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, nicotine upregulates the expression of P2Y12 receptors on vascular cells and megakaryoblasts, and smokers exhibit higher P2Y12 expression [21].
Gene_expression (expression) of P2Y12 in megakaryoblasts associated with nicotine addiction and nicotine
1) Confidence 0.75 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2048504 Disease Relevance 1.42 Pain Relevance 0.11
Moreover, nicotine upregulates the expression of P2Y12 receptors on vascular cells and megakaryoblasts, and smokers exhibit higher P2Y12 expression [21].
Gene_expression (expression) of P2Y12 in megakaryoblasts associated with nicotine addiction and nicotine
2) Confidence 0.75 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2048504 Disease Relevance 1.29 Pain Relevance 0.11
This observation correlates with previous reports indicating that, unlike other extracellular nucleotide receptors, such as the P2X4, P2X7, and P2Y6 receptor subtypes [53,67], P2Y12 receptor expression is restricted to CNS microglia [56,68].
Gene_expression (expression) of P2Y12 in microglia associated with central nervous system
3) Confidence 0.74 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017032 Disease Relevance 1.06 Pain Relevance 0.79
For GFAP-, Iba1- and P2Y12- receptor immunostaining, the mean pixel intensity values were expressed as fold increase compared to the contralateral side of saline injected animals set to 1.0.
Gene_expression (expressed) of P2Y12
4) Confidence 0.65 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017032 Disease Relevance 0.36 Pain Relevance 0.44
Reverse transcriptase polymerase chain reaction (RT-PCR) analysis revealed that mRNAs encoding P2Y12 and P2Y13 receptors are expressed in the brainstem, whereas P2Y13 but not P2Y12 receptor mRNA is present in the dorsal root ganglion and spinal cord.
Gene_expression (expressed) of P2Y12 in brainstem associated with ganglion cysts, dorsal root ganglion, medulla and spinal cord
5) Confidence 0.64 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18063000 Disease Relevance 0.10 Pain Relevance 0.80
Microglia also express G protein-coupled ATP receptors [e.g., P2Y6 receptor (P2Y6R) and P2Y12R].
Gene_expression (express) of P2Y12R in Microglia
6) Confidence 0.59 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072920 Disease Relevance 0.84 Pain Relevance 1.00
In the brainstem, no P2Y12 receptor expression was observed in either GFAP+ astrocytes (Figure 7C), or NeuN+ neurons (Figure 7D).
Gene_expression (expression) of P2Y12 in neurons associated with medulla
7) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017032 Disease Relevance 0.40 Pain Relevance 0.59
It is worth mentioning that in a different model of inflammatory pain (i.e., the injection of CFA in the hindpaw) the intraperitoneal administration of the P2Y12 receptor antagonist 2,2-dimethyl-propionic acid 3-(2-chloro-6-methylaminopurin-9-yl)-2-(2,2-dimethyl-propionyloxymethyl)-propylester (MRS2395) significantly alleviated the mechanical hypersensitivity [69], but authors did not evaluated the possible changes in P2Y12 receptor expression in their experimental model.
Gene_expression (expression) of P2Y12 associated with antagonist, eae and hypersensitivity
8) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017032 Disease Relevance 0.82 Pain Relevance 0.57
The purinergic P2Y12 receptor is selectively expressed by microglial cells in the CNS, but it is not up-regulated following TMJ inflammation
Gene_expression (expressed) of P2Y12 in microglial cells associated with snapping jaw, inflammation and central nervous system
9) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017032 Disease Relevance 0.73 Pain Relevance 0.63
On this basis, we analyzed the possible changes of P2Y12 receptor expression in our inflammatory model.
Gene_expression (expression) of P2Y12 associated with inflammation
10) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017032 Disease Relevance 0.99 Pain Relevance 0.70
Taken together, these results demonstrate that the expression of the purinergic P2Y12 receptor, which has been implicated in some forms of pain sensations, is not modified in the subacute reaction of CNS glial cells to TMJ inflammation.


Gene_expression (expression) of P2Y12 in CNS glial cells associated with pain, snapping jaw, inflammation and central nervous system
11) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017032 Disease Relevance 0.62 Pain Relevance 0.88
Since the purinergic system has been implicated in the activation of microglial cells during neuropathic pain, we have also evaluated the expression of the microglial-specific P2Y12 receptor subtype.
Gene_expression (expression) of P2Y12 in microglial cells associated with neuropathic pain
12) Confidence 0.58 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC3017032 Disease Relevance 1.05 Pain Relevance 0.81
These aspects of P2Y12 signalling are particularly interesting if we consider the role these receptors play in microglial chemotaxis induced by adenine nucleotides [23] and the observation that microglia are the only cells belonging to the monocyte/macrophage lineage that express P2Y12 receptors [41].
Gene_expression (express) of P2Y12 in macrophage
13) Confidence 0.55 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0 Pain Relevance 0.07
In the case of P2Y12 receptors activated by ADP, the G??
Gene_expression (receptors) of P2Y12
14) Confidence 0.48 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0 Pain Relevance 0.03
Microglia, which are thought to be residential macrophages in the CNS, express P2 purinoceptors, mainly P2X4 and P2X7 as well as P2Y2, P2Y6, and P2Y12 [4].
Gene_expression (express) of P2Y12 in CNS associated with central nervous system
15) Confidence 0.46 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072920 Disease Relevance 0.55 Pain Relevance 0.66
(a) In microglial cells, we found the expression of P2Y2, P2Y6, P2Y12 and P2Y14 receptors.
Gene_expression (expression) of P2Y12 in microglial cells
16) Confidence 0.43 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0 Pain Relevance 0.03
However, when the P2Y12 receptor was expressed in these neurons, no inhibition of IM by nucleotides could be observed [14].
Gene_expression (expressed) of P2Y12 in neurons
17) Confidence 0.40 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0.10 Pain Relevance 0.12
Purinergic receptors expressed in microglia (P2X4, P2X7 and P2Y12) are implicated in neuropathic pain [12,13,33,34].
Gene_expression (expressed) of P2Y12 in microglia associated with neuropathic pain
18) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2690582 Disease Relevance 0.41 Pain Relevance 0.69
A more unexpected finding was that the Gq/11-linked P2Y1 receptor, when co-expressed with Kir3.1 and 3.2 subunits instead of P2Y12, also produced a PTX-sensitive activation of GIRK.
Gene_expression (expressed) of P2Y12
19) Confidence 0.35 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0.08 Pain Relevance 0.12
In in situ hybridizations of brain sections, the expression pattern of P2Y12 was consistent with a predominantly glial localization [25, 32].
Gene_expression (expression) of P2Y12 in brain
20) Confidence 0.31 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0.12 Pain Relevance 0.38

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