INT148308

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 8
Total Number 13
Disease Relevance 6.20
Pain Relevance 6.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2ry12) plasma membrane (P2ry12) signal transducer activity (P2ry12)
Anatomy Link Frequency
platelet 2
spinal cord 1
brainstem 1
spinal trigeminal nucleus 1
trigeminal nerve 1
P2ry12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 195 100.00 Very High Very High Very High
Glutamate 46 100.00 Very High Very High Very High
noradrenaline 9 100.00 Very High Very High Very High
antagonist 57 99.96 Very High Very High Very High
Snapping jaw 210 98.92 Very High Very High Very High
medulla 67 98.64 Very High Very High Very High
Neuropathic pain 70 98.44 Very High Very High Very High
fifth nerve 35 98.32 Very High Very High Very High
Dopamine 126 98.24 Very High Very High Very High
Central nervous system 138 98.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 201 100.00 Very High Very High Very High
Temporomandibular Joint Syndrome 210 98.92 Very High Very High Very High
Neuropathic Pain 168 98.44 Very High Very High Very High
Adhesions 2 98.34 Very High Very High Very High
Diabetes Mellitus 151 97.72 Very High Very High Very High
Coronary Artery Disease 47 96.28 Very High Very High Very High
Hypersensitivity 31 94.40 High High
INFLAMMATION 271 93.20 High High
Pain 133 92.64 High High
Increased Venous Pressure Under Development 7 90.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, Hetherington et al [19] reported no significant effect of P2RY12 SNPs, including the i-T744C one, on platelet response to ADP in subjects without history of CAD, and an association of a common variant in P2Y1 gene with platelet reactivity.
Neg (no) Regulation (effect) of P2RY12 in platelet associated with coronary artery disease
1) Confidence 0.44 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2048504 Disease Relevance 0.67 Pain Relevance 0.09
In conclusion, inhibitory P2Y and facilitatory P2X1-like receptors, involved in the regulation of glutamate (P2Y13 and/or P2Y1) and noradrenaline (P2Y13 and/or P2Y1, P2Y12) release have been identified, which provide novel target sites for analgesics acting at the spinal cord level.
Regulation (regulation) of P2Y12 in spinal cord associated with glutamate, analgesic, noradrenaline and spinal cord
2) Confidence 0.43 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18063000 Disease Relevance 0.09 Pain Relevance 0.74
S also affects the P2Y12 receptor [66].
Regulation (affects) of P2Y12 receptor
3) Confidence 0.33 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096569 Disease Relevance 0 Pain Relevance 0.51
However, when the selective P2Y12 receptor antagonist AR-C 69931MX [67] was perfused together with ADP?
Regulation (selective) of P2Y12 receptor associated with antagonist
4) Confidence 0.33 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096569 Disease Relevance 0 Pain Relevance 0.51
Quite surprisingly, we detected no changes in microglial P2Y12 receptor levels after the injection of CFA in the TMJ, suggesting that this receptor is not up-regulated during the first phases of tissue hypersensitivity following an inflammatory stimulus.
Neg (no) Regulation (changes) of P2Y12 associated with snapping jaw, hypersensitivity and inflammatory stimuli
5) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017032 Disease Relevance 1.07 Pain Relevance 0.76
We next evaluated whether P2Y12 receptor levels in the spinal trigeminal nucleus were affected by CFA injection into the TMJ or not.
Spec (whether) Regulation (affected) of P2Y12 in spinal trigeminal nucleus associated with snapping jaw
6) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017032 Disease Relevance 0.28 Pain Relevance 0.54
Despite the observed upregulation of Iba1 immunoreactivity and the morphological changes observed in microglial cells (see above), no increase in P2Y12 receptor immunoreactivity in the ipsilateral side of CFA-injected rats was observed in either the trigeminal subnucleus caudalis (p = 0.957 and p = 0.968 at 24 h and 72 h respectively; n = 7 animals) (Figure 8A-B) or in the cervical dorsal horn (p = 0.734 and p = 0.923 at 24 h and 72 h respectively; n = 7 animals) (Figure 8C-D).
Regulation (immunoreactivity) of P2Y12 in microglial cells associated with dorsal horn
7) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017032 Disease Relevance 0.33 Pain Relevance 0.68
Interestingly, in the same tissue sections P2Y12 receptor immunoreactivity was detected at the boundary between the trigeminal nerve root (i.e., the PNS) and the CNS (Figure 7B), thus indicating that the expression of this receptor subtype is probably restricted to cells of the CNS.
Regulation (immunoreactivity) of P2Y12 in trigeminal nerve associated with fifth nerve, peripheral nervous system and central nervous system
8) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017032 Disease Relevance 0.66 Pain Relevance 0.67
In this review, we describe the modification of neuropathic pain sensation through microglial P2X4 and P2X7, with the possibility of P2Y6 and P2Y12 involvement.



Spec (possibility) Regulation (involvement) of P2Y12 associated with neuropathic pain
9) Confidence 0.20 Published 2007 Journal Purinergic Signal Section Abstract Doc Link PMC2072920 Disease Relevance 0.70 Pain Relevance 0.50
By contrast, the mRNA levels of P2X7 and P2Y12 receptors were not changed.
Neg (not) Regulation (changed) of P2Y12
10) Confidence 0.15 Published 2009 Journal Mol Pain Section Body Doc Link PMC2690582 Disease Relevance 0.49 Pain Relevance 0.75
ED1 immunoreactivity in the TG, and GFAP, Iba1 and P2Y12 receptor immunoreactivity in the brainstem was assessed by densitometric analysis.
Regulation (immunoreactivity) of P2Y12 in brainstem associated with medulla and trigeminal ganglion
11) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017032 Disease Relevance 0.49 Pain Relevance 0.43
P2Y12 receptor responses were inhibited with 0.2 mM GSNO and higher concentrations (Figure 2, Supplementary Figure 1 [see additional file 1]).
Regulation (responses) of P2Y12
12) Confidence 0.10 Published 2005 Journal BMC Cell Biol Section Body Doc Link PMC1090567 Disease Relevance 0 Pain Relevance 0
Platelet function is regulated by insulin38,39 which in normal conditions antagonizes the effect of a number of agonists;40 the adhesion or aggregation of platelets is upregulated in insulin-resistant subjects.17,41 Up-regulation of the P2Y12 ADP receptor signaling pathway has been shown in type 2 DM platelets, thus contributing to increased platelet reactivity in these patients.16
Regulation (regulation) of P2Y12 in platelets associated with diabetes mellitus, agonist and adhesions
13) Confidence 0.06 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672443 Disease Relevance 1.42 Pain Relevance 0.05

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