INT14831

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Context Info
Confidence 0.50
First Reported 1991
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 8.71
Pain Relevance 4.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNC) extracellular space (TNC) extracellular region (TNC)
cell adhesion (TNC)
Anatomy Link Frequency
cartilage 1
extracellular matrix 1
TNC (Homo sapiens)
Pain Link Frequency Relevance Heat
Trigeminal neuralgia 73 100.00 Very High Very High Very High
Analgesic 14 99.98 Very High Very High Very High
Nav1.7 4 99.90 Very High Very High Very High
nav1.3 4 99.40 Very High Very High Very High
local anesthetic 3 99.00 Very High Very High Very High
Gabapentin 17 98.98 Very High Very High Very High
Pain 121 96.68 Very High Very High Very High
Snapping jaw 4 96.20 Very High Very High Very High
palliative 35 94.72 High High
nav1.8 3 93.60 High High
Disease Link Frequency Relevance Heat
Neuralgia 72 100.00 Very High Very High Very High
Headache 9 100.00 Very High Very High Very High
Adhesions 5 99.20 Very High Very High Very High
Recurrence 19 99.00 Very High Very High Very High
Emergencies 3 98.92 Very High Very High Very High
Psychosis 47 98.64 Very High Very High Very High
Shock 1 97.76 Very High Very High Very High
Pain 127 96.68 Very High Very High Very High
Arrhythmias 2 Under Development 84 96.56 Very High Very High Very High
Temporomandibular Joint Syndrome 3 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The migratory ability of haSMCs was impaired in a dose-dependent manner and the extracellular matrix protein tenascin was reduced.
Negative_regulation (reduced) of tenascin in extracellular matrix
1) Confidence 0.50 Published 2003 Journal Cell Biol. Int. Section Abstract Doc Link 14642530 Disease Relevance 0.06 Pain Relevance 0.06
RESULTS: Many pathophysiological factors may be involved in the occurrence of adenomyosis: immunological factors, estrogen sulfatase activity, tenascin which is a fibronectin inhibitor and angiogenesis and growth factors such as EGF, VEGF and GM-CSF.
Negative_regulation (inhibitor) of tenascin
2) Confidence 0.42 Published 2004 Journal J Gynecol Obstet Biol Reprod (Paris) Section Body Doc Link 15687941 Disease Relevance 0 Pain Relevance 0
Massive deposition of fibronectin and tenascin was observed adjacent to the implant surface.
Negative_regulation (deposition) of tenascin
3) Confidence 0.41 Published 2004 Journal J. Autoimmun. Section Abstract Doc Link 15236756 Disease Relevance 0.61 Pain Relevance 0.13
Barker, et al., reported several predictive factors for recurrence of TN after MVD, including female sex and a longer preoperative history of TN [24].
Negative_regulation (history) of TN associated with trigeminal neuralgia and recurrence
4) Confidence 0.37 Published 2008 Journal Head Face Med Section Body Doc Link PMC2474589 Disease Relevance 1.02 Pain Relevance 0.29
A decrease in TN concentration during chemotherapy may therefore indicate change of treatment.
Negative_regulation (decrease) of TN
5) Confidence 0.36 Published 1998 Journal APMIS Suppl. Section Abstract Doc Link 9868384 Disease Relevance 0.74 Pain Relevance 0.09
Furthermore, patients receiving chemotherapy may be monitored by s/p-TN measurements, as a decrease in TN concentration indicated recurrence 3.6 months prior to clinical diagnosis.
Negative_regulation (decrease) of TN associated with recurrence
6) Confidence 0.36 Published 1998 Journal APMIS Suppl. Section Abstract Doc Link 9868384 Disease Relevance 0.82 Pain Relevance 0.09
Participants described GP consultations for monitoring their conditions; such consultations were much less common for the LFCs.
Negative_regulation (described) of GP
7) Confidence 0.24 Published 2008 Journal Family Practice Section Body Doc Link PMC2440493 Disease Relevance 0.08 Pain Relevance 0.08
Six had the private telephone number of their GP to be used when needed in emergencies or if advice was needed regarding medical treatment.
Negative_regulation (number) of GP associated with emergencies
8) Confidence 0.21 Published 2008 Journal BMC Palliat Care Section Body Doc Link PMC2553051 Disease Relevance 0.15 Pain Relevance 0
We found that Nav1.7 was downregulated in TN (P=0.017) and Nav1.3 was upregulated in these patients (P=0.043).
Negative_regulation (downregulated) of TN associated with nav1.3, trigeminal neuralgia and nav1.7
9) Confidence 0.20 Published 2009 Journal Neuroscience Section Abstract Doc Link 19699781 Disease Relevance 1.07 Pain Relevance 2.00
Development of GP's interest in providing care for psychotic patients could be stimulated in several ways.
Negative_regulation (Development) of GP associated with psychosis
10) Confidence 0.18 Published 2007 Journal BMC Fam Pract Section Body Doc Link PMC1933537 Disease Relevance 0.59 Pain Relevance 0
Other approaches using gabapentin, namely when associated with peripheral analgesic block of TN trigger points with the local anesthetic ropivacaine (ROP), resulted in decreased pain and daily drug intake (reduced side effects).
Negative_regulation (block) of TN associated with pain, analgesic, trigeminal neuralgia, gabapentin and local anesthetic
11) Confidence 0.13 Published 2010 Journal Journal of pain research Section Abstract Doc Link PMC3004633 Disease Relevance 0.74 Pain Relevance 1.62
We found an indirect indication for this, because complementary-medicine GP were somewhat overrepresented in our GP sample compared to the data base for all GPs.
Negative_regulation (overrepresented) of GP
12) Confidence 0.07 Published 2006 Journal BMC Public Health Section Body Doc Link PMC1635563 Disease Relevance 0.24 Pain Relevance 0.08
CI: confidence interval; CT: computerized tomography; FN: false negative; FP: false positive; NPV: negative predictive value; OR: odds ratio; PPV: positive predictive value; SD: standard deviation; Se: sensitivity; Sp: specificity; TBNA: transbronchial needle aspiration; TN: true negative; TP: true positive.


Negative_regulation (sensitivity) of TN
13) Confidence 0.03 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2868821 Disease Relevance 0.15 Pain Relevance 0
CI: confidence interval; CT: computerized tomography; FN: false negative; FP: false positive; NPV: negative predictive value; OR: odds ratio; PPV: positive predictive value; SD: standard deviation; Se: sensitivity; Sp: specificity; TBNA: transbronchial needle aspiration; TN: true negative; TP: true positive.


Negative_regulation (aspiration) of TN
14) Confidence 0.03 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2868821 Disease Relevance 0.14 Pain Relevance 0
CI: confidence interval; CT: computerized tomography; FN: false negative; FP: false positive; NPV: negative predictive value; OR: odds ratio; PPV: positive predictive value; SD: standard deviation; Se: sensitivity; Sp: specificity; TBNA: transbronchial needle aspiration; TN: true negative; TP: true positive.


Negative_regulation (needle) of TN
15) Confidence 0.03 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2868821 Disease Relevance 0.14 Pain Relevance 0
The distribution of type I and II collagens, fibronectin and the fibronectin-integrin receptor, tenascin, laminin, link protein, and cartilage-specific glycosaminoglycans was examined in the primate temporomandibular joint complex using an immunohistochemical approach.
Spec (examined) Negative_regulation (distribution) of tenascin in cartilage associated with snapping jaw
16) Confidence 0.01 Published 1991 Journal J. Oral Maxillofac. Surg. Section Abstract Doc Link 1706426 Disease Relevance 0.17 Pain Relevance 0.17
For this purpose, a temporary GP block without permanent destruction of GP using BT would be a novel management.
Negative_regulation (block) of GP
17) Confidence 0.01 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2933463 Disease Relevance 0.64 Pain Relevance 0
However, short-term GP block would be applicable in some clinical field, such as prevention of post-cardiac surgery AF, although its mechanism has not been well-established.
Negative_regulation (block) of GP associated with arrhythmias 2 under development
18) Confidence 0.01 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2933463 Disease Relevance 0.64 Pain Relevance 0
Long-term effects of GP block utilizing radiofrequency ablation on cardiac innervation might be difficult to achieve.
Negative_regulation (block) of GP
19) Confidence 0.01 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2933463 Disease Relevance 0.71 Pain Relevance 0

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