INT148326

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Context Info
Confidence 0.76
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 5.38
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Pkd1) plasma membrane (Pkd1) nucleus (Pkd1)
cilium (Pkd1) biological_process (Pkd1)
Anatomy Link Frequency
DRG 6
Pkd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 12 99.76 Very High Very High Very High
Inflammation 12 84.12 Quite High
Pain 6 80.44 Quite High
fibrosis 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 30 99.52 Very High Very High Very High
Polycystic Kidney Disease 72 98.56 Very High Very High Very High
Targeted Disruption 14 98.04 Very High Very High Very High
Disease 52 95.28 Very High Very High Very High
Cancer 20 91.32 High High
Cyst 42 89.16 High High
Apoptosis 64 85.76 High High
INFLAMMATION 12 84.12 Quite High
Pain 6 80.44 Quite High
Disease Progression 8 62.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Electrophysiological measurements indicated that DRG with overexpression of PKD1 were more sensitive to low dose capsaicin than those expressing DN-PKD1.
Gene_expression (overexpression) of PKD1 in DRG associated with qutenza
1) Confidence 0.76 Published 2008 Journal Pain Section Abstract Doc Link 18063480 Disease Relevance 0.53 Pain Relevance 0.32
Furthermore, overexpressed PKD1 could up regulate, whereas PKD1 antisense could knock down TRPV1 content in DRG through posttranscriptional regulation manner.
Gene_expression (overexpressed) of PKD1 in DRG associated with targeted disruption
2) Confidence 0.76 Published 2008 Journal Pain Section Abstract Doc Link 18063480 Disease Relevance 0.50 Pain Relevance 0.31
Electrophysiological measurements indicated that DRG with overexpression of PKD1 were more sensitive to low dose capsaicin than those expressing DN-PKD1.
Gene_expression (expressing) of PKD1 in DRG associated with qutenza
3) Confidence 0.76 Published 2008 Journal Pain Section Abstract Doc Link 18063480 Disease Relevance 0.52 Pain Relevance 0.32
The average magnitude of the peak inward current evoked by capsaicin was greater in the DRG overexpressing PKD1 than in those expressing DN-PKD1.
Gene_expression (expressing) of PKD1 in DRG associated with qutenza
4) Confidence 0.76 Published 2008 Journal Pain Section Abstract Doc Link 18063480 Disease Relevance 0.50 Pain Relevance 0.32
The average magnitude of the peak inward current evoked by capsaicin was greater in the DRG overexpressing PKD1 than in those expressing DN-PKD1.
Gene_expression (overexpressing) of PKD1 in DRG associated with qutenza
5) Confidence 0.76 Published 2008 Journal Pain Section Abstract Doc Link 18063480 Disease Relevance 0.51 Pain Relevance 0.32
Likewise, overexpression of PKD1 in DRG significantly enhanced, while dominant negative PKD1 (DN-PKD1) partly attenuated, heat hypersensitivity.
Gene_expression (overexpression) of PKD1 in DRG associated with hypersensitivity
6) Confidence 0.76 Published 2008 Journal Pain Section Abstract Doc Link 18063480 Disease Relevance 0.52 Pain Relevance 0.25
Germino et al[9] were the first to suggest a relationship between p21 and PKD by showing that p21 is induced by the product of the Pkd1 gene, polycystin-1.
Gene_expression (product) of polycystin-1
7) Confidence 0.44 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 0.86 Pain Relevance 0
In this study, we have built on the observation that polycystin-1, the gene product of PKD1 which is mutated in 85% of ADPKD cases, induces the cyclin kinase inhibitor p21[9].
Gene_expression (product) of polycystin-1 associated with polycystic kidney disease
8) Confidence 0.40 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 1.43 Pain Relevance 0

General Comments

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