INT148327

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Context Info
Confidence 0.52
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 2.23
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pkd1, Trpv1) cytosol (Trpv1) Golgi apparatus (Pkd1)
nucleus (Pkd1) cilium (Pkd1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
DRG 3
Pkd1 (Rattus norvegicus)
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 8 99.68 Very High Very High Very High
Pain 4 99.24 Very High Very High Very High
qutenza 8 89.80 High High
Disease Link Frequency Relevance Heat
Hypersensitivity 20 99.72 Very High Very High Very High
INFLAMMATION 8 99.68 Very High Very High Very High
Pain 4 99.24 Very High Very High Very High
Targeted Disruption 4 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We concluded that PKD1 in DRG, through interaction with TRPV1, is involved in developing and maintaining inflammatory heat hypersensitivity.
PKD1 Binding (interaction) of TRPV1 in DRG associated with inflammation and hypersensitivity
1) Confidence 0.52 Published 2008 Journal Pain Section Abstract Doc Link 18063480 Disease Relevance 0.61 Pain Relevance 0.25
Both PKD1 and TRPV1 were translocated to the cytoplasmic membrane in DRG 6 h after CFA treatment and, at that time, PKD1 interacted with TRPV1 by co-immunoprecipitation in DRG.
PKD1 Binding (interacted) of TRPV1 in DRG
2) Confidence 0.52 Published 2008 Journal Pain Section Abstract Doc Link 18063480 Disease Relevance 0.55 Pain Relevance 0.30
Both PKD1 and TRPV1 were translocated to the cytoplasmic membrane in DRG 6 h after CFA treatment and, at that time, PKD1 interacted with TRPV1 by co-immunoprecipitation in DRG.
PKD1 Binding (interacted) of TRPV1 in DRG
3) Confidence 0.39 Published 2008 Journal Pain Section Abstract Doc Link 18063480 Disease Relevance 0.57 Pain Relevance 0.31
In the current study we assessed the involvement of PKD1 in pain modulation and explored the possible interaction between PKD1 and TRPV1 in rat inflammatory heat hypersensitivity.
PKD1 Binding (interaction) of TRPV1 associated with pain, inflammation and hypersensitivity
4) Confidence 0.39 Published 2008 Journal Pain Section Abstract Doc Link 18063480 Disease Relevance 0.50 Pain Relevance 0.15

General Comments

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