INT14837

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Context Info
Confidence 0.60
First Reported 1991
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 10.69
Pain Relevance 3.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PLA2G1B) extracellular space (PLA2G1B) extracellular region (PLA2G1B)
Anatomy Link Frequency
macrophages 1
endothelial cells 1
smooth muscle 1
monocytes 1
brain 1
PLA2G1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 8 99.52 Very High Very High Very High
rheumatoid arthritis 366 98.80 Very High Very High Very High
ischemia 2 98.08 Very High Very High Very High
Arthritis 31 96.36 Very High Very High Very High
Inflammation 167 95.16 Very High Very High Very High
induced neuropathy 1 93.36 High High
chemokine 85 83.80 Quite High
iatrogenic 2 83.28 Quite High
cytokine 57 83.20 Quite High
Inflammatory response 3 76.32 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 6 99.66 Very High Very High Very High
Pancreatitis 30 99.52 Very High Very High Very High
Rheumatoid Arthritis 366 98.80 Very High Very High Very High
Cv General 4 Under Development 4 98.44 Very High Very High Very High
Injury 13 97.56 Very High Very High Very High
Epilepsy 1 97.24 Very High Very High Very High
Disease 56 96.72 Very High Very High Very High
Arthritis 31 96.36 Very High Very High Very High
INFLAMMATION 166 95.16 Very High Very High Very High
Brain Injury 1 93.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum PLA2 levels were low in chronic pancreatitis with severe exocrine insufficiency and advanced pancreatic cancer.
Gene_expression (levels) of PLA2 associated with pancreatic cancer and chronic pancreatitis
1) Confidence 0.60 Published 1991 Journal Gastroenterol. Jpn. Section Abstract Doc Link 1706672 Disease Relevance 1.09 Pain Relevance 0.29
Frequency of abnormal serum PLA2 levels was 60% in chronic pancreatitis (n = 52) and 67% in pancreatic cancer (n = 61).
Gene_expression (levels) of PLA2 associated with pancreatic cancer and chronic pancreatitis
2) Confidence 0.60 Published 1991 Journal Gastroenterol. Jpn. Section Abstract Doc Link 1706672 Disease Relevance 0.99 Pain Relevance 0.27
To test its clinical usefulness, specimens mainly from patients with pancreatic diseases were obtained and examined for serum P-PLA2 levels.
Spec (examined) Gene_expression (levels) of P-PLA2 associated with pancreatitis
3) Confidence 0.41 Published 1993 Journal Kaku Igaku Section Abstract Doc Link 8230832 Disease Relevance 0.56 Pain Relevance 0.11
In patients with chronic pancreatitis (n = 93) and pancreatic cancer (n = 37), serum P-PLA2 levels showed a wide range of distribution, from abnormally elevated values to abnormally low values.
Gene_expression (levels) of P-PLA2 associated with pancreatic cancer and chronic pancreatitis
4) Confidence 0.41 Published 1993 Journal Kaku Igaku Section Abstract Doc Link 8230832 Disease Relevance 0.61 Pain Relevance 0.13
Expression of the inducible oxidoreductase cyclooxygenase-2 and cytosolic phospholipase A2 (cPLA2) are strongly activated during cerebral ischemia and trauma, epilepsy and AD, indicating the induction of proinflammatory gene pathways as a response to brain injury.
Gene_expression (Expression) of phospholipase A2 in brain associated with epilepsy, cv general 4 under development, ischemia, injury, disease and brain injury
5) Confidence 0.27 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11059791 Disease Relevance 1.42 Pain Relevance 0.25
Levels of secretory phospholipase A2 (sPLA2) were determined using a sandwich immunometric assay (Cayman Corporation, Michigan, USA) and the interassay CV of NHP was 5.37%.
Gene_expression (Levels) of phospholipase A2
6) Confidence 0.16 Published 2010 Journal International Journal of Vascular Medicine Section Body Doc Link PMC2989863 Disease Relevance 0.48 Pain Relevance 0
Moreover, in vitro studies have revealed that APC causes a dose-dependent inhibition of interferon-induced expression of phospholipase A2 [45] and upregulation of cyclooxygenase II expression in endothelial cells [46].
Gene_expression (expression) of phospholipase A2 in endothelial cells
7) Confidence 0.09 Published 2008 Journal Crit Care Section Body Doc Link PMC2646309 Disease Relevance 1.01 Pain Relevance 0.17
Eicosanoids are defined as prostaglandins, leukotrienes, and other compounds that are products of the action of phospholipase A2 on the cellular phospholipid membrane and are, in general, derived from the production of arachidonic acid (Figure 1).
Gene_expression (products) of phospholipase A2
8) Confidence 0.07 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693998 Disease Relevance 0.99 Pain Relevance 0.54
Epidermal melanocytes expressed cytoplasmic phospholipase-A2, cyclooxygenase-1, cytoplasmic prostaglandin-E synthase and microsomal prostaglandin-E synthase-1, -2.
Gene_expression (expressed) of cytoplasmic phospholipase-A2 in melanocytes
9) Confidence 0.06 Published 2010 Journal Pigment Cell & Melanoma Research Section Abstract Doc Link PMC2881306 Disease Relevance 0.17 Pain Relevance 0.08
In this context, phospholipase A2 activating protein has been shown to be present in a variety of cells in the RA synovium, including endothelial cells, vascular smooth muscle and monocytes/macrophages [134].
Gene_expression (present) of phospholipase A2 in monocytes associated with rheumatoid arthritis
10) Confidence 0.05 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 1.07 Pain Relevance 0.54
In vertebrates, the relative importance of NTE and calcium-independent phospholipase A2 for homeostatic PtdCho deacylation in particular cell types, possible interactions of NTE with Sec14p homologues and cyclic AMP, and whether deranged phospholipid metabolism underlies organophosphate-induced neuropathy are areas which require further investigation.
Gene_expression (deacylation) of phospholipase A2 associated with induced neuropathy and neuropathic pain
11) Confidence 0.04 Published 2005 Journal Biochim. Biophys. Acta Section Abstract Doc Link 16137924 Disease Relevance 0.17 Pain Relevance 0.09
In this context, phospholipase A2 activating protein has been shown to be present in a variety of cells in the RA synovium, including endothelial cells, vascular smooth muscle and monocytes/macrophages [134].
Gene_expression (present) of phospholipase A2 in macrophages associated with rheumatoid arthritis
12) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 1.07 Pain Relevance 0.54
In this context, phospholipase A2 activating protein has been shown to be present in a variety of cells in the RA synovium, including endothelial cells, vascular smooth muscle and monocytes/macrophages [134].
Gene_expression (present) of phospholipase A2 in smooth muscle associated with rheumatoid arthritis
13) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 1.07 Pain Relevance 0.54

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