INT148382

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Context Info
Confidence 0.23
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.88
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (JAG1) structural molecule activity (JAG1) plasma membrane (JAG1)
Anatomy Link Frequency
epithelial cell 1
meninges 1
ducts 1
body 1
JAG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 8 95.76 Very High Very High Very High
Inflammation 4 68.80 Quite High
backache 1 30.00 Quite Low
cva 6 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alagille Syndrome 65 100.00 Very High Very High Very High
Cancer 74 99.80 Very High Very High Very High
Congenital Anomalies 41 99.46 Very High Very High Very High
Melanoma 27 98.32 Very High Very High Very High
Pancreatitis 8 95.76 Very High Very High Very High
Body Weight 10 94.92 High High
Meningioma 3 87.12 High High
Metaplasia 1 72.64 Quite High
INFLAMMATION 4 68.80 Quite High
Hypertension 4 65.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The LR for existing vertebral deformities was highest with positive results for both WOD and AHD; the LR value in this scenario was nearly equivalent to the LR from the full logistical regression diagnostic model for which body weight was included (Figure 2).


Positive_regulation (results) of AHD in body associated with body weight, alagille syndrome and congenital anomalies
1) Confidence 0.23 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2613887 Disease Relevance 1.37 Pain Relevance 0
In some patients, i.e. patients #2 and #6, tetramer positive cells increased several fold to over 1% for both Ags tested after DC/Apo-Nec vaccination.
Positive_regulation (increased) of Ags associated with alagille syndrome
2) Confidence 0.16 Published 2008 Journal J Transl Med Section Body Doc Link PMC2265680 Disease Relevance 0.37 Pain Relevance 0
Subsequent immunohistochemical studies have also failed to find cytokeratin expression in the meninges and AGs [44,45,49].
Neg (failed) Spec (find) Positive_regulation (find) of AGs in meninges
3) Confidence 0.15 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0.09 Pain Relevance 0
Thus, epitope peptides derived from gp100 appear to be promising Ags for tumor-specific immunotherapy against malignant melanoma.
Positive_regulation (promising) of Ags associated with alagille syndrome, melanoma and cancer
4) Confidence 0.11 Published 2010 Journal J Transl Med Section Body Doc Link PMC2949666 Disease Relevance 0.83 Pain Relevance 0
The transcripts of Delta-like1 and Jagged1 were increased 3.7-fold and 1.3-fold, respectively, while those of HERP1 were elevated 2.4-fold in the ectatic ducts of CP, compared to normal ducts.
Positive_regulation (increased) of Jagged1 in ducts associated with chronic pancreatitis
5) Confidence 0.04 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18069660 Disease Relevance 1.12 Pain Relevance 0.63
In addition to HeLa cells, we found that SM was critical for VacA-mediated vacuolation of AGS and AZ-521 cells, two human gastric epithelial cell lines (Figure S3), as well as for CHO-K1 and Vero cells (data not shown), demonstrating that the importance of plasma membrane SM for toxin function is not idiosyncratic to HeLa cells.
Positive_regulation (vacuolation) of AGS in epithelial cell associated with alagille syndrome
6) Confidence 0.02 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2374909 Disease Relevance 0.10 Pain Relevance 0

General Comments

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