INT148384

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 29.76
Pain Relevance 5.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HEY1) protein binding transcription factor activity (HEY1) DNA binding (HEY1)
transcription factor binding (HEY1) cytoplasm (HEY1)
Anatomy Link Frequency
myocardium 2
pancreatic ducts 2
leukocyte 1
brain 1
sympathetic 1
HEY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 209 100.00 Very High Very High Very High
Osteoarthritis 74 100.00 Very High Very High Very High
Arthritis 18 100.00 Very High Very High Very High
cytokine 301 99.98 Very High Very High Very High
palliative 10 99.46 Very High Very High Very High
rheumatoid arthritis 1270 99.22 Very High Very High Very High
beta blocker 27 98.32 Very High Very High Very High
Chronic pancreatitis 16 97.32 Very High Very High Very High
Etanercept 72 93.44 High High
ischemia 11 93.20 High High
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 1728 100.00 Very High Very High Very High
Pulmonary Disease 177 100.00 Very High Very High Very High
Heart Failure 124 100.00 Very High Very High Very High
Myocardial Infarction 118 100.00 Very High Very High Very High
Osteoarthritis 74 100.00 Very High Very High Very High
Frailty 65 100.00 Very High Very High Very High
Heart Rate Under Development 40 100.00 Very High Very High Very High
Death 35 100.00 Very High Very High Very High
Arthritis 18 100.00 Very High Very High Very High
Chronic Renal Failure 119 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is evidence for involvement of HEY1 in erythroid differentiation: in a mouse cell line, Notch signaling associated with HEY1 upregulation resulted in increased the numbers of erythroid cells [49], whereas in primary human hematopoietic cells upregulation of HEY1 by JUN was associated with a block in erythroid differentiation [50].
Positive_regulation (upregulation) of HEY1 in hematopoietic cells
1) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0.49 Pain Relevance 0
The Notch pathway ligands, Jagged/Delta-like and a Notch target, HES-related repressor protein (HERP), were up-regulated in ectatic compared to normal pancreatic ducts, while another target of Notch, hairy/enhancer of split (HES), was down-regulated.
Positive_regulation (up-regulated) of HES-related repressor protein in pancreatic ducts
2) Confidence 0.29 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18069660 Disease Relevance 1.16 Pain Relevance 0.60
The Notch pathway ligands, Jagged/Delta-like and a Notch target, HES-related repressor protein (HERP), were up-regulated in ectatic compared to normal pancreatic ducts, while another target of Notch, hairy/enhancer of split (HES), was down-regulated.
Positive_regulation (up-regulated) of HERP in pancreatic ducts
3) Confidence 0.29 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18069660 Disease Relevance 1.14 Pain Relevance 0.59
3.2 Whether and to what extent do the preferences with regard to life-sustaining treatments of patients with severe to very severe COPD differ from those of patients with end-stage CHF or CRF?
Positive_regulation (end-stage) of CHF associated with chronic renal failure, pulmonary disease and heart failure
4) Confidence 0.17 Published 2008 Journal BMC Palliat Care Section Body Doc Link PMC2391145 Disease Relevance 1.94 Pain Relevance 0
Consequently, it will be difficult to develop an optimal patient-centred palliative care program for patients with end-stage COPD, CHF or CRF.
Positive_regulation (end-stage) of CHF associated with chronic renal failure, pulmonary disease, heart failure and palliative
5) Confidence 0.17 Published 2008 Journal BMC Palliat Care Section Abstract Doc Link PMC2391145 Disease Relevance 1.78 Pain Relevance 0.10
This dichotomy has important potential implications for human disease and has preliminary support from available clinical studies of TNF inhibitors in humans, in which patients with advanced CHF have shown no benefit or worsened when treated with anti-TNF-?
Positive_regulation (advanced) of CHF associated with cv general 4 under development and disease
6) Confidence 0.17 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 1.51 Pain Relevance 0.19
In contrast, the risk of incident CHF in patients with osteoarthritis (OA), a non-inflammatory arthritis, was not increased compared to non-OA community controls [24].
Neg (not) Positive_regulation (increased) of CHF associated with inflammation, cv general 4 under development, osteoarthritis and arthritis
7) Confidence 0.17 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 2.00 Pain Relevance 0.60
To address this apparent contradiction we next examine the conflicting human clinical experience relating TNF inhibitors to CHF in the context of the available animal data on cytokine-induced CHF.
Positive_regulation (induced) of CHF associated with cv general 4 under development and cytokine
8) Confidence 0.17 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 1.63 Pain Relevance 0.63
Increased sympathetic and reduced vagal activity predict increased mortality in patients with congestive heart failure (CHF).
Positive_regulation (increased) of CHF in sympathetic associated with heart rate under development
9) Confidence 0.16 Published 2009 Journal Conf Proc IEEE Eng Med Biol Soc Section Abstract Doc Link 19964772 Disease Relevance 0.76 Pain Relevance 0.08
Although the role of cardiac natriuretic hormones in the identification and management of individuals with asymptomatic ventricular dysfunction remains to be fully clarified [97], elevated serum levels of brain natriuretic peptide and amino-terminal pro-atrial natriuretic peptide have been associated with an increased risk of subsequent CHF in a community-based epidemiologic study [98].
Positive_regulation (increased) of CHF in brain associated with natriuresis, cv general 4 under development and cv unclassified under development
10) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 1.87 Pain Relevance 0.29
While some traditional risk factors for CHF are over-represented in RA patients, they do not appear to account for all of the increased CHF risk observed.
Positive_regulation (increased) of CHF associated with cv general 4 under development and rheumatoid arthritis
11) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 2.45 Pain Relevance 0.51
In contrast, in patients with RA and no overt CHF, treatment of RA with TNF inhibitors might offer some protection against cytokine induced CHF.


Positive_regulation (induced) of CHF associated with cv general 4 under development, rheumatoid arthritis and cytokine
12) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 1.73 Pain Relevance 0.31
Glucose intolerance/peripheral insulin resistance has, however, been associated with an increase in CHF risk in both cross-sectional [43] and prospective, population-based [40] studies, and may be increased in RA [44,45]

Valvular heart disease

Positive_regulation (increase) of CHF in heart associated with cv general 4 under development, rheumatoid arthritis, coronary heart disease, insulin resistance and impaired glucose tolerance
13) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 2.90 Pain Relevance 0.45
Although studies incorporating direct visualization of myocardial function have yet to be performed in RA patients, clues from animal models of CHF induced by chronic cytokine excess (a setting that may mimic the RA disease state) may serve to explain the apparent contradictions in treatment effects of cytokine inhibition on the myocardium.


Positive_regulation (induced) of CHF in myocardium associated with cv general 4 under development, rheumatoid arthritis, disease and cytokine
14) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 1.33 Pain Relevance 0.51
Both are thought to promote CHF primarily through exacerbation of atherogenesis, though both may also potentiate the release of agents with direct toxicity to the myocardium itself [68,69].
Positive_regulation (promote) of CHF in myocardium associated with toxicity, atherosclerosis and cv general 4 under development
15) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 2.99 Pain Relevance 0.59
35%, despite a high use of beta-blocker (>70%) in both the placebo and the amiodarone group.28 The findings were similar for all causes of CHF.
Positive_regulation (causes) of CHF associated with heart rate under development and beta blocker
16) Confidence 0.09 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922307 Disease Relevance 1.10 Pain Relevance 0.16
Medication treatments for CHF were also comparable for the two groups of patients; a similar percentage (p value > .05) in each group received the two standard medications: ?
Positive_regulation (treatments) of CHF associated with myocardial infarction
17) Confidence 0.08 Published 2004 Journal BMC Med Res Methodol Section Body Doc Link PMC404462 Disease Relevance 0.10 Pain Relevance 0.03
Patients with larger release of CK or CK-MB had an increased risk of death and/or CHF.
Positive_regulation (increased) of CHF associated with heart rate under development and death
18) Confidence 0.03 Published 2005 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC1236947 Disease Relevance 0.81 Pain Relevance 0
After treatment the ACh response increases compared to CHF (Fig. 7a), although not significantly.
Positive_regulation (increases) of CHF associated with frailty
19) Confidence 0.03 Published 2008 Journal Microvasc Res Section Body Doc Link PMC2666799 Disease Relevance 1.20 Pain Relevance 0.10
Here we investigate whether a leukocyte redistribution occurs in CHF and whether this effect is influenced by beta-blocker therapy.


Spec (whether) Positive_regulation (occurs) of CHF in leukocyte associated with beta blocker and myocardial infarction
20) Confidence 0.03 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2713422 Disease Relevance 0.85 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox