INT1484

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Context Info
Confidence 0.35
First Reported 1978
Last Reported 2003
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 5.09
Pain Relevance 3.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pnlip) extracellular region (Pnlip) lipid metabolic process (Pnlip)
Pnlip (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 33 99.78 Very High Very High Very High
alcohol 4 99.68 Very High Very High Very High
fibrosis 2 98.56 Very High Very High Very High
antagonist 2 96.48 Very High Very High Very High
qutenza 1 88.20 High High
Inflammation 1 76.32 Quite High
local anesthetic 1 63.12 Quite High
Disease Link Frequency Relevance Heat
Pancreatitis 34 99.78 Very High Very High Very High
Exocrine Pancreatic Insufficiency 6 99.44 Very High Very High Very High
Necrosis 1 99.18 Very High Very High Very High
Enteropathy 3 98.68 Very High Very High Very High
Fibrosis 2 98.56 Very High Very High Very High
Steatorrhea 14 97.20 Very High Very High Very High
Obesity 4 92.04 High High
Alcohol Addiction 1 79.72 Quite High
Disease 2 79.32 Quite High
INFLAMMATION 1 76.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A majority of spices enhanced the activity of pancreatic lipase and amylase when they are directly in contact with the enzyme.
Positive_regulation (enhanced) of pancreatic lipase
1) Confidence 0.35 Published 2003 Journal Nahrung Section Abstract Doc Link 14727769 Disease Relevance 0 Pain Relevance 0.09
Histological evaluation revealed only mild acinar steatosis and spotty necrosis after 4 weeks of alcohol treatment; the pancreatic enzymes lipase and amylase were not elevated.
Neg (not) Positive_regulation (elevated) of pancreatic enzymes lipase associated with necrosis and alcohol
2) Confidence 0.32 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794907 Disease Relevance 0.59 Pain Relevance 0.33
In 46 patients with chronic pancreatitis the serum increase of pancreatic lipase after secretin stimulation (1 U/kg) was significantly (P less than 0.01) higher than the pancreatic lipase increase in patients with non-pancreatic intestinal disorders and in healthy controls.
Positive_regulation (increase) of pancreatic lipase associated with enteropathy and chronic pancreatitis
3) Confidence 0.21 Published 1985 Journal Klin. Wochenschr. Section Abstract Doc Link 3883051 Disease Relevance 0.77 Pain Relevance 0.51
Of the patients with chronic pancreatitis and a slight to moderate exocrine pancreatic insufficiency 87% show an abnormal serum pancreatic-lipase increase and differ significantly (P less than 0.01) from patients with severe exocrine insufficiency who exhibit an increase of the pancreatic serum lipase only in exceptional cases.
Positive_regulation (increase) of pancreatic-lipase associated with exocrine pancreatic insufficiency and chronic pancreatitis
4) Confidence 0.21 Published 1985 Journal Klin. Wochenschr. Section Abstract Doc Link 3883051 Disease Relevance 0.76 Pain Relevance 0.48
It is concluded, therefore, that Mn2+ and Co2+ inhibit lipolysis by uncoupling cyclic AMP accumulation from activation of triglyceride lipase.
Positive_regulation (activation) of triglyceride lipase
5) Confidence 0.20 Published 1978 Journal Horm. Metab. Res. Section Abstract Doc Link 206497 Disease Relevance 0.31 Pain Relevance 0.15
In 46 patients with chronic pancreatitis the serum increase of pancreatic lipase after secretin stimulation (1 U/kg) was significantly (P less than 0.01) higher than the pancreatic lipase increase in patients with non-pancreatic intestinal disorders and in healthy controls.
Positive_regulation (increase) of pancreatic lipase associated with enteropathy and chronic pancreatitis
6) Confidence 0.12 Published 1985 Journal Klin. Wochenschr. Section Abstract Doc Link 3883051 Disease Relevance 0.74 Pain Relevance 0.51
Serum cathodic trypsin-like immunoreactivity, pancreatic lipase, and pancreatic isoamylase as diagnostic tests of chronic pancreatitis or pancreatic steatorrhea.
Positive_regulation (pancreatic) of pancreatic lipase associated with steatorrhea and chronic pancreatitis
7) Confidence 0.03 Published 1988 Journal Scand. J. Gastroenterol. Section Title Doc Link 3291084 Disease Relevance 1.05 Pain Relevance 0.54
We compared serum concentrations of cathodic trypsin-like immunoreactivity, pancreatic lipase, and pancreatic isoamylase as diagnostic tests of chronic pancreatitis (and of pancreatic steatorrhea in the 41 patients with steatorrhea) in 105 patients (57 men, 48 women) consecutively investigated because of clinical suspicion of chronic pancreatitis.
Positive_regulation (pancreatic) of pancreatic lipase associated with steatorrhea and chronic pancreatitis
8) Confidence 0.03 Published 1988 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 3291084 Disease Relevance 0.87 Pain Relevance 0.40

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