INT148401

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Context Info
Confidence 0.19
First Reported 2003
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 1.19
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrm3) plasma membrane (Chrm3) signal transducer activity (Chrm3)
Anatomy Link Frequency
ileum 2
parasympathetic 1
Chrm3 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 49 100.00 Very High Very High Very High
Potency 32 98.86 Very High Very High Very High
agonist 136 91.68 High High
bradykinin 20 87.68 High High
Kinase C 36 84.28 Quite High
adenocard 18 79.76 Quite High
tetrodotoxin 3 73.48 Quite High
cytokine 16 64.68 Quite High
Delta opioid receptors 2 53.36 Quite High
Dismenorea 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 128 96.84 Very High Very High Very High
Bordatella Infection 9 95.84 Very High Very High Very High
Asthma 86 5.00 Very Low Very Low Very Low
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Disease 20 5.00 Very Low Very Low Very Low
Occupational Lung Diseases 18 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Body Weight 6 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Bronchospasm 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pKb values for these muscarinic receptor antagonists correlated well with the known pKi values of these antagonists for the M3 muscarinic receptor.
Regulation (values) of M3 muscarinic receptor associated with antagonist
1) Confidence 0.19 Published 2008 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 18071676 Disease Relevance 0.21 Pain Relevance 0.21
Then, we used 4-DAMP mustard to inactivate M3 responses in the guinea pig ileum to attempt to reveal direct, M2 receptor-mediated contractions.
Regulation (responses) of M3 in ileum
2) Confidence 0.15 Published 2009 Journal Naunyn Schmiedebergs Arch Pharmacol Section Abstract Doc Link PMC2749929 Disease Relevance 0.48 Pain Relevance 0.08
Following 4-DAMP mustard treatment, the contractile response of the guinea pig ileum to oxotremorine-M exhibited low potency and a competitive-antagonism profile consistent with an M3 response.
Regulation (response) of M3 in ileum associated with potency
3) Confidence 0.15 Published 2009 Journal Naunyn Schmiedebergs Arch Pharmacol Section Abstract Doc Link PMC2749929 Disease Relevance 0.50 Pain Relevance 0.16
Resting ASM tone in vivo is determined primarily by parasympathetic cholinergic innervation acting on ASM m3 mAChRs.
Spec (determined) Regulation (acting) of m3 in parasympathetic
4) Confidence 0.04 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0 Pain Relevance 0.21
Antagonist-mediated up-regulation of GPCRs is relatively unexplored in ASM cells or tissue, although chronic treatment of rabbits with atropine has been shown to up-regulate both m2 and m3 mAChRs in the airway [98].
Regulation (regulate) of m3 associated with antagonist
5) Confidence 0.03 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0 Pain Relevance 0.25

General Comments

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