INT148402

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.54
First Reported 2006
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 95
Total Number 106
Disease Relevance 24.25
Pain Relevance 5.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrm2) plasma membrane (Chrm2) signal transducer activity (Chrm2)
Anatomy Link Frequency
B cells 43
plasma cell 9
T cell 5
plasma 3
A20 3
Chrm2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 62 99.96 Very High Very High Very High
cytokine 1314 99.76 Very High Very High Very High
Somatostatin 2 99.24 Very High Very High Very High
Inflammation 326 97.92 Very High Very High Very High
Dopamine 110 97.92 Very High Very High Very High
agonist 113 96.92 Very High Very High Very High
Central nervous system 12 96.80 Very High Very High Very High
Neurotransmitter 26 96.36 Very High Very High Very High
Serotonin 11 96.00 Very High Very High Very High
addiction 14 95.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Infection 3289 100.00 Very High Very High Very High
Pulmonary Disease 102 99.82 Very High Very High Very High
Psychosis 5 99.72 Very High Very High Very High
Asthma 78 99.64 Very High Very High Very High
Targeted Disruption 409 99.52 Very High Very High Very High
Lymphatic System Cancer 484 99.36 Very High Very High Very High
Viral Infection 105 98.88 Very High Very High Very High
Atherosclerosis 20 98.88 Very High Very High Very High
Cancer 366 98.48 Very High Very High Very High
Cytomegalovirus Infection 579 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both M2 and M3 muscarinic receptor messenger RNAs were detected in the mouse uterus via reverse transcription polymerase chain reaction.
Gene_expression (detected) of M2 in uterus
1) Confidence 0.54 Published 2008 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 18071676 Disease Relevance 0.08 Pain Relevance 0.16
In conclusion, although both M2 and M3 muscarinic receptors were expressed in the mouse uterus, carbachol-induced contractile responses were predominantly mediated by the M3 receptor.
Gene_expression (expressed) of M2 in uterus
2) Confidence 0.47 Published 2008 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 18071676 Disease Relevance 0.06 Pain Relevance 0.14
M2 muscarinic receptors are expressed widely in the brain, whereas M4 receptors predominate in the basal ganglia and cortex [29].
Gene_expression (expressed) of M2 in basal ganglia
3) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268741 Disease Relevance 0.29 Pain Relevance 0.22
M5 muscarinic receptors are preferentially expressed on tegmental dopaminergic neurons, whereas M2 muscarinic receptors are widely expressed, especially on cholinergic cells and terminals [24], [26]–[29].
Gene_expression (expressed) of M2 in dopaminergic neurons
4) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268741 Disease Relevance 0.10 Pain Relevance 0.19
In this study we explored the impact of M2 protein expression in primary murine B cells - a system capable of differentiation.
Gene_expression (expression) of M2 in B cells
5) Confidence 0.37 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.39 Pain Relevance 0
To further investigate the proliferative effects of M2 protein expression in primary murine B cells, the supernatants of the transduced B cells were screened for a variety of cytokines using a mouse cytokine antibody array (see Materials and Methods).
Gene_expression (expression) of M2 in B cells associated with cytokine
6) Confidence 0.37 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0 Pain Relevance 0.16
Together, these data provide strong evidence that M2 expression leads to B cell activation and differentiation similar to a functional activated, pre-plasma memory B cell phenotype, namely CD19+, sIgG+, sIgD?
Gene_expression (expression) of M2 in B cell
7) Confidence 0.37 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.06 Pain Relevance 0
Notably, the dominance of M2-expressing, Thy1.1+ B cells in the M2-transduced cultures was observed repeatedly.
Gene_expression (expressing) of M2 in B cells
8) Confidence 0.37 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.15 Pain Relevance 0
Notably, transfer of culture supernatants from M2 expressing C57Bl/6 B cells, or addition of recombinant murine IL-10, did not result in dominance of the M2.Stop retrovirus transduced (i.e., Thy1.1+) population in the absence of M2 protein expression, leading us to hypothesize that some other function(s) of the M2 protein augments IL-10 signaling.
Gene_expression (expression) of M2 in B cells
9) Confidence 0.37 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.06 Pain Relevance 0
At four days post-transduction, B cells expressing M2 were CD19+, CD25high, GL7high, B220low, I-Ab low, surface IgD?
Gene_expression (expressing) of M2 in B cells
10) Confidence 0.37 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.15 Pain Relevance 0
The increased frequency of live cells in the M2-transduced population versus both the untransduced cells within the culture as well as the control retrovirus transduced population reveals a pro-survival effect of M2 protein expression in B cells.
Gene_expression (expression) of M2 in B cells
11) Confidence 0.37 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.07 Pain Relevance 0
In this study, we measured the roles of these muscarinic receptors on USVs in M2, M4 and M5 knockout and wild-type mice.
Gene_expression (roles) of M2 associated with targeted disruption
12) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268741 Disease Relevance 0.28 Pain Relevance 0.25
This could either be due to the secretion of a “toxic” factor by the M2 expressing cells or competition for a limiting factor necessary for cell survival.
Gene_expression (expressing) of M2
13) Confidence 0.33 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.14 Pain Relevance 0
In this study we show that M2 expression enhanced primary murine B cell survival, proliferation, and differentiation in culture.
Gene_expression (expression) of M2 in B cell
14) Confidence 0.33 Published 2008 Journal PLoS Pathogens Section Abstract Doc Link PMC2270344 Disease Relevance 0.38 Pain Relevance 0
Loss of M2 expression during MHV68 infection correlates with an increase in virus-specific, activated CD8+ T cells
Gene_expression (expression) of M2 in T cells associated with infection
15) Confidence 0.33 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.40 Pain Relevance 0
The latter result suggests that in a mixed culture (M2 expressing and non-expressing cells), the non-transduced primary B cells are actively selected against.
Gene_expression (expressing) of M2 in B cells
16) Confidence 0.33 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.16 Pain Relevance 0
We next examined whether loss of M2 expression and the concomitant reduction in IL-10 expression might alter the CD8 T cell response to MHV68 since IL-10 is known to suppress T cell responses [18].
Gene_expression (expression) of M2 in T cell
17) Confidence 0.33 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.40 Pain Relevance 0
We next addressed whether M2 protein expression altered proliferation in the B cell cultures thereby contributing to the expansion of transduced cells.
Spec (whether) Gene_expression (expression) of M2 in B cell
18) Confidence 0.33 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.07 Pain Relevance 0
These data demonstrate that M2 expression in primary murine B cells leads to enhanced secretion of several cytokines, most notably IL-10.
Gene_expression (expression) of M2 in B cells associated with cytokine
19) Confidence 0.33 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0 Pain Relevance 0.10
Notably, transfer of culture supernatants from M2 expressing C57Bl/6 B cells, or addition of recombinant murine IL-10, did not result in dominance of the M2.Stop retrovirus transduced (i.e., Thy1.1+) population in the absence of M2 protein expression, leading us to hypothesize that some other function(s) of the M2 protein augments IL-10 signaling.
Gene_expression (expressing) of M2 in B cells
20) Confidence 0.33 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.12 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox