INT148403
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Activation of M2 receptors alone did not cause uterine contractions; however, M2 receptor activation enhanced M3 receptor-mediated contractions in the mouse uterus. | |||||||||||||||
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Activation of M2 receptors alone did not cause uterine contractions; however, M2 receptor activation enhanced M3 receptor-mediated contractions in the mouse uterus. | |||||||||||||||
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In trachea, M2 receptor activation opposes forskolin- but not isoproterenol-induced relaxation, which is consistent with the postulate that the ? | |||||||||||||||
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Thus, it seems likely that under some conditions M2 activation of Vav may lead to Blimp-1 expression and entry into the plasma cell program (Fig. 6E). | |||||||||||||||
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This explains why there is little increase in conductance unless both the M2 and the Ca2+-mobilizing M3 receptor are activated simultaneously. | |||||||||||||||
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Circumstantial evidence suggests that the latter is involved in heterologous desensitization, which requires activation of both M2 and M3 receptors and is potently antagonized by M2 selective antagonists (Griffin et al. 2004). | |||||||||||||||
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One is a highly potent M2 receptor-mediated inhibition of forskolin- and ? | |||||||||||||||
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Studies on the mouse uterus are consistent with a conditional role for the M2 receptor in contraction (Kitazawa et al. 2008). | |||||||||||||||
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Stimulation of the M2 receptor activates a nonselective cation conductance; however, the conductance depends on Ca2+ (Bolton 1979; Inoue 1991; Sakamoto et al. 2007). | |||||||||||||||
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M2 is required for differentiation of MHV68 infected B cells to plasma cells | |||||||||||||||
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Because we have previously shown that dose of M2.Stop virus can impact the phenotype observed [18], we assessed whether increasing the dose of M2.Stop from 100 to 1,000 pfu would lead to detectable M2.Stop virus infection of plasma cells. | |||||||||||||||
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The results are consistent with the postulate that 4-DAMP mustard treatment selectively inactivates M3 responses over M2, thereby converting the muscarinic behavior of the wild-type ileum into that of the M3 KO ileum. | |||||||||||||||
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However, M2 antibodies were only stimulated when M2 was in combination with NP, suggesting possible immune synergy of the two gene products. | |||||||||||||||
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PPARs and M2 activation of macrophages | |||||||||||||||
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The expression of the nuclear peroxisome proliferator-activated receptors (PPARs) is regulated by M1- or M2-inducing stimuli, and these receptors are generally considered to counteract inflammatory M1 macrophages, while actively promoting M2 activation. | |||||||||||||||
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ligands could be a valuable means of inducing M2 markers in vivo and altering macrophage functions [85]. | |||||||||||||||
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PPARs not only antagonize M1 activation, but actually support M2 activation. | |||||||||||||||
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In guinea pigs, ozone and allergen-induced M2 dysfunction is mediated by eosinophils that are recruited to airway nerves, and secrete major basic protein, that acts as an allosteric muscarinic M2 receptor antagonist [55]. | |||||||||||||||
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