INT14842

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Context Info
Confidence 0.57
First Reported 1989
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 7
Disease Relevance 0.67
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (EDN1) extracellular region (EDN1) cell-cell signaling (EDN1)
cytoplasm (EDN1)
Anatomy Link Frequency
coronary artery 4
vasculature 2
EDN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 16 99.52 Very High Very High Very High
lidocaine 1 98.48 Very High Very High Very High
Neuropeptide 2 85.60 High High
substance P 1 84.32 Quite High
bradykinin 1 82.80 Quite High
Angina 4 81.36 Quite High
Enkephalin 1 81.20 Quite High
local anesthetic 1 81.20 Quite High
Calcitonin gene-related peptide 3 80.44 Quite High
Dynorphin 1 80.08 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 5 100.00 Very High Very High Very High
Pallor 2 93.36 High High
Wheal 1 75.16 Quite High
Disease 1 44.92 Quite Low
Coronary Artery Disease 4 5.00 Very Low Very Low Very Low
Atherosclerosis 4 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 4 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The binding of 125I-endothelin was half-maximally inhibited by cold endothelin at a concentration (IC50) of 140 pM.
Negative_regulation (inhibited) of endothelin Binding (binding) of
1) Confidence 0.57 Published 1989 Journal Life Sci. Section Abstract Doc Link 2542708 Disease Relevance 0 Pain Relevance 0.35
Unlabeled bosentan prevented [125I]ET-1 binding to this vessel in a concentration-dependent manner, and functional studies indicated that bosentan antagonizes ET-1--induced constriction.
Negative_regulation (prevented) of ET-1 Binding (binding) of
2) Confidence 0.43 Published 1995 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 8587420 Disease Relevance 0 Pain Relevance 0.17
The H1 antagonist terfenadine (120 mg po) significantly reduced the flare area associated with endothelin 1: flare 5 min after intradermal endothelin (10 pmol, placebo treated), 668 +/- 405 mm2; terfenadine treated, 201 +/- 257 mm2 (P less than 0.05).
Negative_regulation (reduced) of endothelin Binding (associated) of associated with antagonist
3) Confidence 0.43 Published 1991 Journal J. Appl. Physiol. Section Abstract Doc Link 1707048 Disease Relevance 0.23 Pain Relevance 0.29
These data show that bosentan is able to reduce ET-1 binding to the human coronary artery and ET-1 constrictor effects in vitro.
Negative_regulation (reduce) of ET-1 Binding (binding) of in coronary artery
4) Confidence 0.43 Published 1995 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 8587420 Disease Relevance 0 Pain Relevance 0.20
These data show that bosentan is able to reduce ET-1 binding to the human coronary artery and ET-1 constrictor effects in vitro.
Negative_regulation (reduce) of ET-1 Binding (binding) of in coronary artery
5) Confidence 0.38 Published 1995 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 8587420 Disease Relevance 0 Pain Relevance 0.21
Competition studies were performed to determine the ability of bosentan to prevent [125I]ET-1 binding to the coronary vasculature.
Negative_regulation (prevent) of ET-1 Binding (binding) of in vasculature
6) Confidence 0.38 Published 1995 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 8587420 Disease Relevance 0 Pain Relevance 0.07
Endothelin-1- and endothelin-3-induced vasodilation in the surrounding area were also inhibited by both endothelin antagonists or by lidocaine.
Negative_regulation (inhibited) of Endothelin-1 Binding (vasodilation) of associated with antagonist, increased venous pressure under development and lidocaine
7) Confidence 0.37 Published 1994 Journal Hypertension Section Abstract Doc Link 8175165 Disease Relevance 0.43 Pain Relevance 0.37

General Comments

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